Electric Literature of C5H6N2O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Ruthenium-Catalyzed Three-Component Alkylation: A Tandem Approach to the Synthesis of Nonsymmetric N,N-Dialkyl Acyl Hydrazides with Alcohols. Author is Bettoni, Leo; Joly, Nicolas; Lohier, Jean-Francois; Gaillard, Sylvain; Poater, Albert; Renaud, Jean-Luc.
The borrowing hydrogen strategy has been applied in the synthesis of nonsym. N,N-dialkylated acyl hydrazides via a tandem three-component reaction catalyzed by a phosphine free diaminocyclopentadienone ruthenium tricarbonyl complex. This strategy represents the first direct one-pot approach to nonsym. functionalized acyl hydrazides. Different aromatic acyl hydrazides underwent dialkylation with a variety of primary or secondary alcs. and methanol or ethanol as alkylating agents in mild reaction conditions and good yields. Deuterium labeling experiments suggested that the primary or secondary alc. was the hydrogen source in this tandem process. DFT calculations show that the combination of the tandem mixed product cannot be perfectly explained neither structurally nor electronically, but might be dependent of the phys. state of the aldehyde or ketone intermediate (gaz vs. liquid) at the reaction temperature
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics