Porcs-Makkay, Marta; Gyujto, Imre; Lukacs, Gyula; Komaromi, Anna; Toth, Gabor; Garadi, Zsofia; Simig, Gyula; Volk, Balazs published the artcile< Synthesis, Alkylation and Reduction of 4-Aryl-2H-1,2,3-benzothiadiazine 1,1-dioxides>, Related Products of 84163-77-9, the main research area is aryl benzothiadiazine dioxide preparation alkylation hydrogenation allosteric modulator activity; aromatic chlorosulfonyl ketal heterocyclization.
The compound ortho-(2-Aryl-1,3-dioxolan-2-yl)benzenesulfonyl chlorides I (R = Ph, 3-ClC6H4, 3-ClC6H4, etc.; X = H, Cl, OMe; Y = H, Cl) obtained from benzophenone ketals II by directed ortho-lithiation chem. were cyclized either with hydrazine monohydrate or with acetohydrazide to furnish variously substituted 4-aryl-2H-1,2,3-benzothiadiazine 1,1-dioxides III. Alkylation of benzothiadiazine dioxides with alkyl iodides R1I (R1 = Me, Et, n-butyl) under basic conditions was elaborated, revealing significant differences compared to the reactivity of 4-unsubstituted ones IV. Hydrogenation of the C=N double bond in the presence of platinum(IV) oxide is also described. Detailed NMR studies and DFT calculations supported the structure elucidation of the compds IV (X = Cl; Y = Cl; R = Ph; R1 = Me) and 7,8-dichloro-3-methyl-1-oxo-4-phenyl-2H-1,2,3-benzothiadiazin-3-ium-1-olate.
ChemistrySelect published new progress about Alkylation. 84163-77-9 belongs to class benzisoxazole, and the molecular formula is C12H13FN2O, Related Products of 84163-77-9.
Referemce:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics