Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Chirality called The enzymatic resolution of 1-(4-chlorophenyl)ethylamine by Novozym 435 to prepare a novel triazolopyrimidine herbicide, Author is Zhang, Yinjun; Cheng, Feifei; Yan, Hongde; Zheng, Jianyong; Wang, Zhao, which mentions a compound: 37443-42-8, SMILESS is O=C(C1OCCC1)OC, Molecular C6H10O3, Recommanded Product: Methyl tetrahydrofuran-2-carboxylate.
The kinetic resolution of (R,S)-1-(4-chlorophenyl)ethylamine was accomplished using a com. lipase from Candida antarctica (Novozym 435). The performance of this lipase was investigated for the enantioselective amidation of (R,S)-1-(4-chlorophenyl)ethylamine, leaving the target product (S)-1-(4-chlorophenyl)ethylamine in its unreacted form. The effects of various types of solvents and an acyl donor, the molar ratio of the substrate to the acyl donor, and the reaction temperature were studied. The optimum reaction conditions were found to result in amidation with Me 2-tetrahydrofuroate at 40°C in Me tert-Bu ether, with a substrate/acyl donor molar ratio of 1:2.4. The conversion rate of (R,S)-1-(4-chlorophenyl)ethylamine was 52%, with an enantiomeric excess of 99% towards the unreacted substrate in a reaction time of 22 h. Finally, using optically pure (S)-1-(4-chlorophenyl)ethylamine as the raw material, the chem. synthesis of (S)-N-(1-(4-chlorphenyl)ethyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)acetamide, a novel triazolopyrimidine herbicide, was achieved, and the total yield and purity were 83.5% and 95.3%, resp.
In addition to the literature in the link below, there is a lot of literature about this compound(Methyl tetrahydrofuran-2-carboxylate)Recommanded Product: Methyl tetrahydrofuran-2-carboxylate, illustrating the importance and wide applicability of this compound(37443-42-8).
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics