So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nguyen, D. Thao; Lenstra, Danny C.; Mecinovic, Jasmin researched the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8 ).Name: Methyl tetrahydrofuran-2-carboxylate.They published the article 《Chemoselective calcium-catalyzed direct amidation of carboxylic esters》 about this compound( cas:37443-42-8 ) in RSC Advances. Keywords: amide green preparation chemoselective; carboxylic ester primary amine calcium catalyst amide bond formation. We’ll tell you more about this compound (cas:37443-42-8).
Unactivated carboxylic esters and primary amines undergo calcium-catalyzed direct amide bond formation to afford amides I [R1 = n-Pr, Ph, 4-hydroxybutyl, etc.; R2 = 2-thienyl, Ph, Bn, etc.] in excellent yields under homogeneous conditions in toluene. This green and mild reaction proceeds chemoselectively with esters, whereas related carboxylic acids and amides remain unreactive.
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics