Day: October 12, 2022

Ling, Fei; Liu, Tao; Xu, Chao; He, Jiaying; Zhang, Wangqin; Ling, Changwu; Liu, Lei; Zhong, Weihui published the artcile< Divergent electrolysis for the controllable coupling of thiols with 1,2-dichloroethane: a mild approach to sulfide and sulfoxide>, Product Details of C12H13FN2O, the main research area is chloroethyl sulfide green preparation; thiol dichloroethane electrochem sulfidation; sulfoxide chloroethyl green preparation; dichloroethane thiol electrochem sulfoxidation.

A safe, practical and eco-friendly electrochem. methodol. was reported for the controllable dechloro-coupling of 1,2-dichloroethane (DCE) with thiols, providing value-added β-chloroethyl-sulfides ArSCH2CH2Cl [Ar = Ph, 4-MeC6H4, 2-naphthyl, etc.] and β-chloroethyl-sulfoxides Ar1S(O)CH2CH2Cl [Ar1 = Ph, 2-BrC6H4, 2,4-di-MeC6H3, etc.], which served as versatile building blocks in the efficient late-stage conversion to bioactive mols. The mildness and practicality of this protocol was further demonstrated by the total synthesis of anti-gout drug sulfinpyrazone in a 32% total yield over three steps.

Green Chemistry published new progress about Electrochemical reaction. 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Product Details of C12H13FN2O.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Sivala, Munichandra Reddy; Chintha, Venkataramaiah; Potla, Krishna Murthy; Chinnam, Sampath; Chamarthi, Naga Raju published the artcile< In silico docking studies and synthesis of new phosphoramidate derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole as potential antimicrobial agents>, Safety of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole, the main research area is phosphoramidate docking studies antimicrobial agents; Phosphoramidates; anti-bacterial activity; anti-fungal activity; benzisoxazole; molecular docking.

A new class of phosphoramidate derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole were synthesized in good to excellent yields (78-96%) by an in situ, three-step process. All the synthesized mols. were evaluated for anti-bacterial and anti-fungal activities using in vitro and in silico methods. The results revealed that the compounds , , , , and exhibited the most promising anti-bacterial activity against S. aureus, B. subtilis, K. pneumoniae, S. typhi and P. mirabilis and anti-fungal activity against A. niger and A. flavus when compared with the standard drugs Norfloxacin and Nystatin at concentrations of 25, 50, 75 and 100μg/mL. The rest of the title compounds have shown moderate activity against all the bacterial and fungal strains. Mol. docking studies revealed that the synthesized compounds have exhibited significant binding modes with high dock scores ranging from -7.2 to -9.5 against 3V2B protein when compared with the standard drugs Norfloxacin (-5.8) and Nystatin (-6.6) resp. Hence, it is suggested that the synthesized phosphoramidate derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole will stand as the promising antimicrobial drug candidates in future.

Journal of Receptors and Signal Transduction published new progress about Antimicrobial agents. 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Safety of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Zhang, Ze-Xin; Willis, Michael C. published the artcile< Sulfondiimidamides as new functional groups for synthetic and medicinal chemistry>, Formula: C12H13FN2O, the main research area is sulfondiimidamide preparation.

Due to their three-dimensional structure, chem. and metabolic stability, polarity, and hydrogen-bonding ability, sulfonamides RS(=NC(CH3)2CH2(CH3)3)(=NNs)R1 (R1 = Et, 4-fluorophenyl, cyclopropyl, pyridin-3-yl, etc. ;NH2, 2-methylpropan-2-aminyl, morpholin-4-yl) occupy a privileged position among the functional groups used to design bioactive mols. The mono aza variants, sulfonimidamides, a functional group known since the 1930s, possess an extra nitrogen atom, which delivers an addnl. point of diversity and introduces chirality at sulfur. The sulfondiimidamides are viable mols. and by using an unsym. sulfurdiimide as a linchpin, in combination with organometallic reagents RMgX (X = Br, Cl) and amines R1NH, their three-component assembly is showed. Variation of the substrates, and the controlled manipulation of nitrogen functionality, allows a broad range of substituents to be introduced at all three nitrogen atoms and at carbon.

Chem published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Formula: C12H13FN2O.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Li, Meng; Wang, Dong-Hui published the artcile< Copper-Catalyzed 3-Positional Amination of 2-Azulenols with O-Benzoylhydroxylamines>, Product Details of C12H13FN2O, the main research area is azulenol benzoylhydroxylamine copper catalyst regioselective amination; aminoazulenol preparation.

A copper-catalyzed ortho-selective amination of 2-azulenols with O-benzoylhydroxylamines (RR’N-OBz) to synthesize ortho-aminoazulenols was reported. A wide range of functional groups on amines were compatible, furnishing the corresponding amino-azulene derivatives in moderate to good yields. The further synthetic elaboration using 3-amino-2-azulenols as starting materials was demonstrated.

Organic Letters published new progress about Amination catalysts (regioselective). 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Product Details of C12H13FN2O.

Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics