The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8 ) is researched.Quality Control of Methyl tetrahydrofuran-2-carboxylate.Kong, Xiao-Lin; Yang, Li-Ping; Xu, Tian-Ming published the article 《Synthesis of N-(2-tetrahydrofuroyl)piperazine》 about this compound( cas:37443-42-8 ) in Zhongguo Yiyao Gongye Zazhi. Keywords: hydrofuroylpiperazine preparation. Let’s learn more about this compound (cas:37443-42-8).
Title compound I (R = 1-piperazyl) was prepared with 61% yield from condensation of I (R = OCH3), prepared from H2/Ni reduction of 2-methoxycarbonylfuran, with piperazine·6H2O in the presence of NH4Br under reflux for 6 h.
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics