Category: 3326-71-4

COA of Formula: C5H6N2O2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about A “”Turn-On”” Fluorescence Probe for Selective Detection of Al3+ in Aqueous Environment: Crystal Structure, Theoretical and Cell Imaging Studies. Author is Rani Gupta, Shraddha; Yadav, Pranjalee; Singh, Priya; Koch, Biplob; Singh, Vinod P..

A furan-based water soluble fluorescent probe (E)-N′-(2,4-dihydroxybenzylidene)furan-2-carbohydrazide (DBF) has been synthesized and characterized by 1H NMR, 13C NMR, ESI-mass spectroscopy and single crystal X-ray diffraction techniques. The synthesized probe exhibits a “”turn-on”” fluorescence response towards Al3+ in Tris-HCl buffer (10 mM) with no significant interference from other metal ions. The strong fluorescence in the presence of Al3+ is attributed to the CHEF (chelation enhanced fluorescence), inhibition of PET (photo-induced electron transfer) and C=N isomerization. 1 : 1 stoichiometric ratio between DBF and Al3+ was rationalized by Job′s plot. Binding constant and LOD were calculated to be 1.031×105 M-1 and 6.34×10-8 M, resp. MTT assay on live A549 cells indicated no serious cytotoxicity in the cells even at higher concentration Further, DBF was successfully used for the detection of accumulated Al3+ in the cytoplasm of cells.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Yarmohammadi, Elahe; Beyzaei, Hamid; Aryan, Reza; Moradi, Ashraf published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).Application of 3326-71-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

In this study, a novel process for the synthesis of 5-substituted 1,3,4-oxadiazole-2-thiol derivatives I (R = Ph, 4-pyridinyl, 4-methyl-1,2,3-thiadiazol-5yl, etc.) was proposed via ultrasound-assisted reaction of aryl hydrazides RC(O)NHNH2 with CS2 (1:1 molar ratio) in some drops of DMF in the absence of basic or acidic catalysts. They were produced in good to excellent yields under easy workup and purification conditions. In order to prove the usefulness of the prepared compounds, their antioxidant, antibacterial, and antifungal potentials were screened by DPPH free radical scavenging, serial twofold microdilution and streak plate methods. Acceptable to significant inhibitory activities were observed with synthesized heterocycles. The results showed that compound I (R = 4-fluorophenyl) is a broad-spectrum antimicrobial agent. Many of them displayed remarkable antioxidant properties comparable to standard controls (ascorbic acid and α-tocopherol). Synthesized 1,3,4-oxadiazoles I are also potent candidates to treat cancer, Parkinson, inflammatory, and diabetes diseases.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Mehmood, Mehwish; Imtiaz-ud-Din; Nawaz Tahir, Muhammad; Haq, Ihsan-ul; Zahra, Syeda Saniya published the article 《Synthetic stratagem, characterization and biocidal applications of triorganotin(IV) complexes derived from hydrazide/hydrazone analogues》. Keywords: triorganotin benzylidene benzohydrazide preparation antibacterial antifungal antidiabetic activity; alpha amylase inhibitor triorganotin benzylidene benzohydrazide complex; furanylmethylene furancarbohydrazide preparation crystal mol structure.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Quality Control of 2-Furoic hydrazide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.

A series of Schiff base ligands as benzylidene benzohydrazide and their hydrazone analogs (Ia-Ic) have been synthesized and then complexed with organotin(IV) moiety having general formula [R’3SnL] to get the target compounds (1-9), where L = C4H3OCONHN:CHR, R = C6H5O (Ia), C4H5O (Ib), C6H3Cl2 (Ic) and R’ = -CH3 (1-3), -CH2Ph (4-6), -Ph (7-9). They were fully characterized using FT-IR, NMR (1H, 13C and 119Sn) spectroscopy, along with elemental anal. and m.p. One of the precursor (Ib) has been analyzed by single crystal XRD to further authenticate the structure. The 119Sn NMR data suggest the mol. geometry of organotin derivatives as distorted pentagonal bipyramidal. They were also evaluated for their antibacterial, antifungal, α-amylase inhibition, DPPH, total reducing power and total antioxidant activities. Triaryltin(IV) derivatives show good antibacterial and antifungal activity. Whereas the data for antidiabetic activity demonstrated that the compounds may serve as moderately effective alpha amylase inhibitor.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Ruthenium-Catalyzed Three-Component Alkylation: A Tandem Approach to the Synthesis of Nonsymmetric N,N-Dialkyl Acyl Hydrazides with Alcohols.Quality Control of 2-Furoic hydrazide.

The borrowing hydrogen strategy has been applied in the synthesis of nonsym. N,N-dialkylated acyl hydrazides via a tandem three-component reaction catalyzed by a phosphine free diaminocyclopentadienone ruthenium tricarbonyl complex. This strategy represents the first direct one-pot approach to nonsym. functionalized acyl hydrazides. Different aromatic acyl hydrazides underwent dialkylation with a variety of primary or secondary alcs. and methanol or ethanol as alkylating agents in mild reaction conditions and good yields. Deuterium labeling experiments suggested that the primary or secondary alc. was the hydrogen source in this tandem process. DFT calculations show that the combination of the tandem mixed product cannot be perfectly explained neither structurally nor electronically, but might be dependent of the phys. state of the aldehyde or ketone intermediate (gaz vs. liquid) at the reaction temperature

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Name: 2-Furoic hydrazide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about A simple fluorescent probe for selective detection of Al3+ based on furan Schiff base and its crystal structure. Author is Peng, Hua-nan; Liu, Yi-qing; Huang, Jia-qi; Huang, Shou-Shun; Cai, Xin-ping; Xu, Shu-juan; Huang, Ai; Zeng, Qiang; Xu, Miao.

A simple “”turn-on”” fluorescent probe L was synthesized by condensation of furan-2-carbohydrazide and 2-hydroxy-4-methoxybenzaldehyde, and its structure was confirmed by single crystal X-ray diffraction. The probe L exhibited excellent selectivity towards Al3+ over other coexistent metal ions with remarkable fluorescence enhancement, accompanied by color change from colorless to blue. Moreover, the probe L showed high sensitivity to Al3+ with low detection limit (3.10 x 10-8 M) in the pH range of 3.0-8.0. The possible sensing mechanisms of L toward Al3+ were determined by Job plots experiments, high resolution mass spectrometry (HRMS), 1H NMR spectra and the d. functional theory (DFT) calculations Addnl., the probe L was successfully applied for detection of Al3+ in water samples with satisfactory results.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Qian, Peng; Zhou, Zhenghong; Wang, Li; Wang, Zhicheng; Wang, Zhongwei; Zhang, Zhenlei; Sheng, Liangquan published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).HPLC of Formula: 3326-71-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

An intramol. decarboxylative coupling reaction for the construction of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives was developed from readily available isatins and hydrazides by virtue of electrochem. In this reaction, isatins were employed as amino-attached C1 sources, providing a variety of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives with moderate to good yields.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Russian Journal of General Chemistry called Photoconductivity, Antioxidant, and Antimicrobial Activities of Some Acenaphthenequinone Derivatives, Author is Mhaidat, I.; Taha, Z. A.; Al Momani, W.; Hijazi, A. K., which mentions a compound: 3326-71-4, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2, SDS of cas: 3326-71-4.

Photoconductive acenaphthenequinone derivatives I (R = thiophen-2-yl, 3-hydroxynaphthalen-2-yl, pyridin-4-yl, etc.) have been synthesized by a one-pot process of acenaphthenequinone with different aromatic hydrazides RC(O)NHNH2. Photoelectrochem. (PEC) measurements reveal that the compounds demonstrate photoresponse upon illumination by light of intensities 1000 and 10000 W/m2. The photoconductivity behavior of the derivatives I is enhanced in the presence of electron donor groups attached to the aromatic ring. Thereby, these products may be used in material devices as organic thin film transistors, on/off sensors, etc. The antioxidant activity of the products has been tested by DPPH radical scavenging method in vitro, indicating their significant potential. Antimicrobial activity of the derivatives I has been estimated by min. inhibitory concentration (MIC, mg/mL) using the micro-broth dilution method. The compounds are moderately active against some Gram pos. bacteria and Candida albicans and completely inactive against Gram neg. bacteria tested.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Facile synthesis, characterization, nucleic acid interaction and photoluminescent properties of (E)-furan-2-yl(2-(2-hydroxybenzylidene)hydrazinyl) methaniminium and its Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes, published in 2019-02-15, which mentions a compound: 3326-71-4, Name is 2-Furoic hydrazide, Molecular C5H6N2O2, Formula: C5H6N2O2.

The present work describes the synthesis of novel (E)-furan-2-yl(2-(2-hydroxybenzylidene)hydrazinyl) methaniminium in water/methanol(3:1) mixture, water acting as catalyst and also solvent to expedite reaction rate with high yield. In which, amine exchange and condensation reaction takes place between N-salicylidene aniline and furanoic acid hydrazide at one step. The structural characterization of prepared ligand was carried out by single crystal x-ray diffraction, elemental anal. and spectroscopy (UV-visible, FTIR and NMR) techniques. The single crystal x-ray diffraction result indicates that the ligand crystallizes in orthorhombic system with Pca21 space group. Further, Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes of ligand were prepared Complexes were analyzed by elemental anal., magnetic susceptibility and spectroscopy (UV-visible, FTIR and ESR) studies. The DNA binding studies of synthesized compounds were carried out and results suggest that, ligand L and its transition metal complexes 1-6 were binding to CT-DNA through intercalation. It was confirmed by intrinsic binding constant value in the order of 106 M-1. The fluorescence properties of ligand L and its metal complexes 1-6 were investigated; ligand showed broad emission spectra in the visible region and its metal complexes exhibited emission spectra in the blue to red.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Binucleating Hydrazonic Ligands and Their μ-Hydroxodicopper(II) Complexes as Promising Structural Motifs for Enhanced Antitumor Activity, the main research direction is crystal structure copper hydrazonophenol binucleating hydroxo; copper hydrazonophenol preparation antiproliferative activity BSA DNA binding.Category: benzisoxazole.

Very few inorganic antineoplastic drugs have entered the clinic in the last decades, mainly because of toxicity issues. Because Cu is an essential trace element of ubiquitous occurrence, decreased side effects could be expected in comparison with the widely used Pt anticancer compounds Two novel hydrazonic binucleating ligands and their μ-hydroxo dicopper(II) complexes were prepared and fully characterized. They differ by the nature of the aromatic group present in their aroylhydrazone moieties: while H3L1 and its complex [Cu2(μ-OH)(HL1)](ClO4) (1), possess a thiophene ring, H3L2 and [Cu2(μ-OH)(HL2)](ClO4) (2) contain the more polar furan heterocycle. X-ray diffraction indicates that both coordination compounds are very similar in structural terms and generate dimeric arrangements in the solid state. Pos.-ion electrospray ionization mass spectrometry analyses confirmed that the main species present in a 10% DMSO/water solution should be [Cu2(HL)(OH)]+ and the DMSO-substituted derivative [Cu2(L)(DMSO)]+. Scattering techniques [dynamic light scattering (DLS) and small-angle x-ray scattering] suggest that the complexes and their free ligands interact with bovine serum albumin (BSA) in a reversible manner. The binding constants to BSA were determined for the complexes through fluorescence spectroscopy. Also, to gain insight into the mechanism of action of the compounds, calf thymus DNA binding studies by UV-visible and DLS measurements using plasmid pBR322 DNA were also performed. For the complexes, DLS data seem to point to the occurrence of DNA cleavage to Form III (linear). Both ligands and their dicopper(II) complexes display potent antiproliferative activity in a panel of four cancer cell lines, occasionally even in the submicromolar range, with the complexes being more potent than the free ligands. The authors’ data on cellular models correlate quite well with the DNA interaction experiments The results presented herein show that aroylhydrazone-derived binucleating ligands, as well as their dinuclear μ-hydroxodicopper(II) complexes, may represent a promising structural starting point for the development of a new generation of highly active antitumor agents.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

HPLC of Formula: 3326-71-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Green aqueous synthesis and antimicrobial evaluation of 3,5-disubstituted 1,2,4-triazoles. Author is Beyzaei, Hamid; Malekraisi, Farideh; Aryan, Reza; Ghasemi, Behzad.

An eco-friendly and simple procedure was proposed for the synthesis of 3,5-disubstituted 1,2,4-triazoles I [R = Ph, 4-pyridyl, 2-furyl, etc.] by optimized reaction of benzamidine hydrochloride and various aryl hydrazides. The products were generated in good to high yields in one step and sufficient purity after a simple workup. Inhibitory activity of all prepared derivatives was evaluated against 10 pathogenic bacterial strains including both Gram-pos. and Gram-neg., as well as 2 mold and 1 yeast strains. The prepared derivatives showed good antimicrobial activities and 1,2,4-triazoles containing 2-hydroxynaphthalen-3-yl and 5-chlorothiophen-2-yl substituents at position 3 showed the best antifungal and antibacterial properties, resp.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics