Month: January 2022

Category: Benzisoxazole. Authors Duan, SG; Hong, K; Tang, M; Tang, J; Liu, LX; Gao, GF; Shen, ZJ; Zhang, XM; Yi, Y in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Duan, Sheng-Guang; Hong, Kun; Tang, Ming; Tang, Jing; Liu, Lun-Xian; Zhang, Xi-Min; Yi, Yin] Guizhou Normal Univ, Sch Life Sci, Key Lab Natl Forestry & Grassland Adm Biodivers C, Key Lab Plant Physiol & Dev Regulat, Guiyang 550001, Guizhou, Peoples R China; [Gao, Gui-Feng] Chinese Acad Sci, Inst Soil Sci, State Key Lab Soil & Sustainable Agr, Nanjing 210008, Peoples R China; [Shen, Zhi-Jun] Xiamen Univ, Coll Environm & Ecol, Key Lab Subtrop Wetland Ecosyst Res, Minist Educ, Xiamen 361005, Fujian, Peoples R China in 2021, Cited 56. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7

Petal blight caused by fungi is among the most destructive diseases of Rhododendron, especially Rhododendron agastum. Nonetheless, the metabolite changes that occur during petal blight are unknown. We used untargeted gas chromatography time-of-flight mass spectrometry (GC-TOF-MS) and ultra-high performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UHPLC-QTOF-MS/MS) to compare the metabolite profiles of healthy and petal blight R. agastum flowers. Using GC-TOF-MS, 571 peaks were extracted, of which 189 metabolites were tentatively identified. On the other hand, 364 and 277 metabolites were tentatively identified in the positive and negative ionization modes of the UHPLC-QTOF-MS/MS, respectively. Principal component analysis (PCA) and orthogonal projections to latent structures-discriminant analysis (OPLS-DA) were able to clearly discriminate between healthy and petal blight flowers. Differentially abundant metabolites were primarily enriched in the biosynthesis of specialized metabolites. 17 accumulated specialized metabolites in petal blight flowers have been reported to have antifungal activity, and literature indicates that 9 of them are unique to plants. 3 metabolites (chlorogenic acid, medicarpin, and apigenin) are reportedly involved in resistance to blight caused by pathogens. We therefore speculate that the accumulation of chlorogenic acid, medicarpin, and apigenin may be involved in the resistance to petal blight. Our results suggest that these metabolites may be used as candidate biocontrol agents for the control fungal petal blight in Rhododendron.

Category: Benzisoxazole. About 2-Phenylbutanoic acid, If you have any questions, you can contact Duan, SG; Hong, K; Tang, M; Tang, J; Liu, LX; Gao, GF; Shen, ZJ; Zhang, XM; Yi, Y or concate me.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Application In Synthesis of 2-Phenylbutanoic acid. I found the field of Biotechnology & Applied Microbiology very interesting. Saw the article Synthesis and Biological Evaluation of New Benzylidenethiazolidine-2,4-dione Derivatives as 15-hydroxyprostaglandin Dehydrogenase Inhibitors to Control the Intracellular Levels of Prostaglandin E-2 for Wound Healing published in 2019, Reprint Addresses Cho, H (corresponding author), Chosun Univ, Dept Polymer Sci & Engn, Gwangju 501759, South Korea.; Choi, D (corresponding author), BK Co Ltd, Biotechnol Lab, Jeonbuk 5703, South Korea.. The CAS is 90-27-7. Through research, I have a further understanding and discovery of 2-Phenylbutanoic acid.

A novel series of benzylidenethiazolidine-2,4-dione derivatives was synthesized and investigated for 15-hydroxyprostaglandin dehydrogenase (15-PGDH)-scavenging activity, PGE(2) release, and wound-healing activity. Among the tested derivatives, seven compounds (3, 9, 11, 12, 13, 14, and 25) resulted in a 50% inhibition of 15-PGDH at concentrations between 0.07 and 0.2 mu M and increased PGE(2) levels from 300 to over 600% in A549 cells treated with 5.0 and 10.0 mu M of the compounds for 12 h. A scratch wound-healing assay using HaCaT cell line was conducted to verify the effects of 10 mu M of these compounds on cell regeneration. The closure rate of the scratch wound healing showed that all compounds (3, 9, 11, 12, 13, 14, and 25) had greater wound regeneration effects than the cell growth factor, TGF-beta 1, which was used as the positive control. In particular, (Z)-N-benzyl-4-((2,4-dioxothiazolidin-5-ylidene)methyl)benzamide (compound 14) showed that the highest wound closure rate, which was 360%; this is about 3.6-fold higher than that of TGF-beta 1. Overall, these results show that compound 14 may be considered a promising candidate for the development of novel wound-healing agents.

Application In Synthesis of 2-Phenylbutanoic acid. About 2-Phenylbutanoic acid, If you have any questions, you can contact Yu, I; Choi, D; Lee, HK; Cho, H or concate me.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

In 2021 APPL MICROBIOL BIOT published article about CONTAMINATED SOIL; ENVIRONMENTAL-POLLUTANTS; RING-CLEAVAGE; BIODEGRADATION; BIOREMEDIATION; DEGRADATION; OXIDATION; HYDROCARBONS; BACTERIA; FUNGI in [Mikolasch, Annett; Reinhard, Anne; Zuehlke, Daniele; Riedel, Katharina; Urich, Tim; Schauer, Frieder] Ernst Moritz Arndt Univ Greifswald, Inst Microbiol, Felix Hausdorff Str 8, D-17489 Greifswald, Germany; [Berzhanova, Ramza; Omirbekova, Anel; Mukasheva, Togzhan] Al Farabi Kazakh Natl Univ, Dept Biol & Biotechnol, Al Farabi Ave 71, Alma Ata 050040, Kazakhstan; [Meister, Mareike] Leibniz Inst Plasma Sci & Technol INP, Felix Hausdorff Str 2, D-17489 Greifswald, Germany in 2021, Cited 60. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7. Category: Benzisoxazole

The yeast strain Moniliella spathulata SBUG-Y 2180 was isolated from oil-contaminated soil at the Tengiz oil field in the Atyrau region of Kazakhstan on the basis of its unique ability to use crude oil and its components as the sole carbon and energy source. This yeast used a large number of hydrocarbons as substrates (more than 150), including n-alkanes with chain lengths ranging from C-10 to C-32, monomethyl- and monoethyl-substituted alkanes (C-9-C-23), and n-alkylcyclo alkanes with alkyl chain lengths from 3 to 24 carbon atoms as well as substituted monoaromatic and diaromatic hydrocarbons. Metabolism of this huge range of hydrocarbon substrates produced a very large number of aliphatic, alicyclic, and aromatic acids. Fifty-one of these were identified by GC/MS analyses. This is the first report of the degradation and formation of such a large number of compounds by a yeast. Inoculation of barley seeds with M. spathulata SBUG-Y 2180 had a positive effect on shoot and root development of plants grown in oil-contaminated sand, pointing toward potential applications of the yeast in bioremediation of polluted soils.

Welcome to talk about 90-27-7, If you have any questions, you can contact Mikolasch, A; Berzhanova, R; Omirbekova, A; Reinhard, A; Zuhlke, D; Meister, M; Mukasheva, T; Riedel, K; Urich, T; Schauer, F or send Email.. Category: Benzisoxazole

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

In 2019 ANGEW CHEM INT EDIT published article about PRACTICAL CHIRAL AUXILIARY; ENANTIOSELECTIVE PROTONATION; BRONSTED ACID; DISILYL ACETALS; ENOL ETHERS; ALKYLATION; PSEUDOEPHEDRINE; GENERATION; ALDEHYDES in [Mandrelli, Francesca; Blond, Aurelie; James, Thomas; Kim, Hyejin; List, Benjamin] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany in 2019, Cited 52. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7. Recommanded Product: 2-Phenylbutanoic acid

We report a highly enantioselective catalytic protonation of bis-silyl ketene acetals. Our method delivers alpha-branched carboxylic acids, including nonsteroidal anti-inflammatory arylpropionic acids such as Ibuprofen, in high enantiomeric purity and high yields. The process can be incorporated in an overall deracemization of alpha-branched carboxylic acids, involving a double deprotonation and silylation followed by the catalytic asymmetric protonation.

Welcome to talk about 90-27-7, If you have any questions, you can contact Mandrelli, F; Blond, A; James, T; Kim, H; List, B or send Email.. Recommanded Product: 2-Phenylbutanoic acid

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Dong, L; Tang, S; Deng, FC; Gong, YF; Zhao, KF; Zhou, JJ; Liang, DH; Fang, JL; Hecker, M; Giesy, JP; Bai, XT; Zhang, HW in [Dong, Li; Tang, Song; Deng, Fuchang; Zhao, Kangfeng; Fang, Jianlong; Bai, Xuetao; Zhang, Hongwei] Chinese Ctr Dis Control & Prevent, Natl Inst Environm Hlth, Beijing 100021, Peoples R China; [Tang, Song] Nanjing Med Univ, Sch Publ Hlth, Ctr Global Hlth, Nanjing 211166, Jiangsu, Peoples R China; [Deng, Fuchang] Southwest Univ, Coll Biotechnol, Chongqing 400715, Peoples R China; [Gong, Yufeng; Hecker, Markus; Giesy, John P.] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada; [Zhou, Jianjun] Tongji Univ, Sch Med, East Hosp, Res Ctr Translat Med,Canc Stem Cell Inst, Shanghai 310000, Peoples R China; [Liang, Donghai] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA; [Hecker, Markus] Univ Saskatchewan, Sch Environm & Sustainabil, Saskatoon, SK S7N 5B3, Canada; [Giesy, John P.] Univ Saskatchewan, Dept Biomed & Vet Biosci, Saskatoon, SK S7N 5B4, Canada; [Giesy, John P.] Baylor Univ, Dept Environm Sci, Waco, TX 76798 USA published Shape-dependent toxicity of alumina nanoparticles in rat astrocytes in 2019, Cited 64. Computed Properties of C10H12O2. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7.

Nanosized alumina (Al2O3-NPs), a widely used nanoparticle in numerous commercial applications, is released into environment posing a threat to the health of wildlife and humans. Recent research has revealed essential roles of physicochemical properties of nanoparticles in determining their toxicity potencies. However, influence of shape on neurotoxicity induced by heterogeneous Al2O3 -NPs remains unknown. We herein compared the neurotoxicity of two shapes of gamma-Al2O3-NPs (flake versus rod) and their effects on metabolic profiles of astrocytes in rat cerebral cortex. While exposed to both shapes caused significant cytotoxicity and apoptosis in a dose-dependent manner after 72 h exposure, a significantly stronger response was observed for nanorods than for nanoflakes. These effects were associated with significantly greater ROS accumulation and inflammation induction, as indicated by increased concentrations of IL-1 beta, IL-2 and IL-6. Using untargeted metabolomics, significant alternations in metabolism of amino adds, lipids and purines, and pyrimidines were observed after exposure to both types. Moreover, changes in the metabolome caused by nanorods were significantly greater than those by nanoflakes as also indicated by physiological stress responses to ROS, inflammation, and apoptosis. Taken together, these findings demonstrated the critical role of morphology in determining toxic potencies of nanoalumina and its underlying mechanisms of toxic actions. (C) 2019 Elsevier B.V. All rights reserved.

Bye, fridends, I hope you can learn more about C10H12O2, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C10H12O2

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Ye, ZH; Wu, YQ; Chen, N; Zhang, H; Zhu, K; Ding, MR; Liu, M; Li, Y; Zhang, FZ in [Ye, Zenghui; Chen, Na; Zhang, Hong; Zhu, Kai; Ding, Mingruo; Liu, Min; Li, Yong; Zhang, Fengzhi] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China; [Ye, Zenghui; Zhu, Kai; Zhang, Fengzhi] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China published Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives in 2020, Cited 48. Safety of 2-Phenylbutanoic acid. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7.

Triazolopyridinone derivatives are of high value in both medicinal and material chemistry. However, the chiral or hindered triazolopyridinone derivatives remain an underexplored area of chemical space because they are difficult to prepare via conventional methods. Here we report an electrochemical rearrangement for the efficient synthesis of otherwise inaccessible triazolopyridinones with diverse alkyl carboxylic acids as starting materials. This enables the efficient preparation of more than 60 functionalized triazolopyridinones under mild conditions in a sustainable manner. This method is evaluated for the late stage modification of bioactive natural products, amino acids and pharmaceuticals, and it is further applied to the decagram scale preparation of enantiopure triazolopyridinones. The control experiments support a mechanism involving an oxidative cyclization and 1,2-carbon migration. This facile and scalable rearrangement demonstrates the power of electrochemical synthesis to access otherwise-inaccessible triazolopyridinones and may find wide application in organic, material and medicinal chemistry. Chiral and hindered triazolopyridinone derivatives are an underexplored area of chemical space mainly due to their challenging synthesis via classical methods. Here, the authors report an electrochemical rearrangement for the synthesis of triazolopyridinones using diverse, available alkyl carboxylic acids as starting materials.

Safety of 2-Phenylbutanoic acid. Bye, fridends, I hope you can learn more about C10H12O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Recently I am researching about ANALOGS; INHIBITORS, Saw an article supported by the Ataturk University, Faculty of Sciences, Department of Chemistry. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Atmaca, U. The CAS is 90-27-7. Through research, I have a further understanding and discovery of 2-Phenylbutanoic acid. Formula: C10H12O2

Effective synthesis of novel sulfamates from various carboxylic acids has been developed in the presence of chlorosulfonyl isocyanate (CSI) in mild conditions. Several acids, bases and solvents effects were investigated for one-pot synthesis sulfamates as a catalyst. Finally, triflic acid was found to possess efficiently under optimized conditions in acetonitrile. This method is easy, fair price and practical. It can be synthesized on grams and milligrams scale. (C) 2019 Elsevier Ltd. All rights reserved.

Formula: C10H12O2. Bye, fridends, I hope you can learn more about C10H12O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

HPLC of Formula: C10H12O2. I found the field of Environmental Sciences & Ecology very interesting. Saw the article Shape-dependent toxicity of alumina nanoparticles in rat astrocytes published in 2019, Reprint Addresses Tang, S; Bai, XT (corresponding author), 7 Panjiayuan Nanli, Beijing 100021, Peoples R China.. The CAS is 90-27-7. Through research, I have a further understanding and discovery of 2-Phenylbutanoic acid.

Nanosized alumina (Al2O3-NPs), a widely used nanoparticle in numerous commercial applications, is released into environment posing a threat to the health of wildlife and humans. Recent research has revealed essential roles of physicochemical properties of nanoparticles in determining their toxicity potencies. However, influence of shape on neurotoxicity induced by heterogeneous Al2O3 -NPs remains unknown. We herein compared the neurotoxicity of two shapes of gamma-Al2O3-NPs (flake versus rod) and their effects on metabolic profiles of astrocytes in rat cerebral cortex. While exposed to both shapes caused significant cytotoxicity and apoptosis in a dose-dependent manner after 72 h exposure, a significantly stronger response was observed for nanorods than for nanoflakes. These effects were associated with significantly greater ROS accumulation and inflammation induction, as indicated by increased concentrations of IL-1 beta, IL-2 and IL-6. Using untargeted metabolomics, significant alternations in metabolism of amino adds, lipids and purines, and pyrimidines were observed after exposure to both types. Moreover, changes in the metabolome caused by nanorods were significantly greater than those by nanoflakes as also indicated by physiological stress responses to ROS, inflammation, and apoptosis. Taken together, these findings demonstrated the critical role of morphology in determining toxic potencies of nanoalumina and its underlying mechanisms of toxic actions. (C) 2019 Elsevier B.V. All rights reserved.

Welcome to talk about 90-27-7, If you have any questions, you can contact Dong, L; Tang, S; Deng, FC; Gong, YF; Zhao, KF; Zhou, JJ; Liang, DH; Fang, JL; Hecker, M; Giesy, JP; Bai, XT; Zhang, HW or send Email.. HPLC of Formula: C10H12O2

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Cu-catalyzed oxygenation of alkene-tethered amides with O(2)via unactivated C & xe001;C bond cleavage: a direct approach to cyclic imides published in 2019. Recommanded Product: 2-Phenylbutanoic acid, Reprint Addresses Jiao, N (corresponding author), Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Xue Yuan Rd 38, Beijing 100191, Peoples R China.; Jiao, N (corresponding author), Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China.. The CAS is 90-27-7. Through research, I have a further understanding and discovery of 2-Phenylbutanoic acid

The transformations of unactivated alkenes through C & xe001;C bond double cleavage are always attractive but very challenging. We report herein a chemoselective approach to valuable cyclic imides by a novel Cu-catalyzed geminal amino-oxygenation of unactivated C & xe001;C bonds. O-2 was successfully employed as the oxidant as well as the O-source and was incorporated into alkenyl amides via C & xe001;C bond cleavage for the efficient preparation of succinimide or glutarimide derivatives. Moreover, the present strategy under simple conditions can be used in the late-stage modification of biologically active compounds and the synthesis of pharmaceuticals, which demonstrated the potential application.

Recommanded Product: 2-Phenylbutanoic acid. About 2-Phenylbutanoic acid, If you have any questions, you can contact Li, JH; Wei, JL; Zhu, BC; Wang, T; Jiao, N or concate me.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Name: 2-Phenylbutanoic acid. Authors Du, RL; Bei, HK; Jia, LH; Huang, CY; Chen, QZ; Tao, CL; Chen, J; Bo, HB in ELSEVIER IRELAND LTD published article about in [Du, Ruilan; Bei, Haikang; Jia, Lihong; Huang, Chunyan; Chen, Qizhu; Tao, Changli; Bo, Huaben] Guangdong Pharmaceut Univ, Sch Biosci & Biopharmaceut, Guangdong Prov Key Lab Biotechnol Drug Candidates, Guangzhou 510006, Guangdong, Peoples R China; [Chen, Jun] Guangdong Pharmaceut Univ, Coll Pharm, Guangzhou 510006, Guangdong, Peoples R China in 2020, Cited 32. The Name is 2-Phenylbutanoic acid. Through research, I have a further understanding and discovery of 90-27-7

Ethnopharmacological relevance: Danggui Buxue Tang (DBT) has been used to promote hematopoiesis and relieve myelosuppression in China. Antibiotics can cause myelosuppression through gut microbiota disorders. Aim of the study: This study aims to explore the way of DBT to alleviate the metabolic disorder caused by antibiotics. Materials and methods: In this study, 16S rRNA sequencing was used to detect the change of gut microbiota, metabolomics to analyze the change of metabolites. Correlation analysis was used to establishment the correlation between gut microbiota and metabolites. PICRUST 2 was used to predict the function of gut microbiota. Results: Results showed that eighty-two genera of gut microbiota were affected by antibiotic, while twelve were significantly restored after DBT. Seventy-four potential metabolites were significantly different from the antibiotics and DBT. We found significant recovery by the Bacteroides and Rikenellaceae RC9 after DBT. The metabolic pathways influenced by the antibiotic treatment included primary and secondary bile biosynthesis, etc. The metabolic pathways that could be restored after DBT included the primary and secondary bile acid biosynthesis pathway, etc. Through correlation analysis, we found a correlation between the Bacteroides, Rikenellaceae_RC9_gut_groupand other potential differential metabolisms such as those of taurodeoxycholic acid, N-phenylacetyl glycine, etc. The functional prediction showed that the biosynthesis of primary bile acid, secondary bile acid was significantly affected. Conclusions: DBT can restore the gut and reverse the metabolic disorder caused by antibiotics through Bacteroides, and it provides a new medical idea regarding the gut microbiota balance.

Welcome to talk about 90-27-7, If you have any questions, you can contact Du, RL; Bei, HK; Jia, LH; Huang, CY; Chen, QZ; Tao, CL; Chen, J; Bo, HB or send Email.. Name: 2-Phenylbutanoic acid

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics