Category: benzisoxazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis, in silico, and in vitro evaluation of anti-leishmanial activity of oxadiazoles and indolizine containing compounds flagged against anti-targets.
Due to the lack of approved vaccines against human leishmaniasis and the limitations of the current chemotherapy inducing side effects and drug resistance, development of new, effective chemotherapeutic agents is essential. This study describes the synthesis of a series of novel oxadiazoles and indolizine-containing compounds The compounds were screened in silico using an EIIP/AQVN filter followed by ligand-based virtual screening and mol. docking to parasite arginase. Top hits were further screened vs. human arginase and finally against an anti-target battery to tag their possible interactions with proteins essential for the metabolism and clearance of many substances. Eight candidate compounds were selected for further exptl. testing. The results show measurable in vitro anti-leishmanial activity for three compounds One compound with an IC50 value of 2.18 μM on Leishmania donovani intramacrophage amastigotes is clearly better positioned than the others as an interesting mol. template for further development of new anti-leishmanial agents.
Here is just a brief introduction to this compound(3326-71-4)Category: benzisoxazole, more information about the compound(2-Furoic hydrazide) is in the article, you can click the link below.
Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics