Category: 3326-71-4

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3326-71-4, is researched, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2Journal, Polyhedron called Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands, Author is Dinda, Rupam; Panda, Arpita; Banerjee, Atanu; Mohanty, Monalisa; Pasayat, Sagarika; Tiekink, Edward R. T., the main research direction is molybdenum oxo Schiff arylhydrazone hydroxybenzaldehyde complex preparation redox potential; antitumor DNA binding molybdenum oxo Schiff arylhydrazone hydroxybenzaldehyde complex; crystal structure molybdenum oxo Schiff arylhydrazone hydroxybenzaldehyde complex.COA of Formula: C5H6N2O2.

Four new mixed ligand dioxidomolybdenum(VI) [MoVIO2L1-3(Q)] (1-3), [MoVIO2L4(Q)]2 (H2O) (4) [where Q = MeOH for 1 and imidazole for 2-4] complexes were synthesized using four different ONO donor aroylhydrazone ligands (H2L1-4). All the derived ligands and complexes were characterized by different physicochem. techniques, i.e., elemental anal., spectroscopic methods (UV-Vis, NMR and IR), and cyclic voltammetry. The mol. geometries of 1-4 were established by X-ray crystallog. which reveals the Schiff base ligands coordinate – the distorted octahedral metal centers in a di-neg. tridentate fashion. The complexes indicated moderate binding affinity (103 to 104 M-1) towards CT-DNA. Further, in vitro cytotoxicity activity of all the complexes were determined against HT-29 (colon cancer) and HeLa (cervical cancer) cell lines. Complex 4, due to the presence of a heterocyclic 2-hydroxy-1-naphthyl moiety in the ligand backbone, was found to be more biol. active in comparison to the others in the series.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about An efficient water-soluble fluorescent chemosensor based on furan Schiff base functionalized PEG for the sensitive detection of Al3+ in pure aqueous solution, the main research direction is water soluble fluorescent chemosensor furan Schiff base PEG aluminum.COA of Formula: C5H6N2O2.

Furan Schiff base functionalized PEG (PEGFB) was synthesized as an excellent reversible fluorescent chemosensor for the sensitive detection of Al3+ in 100% aqueous solution The non-fluorescent PEGFB displayed high selectivity towards Al3+ over other coexistent metal ions, accompanied by a visual fluorescence change from colorless to bright cyan. The detection limit of PEGFB towards Al3+ was determined to be 7.90 x 10-9 M. PEGFB could be utilized to detect Al3+ in a relatively wide pH range from 5 to 9. The reversible fluorescence response of PEGFB upon the addition of Al3+ and EDTA was successfully used to construct an INHIBIT mol. logic gate. Furthermore, test strips coated with PEGFB could be applied for the convenient and visual sensing of Al3+ in real water samples.

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Benzisoxazole – Wikipedia,
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HPLC of Formula: 3326-71-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Photophysics of proton transfer in hydrazides: a combined theoretical and experimental analysis towards OLED device application. Author is Mohan, Makesh; Satyanarayan, M. N.; Trivedi, Darshak R..

Hydrazides generate phototautomers and thus, a mechanistic interpretation to uncover the excited state dynamics of such systems is highly necessary to theorize principles based on exptl. speculations. Accordingly, focus on the proton transfer barrier, which is a questionable step-wise or hypothetical simultaneous double proton transfer on structurally favored species, is quintessential; however, to the best of our knowledge, theor. insights into such findings remain rare. Thus, TX, PX and FX (where X = 2 and 3) were designed and synthesized by incorporating hydrazides, which exhibit the phenomenon of excited state intramol. proton transfer (ESIPT). Some of the mols. exhibited electroluminescence when employed as an active emitter material in fabricated OLED devices. Theor. predictions support the presence of extended conjugation in TX, PX and FX (where X = 2 and 3) to support ESIPT efficiently in comparison with TX, PX and FX (where X = 1). The solvatochromic study revealed that TX, PX and FX (where X = 2 and 3) exhibit a distinct double peak in THF solvent, characteristic of ESIPT. Interestingly, for some of the mols., emission in thin film form showed a double peak, which indicates ESIPT in the solid state. However, it was found that aggregation induced emission (AIE) was inactive in these mols. The geometrical attributes of the mols. and the nature of electronic orbital distribution well underline the principle supporting excited state proton translocation. The theor. estimated energy transitions exhibited good correlation with the exptl. results. Also, the potential energy scans revealed the mols. possess a lower forward barrier at their excited state in comparison with that of their ground state, promoting ESIPT. The potential energy surface scans performed on structurally favored species confirmed the impossible double proton transfer and highly difficult step-wise double proton transfer.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

COA of Formula: C5H6N2O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Spatial structure, thermodynamics and kinetics of formation of hydrazones derived from pyridoxal 5′-phosphate and 2-furoic, thiophene-2-carboxylic hydrazides in solution.

The spatial structure of pyridoxal 5′-phosphate hydrazones of 2-furoic hydrazide; thiophene-2-carboxylic hydrazide in aqueous solution was studied by means of quantum chem. calculations and NOE experiment The hydrazones could exist as a mixture of different conformers; however, the specific ones could be suggested from exptl. and calculated data. The stability constants of hydrazones at pH of 1.9; 6.6; 7.0; 7.4 were determined using UV-Vis spectroscopy. Rate constants of the hydrazone formation and hydrolysis reaction within the range of 6.6-7.4 pH were obtained. Isothermal calorimetric titration was performed in order to determine the change in the free Gibbs energy, enthalpy and entropy of hydrazones formation at pH of 6.6. Hydrazones were synthesized and characterized by means of 1H, 13C, 31P NMR, IR, UV-Vis, fluorescent, MS-spectroscopy as well as DSC and elemental anal.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Recommanded Product: 2-Furoic hydrazide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis and anticancer activity of new ((furan-2-yl)-1,3,4-thiadiazolyl)-1,3,4-oxadiazole acyclic sugar derivatives.

New sugar hydrazones incorporating furan and/or 1,3,4-thiadiazole ring systems I (R1 = (S,S,R,R)-HOCH2(CHOH)3CH(OH) (A), (R,R,R)-HOCH2(CHOH)2CH(OH)) were synthesized by reaction of the corresponding hydrazide II with different aldose sugars. Heterocyclization of the formed hydrazones I afforded the derived acyclic nucleoside analogs III (R2 = (S,S,R,R)-HOCH2(CHOC(O)CH3)3CH(OH), (R,R,R)-H3C(O)COCH2(CHOC(O)CH3)2CH(OH)) possessing the 1,3,4-oxadiazoline as modified nucleobase via acetylation followed by the heterocyclization process. The anticancer activity of the synthesized compounds was studied against human liver carcinoma cell (HepG-2) and at human normal retina pigmented epithelium cells (RPE-1). High activities were revealed by compounds 4-(2-(furan-2-carbony!)hydrazinyl)-4-oxobutanoyl chloride, IV and (A) with IC50 values near to that of the reference drug doxorubicin.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Recommanded Product: 3326-71-4.Mhaidat, I.; Taha, Z. A.; Al Momani, W.; Hijazi, A. K. published the article 《Photoconductivity, Antioxidant, and Antimicrobial Activities of Some Acenaphthenequinone Derivatives》 about this compound( cas:3326-71-4 ) in Russian Journal of General Chemistry. Keywords: acenaphthenequinone preparation antibacterial antioxidant activity photoconductivity. Let’s learn more about this compound (cas:3326-71-4).

Photoconductive acenaphthenequinone derivatives I (R = thiophen-2-yl, 3-hydroxynaphthalen-2-yl, pyridin-4-yl, etc.) have been synthesized by a one-pot process of acenaphthenequinone with different aromatic hydrazides RC(O)NHNH2. Photoelectrochem. (PEC) measurements reveal that the compounds demonstrate photoresponse upon illumination by light of intensities 1000 and 10000 W/m2. The photoconductivity behavior of the derivatives I is enhanced in the presence of electron donor groups attached to the aromatic ring. Thereby, these products may be used in material devices as organic thin film transistors, on/off sensors, etc. The antioxidant activity of the products has been tested by DPPH radical scavenging method in vitro, indicating their significant potential. Antimicrobial activity of the derivatives I has been estimated by min. inhibitory concentration (MIC, mg/mL) using the micro-broth dilution method. The compounds are moderately active against some Gram pos. bacteria and Candida albicans and completely inactive against Gram neg. bacteria tested.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Application In Synthesis of 2-Furoic hydrazide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Electrochemical Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from α-Keto Acids and Acylhydrazines Under Mild Conditions. Author is Lu, Fangling; Gong, Fengping; Li, Liangsen; Zhang, Kan; Li, Zhen; Zhang, Xinwei; Yin, Ying; Wang, Ying; Gao, Ziwei; Zhang, Heng; Lei, Aiwen.

1,3,4-Oxadiazoles are a kind of useful heterocycles which can be frequently found in materials and bioactive mols. In this study, intermol. electrochem. cyclization between α-keto acids and acylhydrazines has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles with the yield up to 91% [e.g., benzohydrazide + 2-oxo-2-phenylacetic acid → 2,5-diphenyl-1,3,4-oxadiazole (90%)]. This transformation can be run under mild reaction conditions in the absence of external oxidant, base and transition metal catalyst. Both sym. and unsym. 2,5-disubstituted 1,3,4-oxadiazoles could be prepared according to the careful choice of the substrate combination. Gram scale synthesis also illustrates the potential application of this protocol in large preparation

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Phosphine-Free Ruthenium Complex-Catalyzed Synthesis of Mono- or Dialkylated Aryl Hydrazides via the Borrowing Hydrogen Strategy, the main research direction is aryl hydrazide alkylation alc ruthenium catalyst.Formula: C5H6N2O2.

A diaminocyclopentadienone ruthenium tricarbonyl complex-catalyzed synthesis of mono- or dialkylated aryl hydrazides from N-unsubstituted aryl hydrazides and various substituted primary and secondary alcs. as alkylating reagents using the borrowing hydrogen strategy has been developed. Deuterium labeling experiments confirmed that the alcs. are the hydride source in this cascade process. D. functional theory (DFT) calculations unveiled the origin and the threshold between the mono- and dialkylation.

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Benzisoxazole – Wikipedia,
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Singh, Dharmender; Tiwari, Sandip Kumar; Singh, Virender published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).HPLC of Formula: 3326-71-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

An efficient protocol were developed for one-pot synthesis of biol. interesting β-carboline substituted 1,3,4-oxadiazoles via an I2-assisted oxidative C-O bond formation strategy. This metal-free sequential approach was found to be compatible with diversely substituted 1-formyl β-carbolines and aromatic as well as aliphatic hydrazides, providing access to a variety of multifunctional β-carboline linked 1,3,4-oxadiazole derivatives in good to excellent yields. The methodol. was found to be applicable to gram scale synthesis of β-carboline substituted 1,3,4-oxadiazole derivatives Addnl., β-carboline C1 linked 2-amino-1,3,4-oxadiazoles and bis-1,3,4-oxadiazoles were also synthesized using the same strategy.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Rani Gupta, Shraddha; Yadav, Pranjalee; Singh, Priya; Koch, Biplob; Singh, Vinod P. published the article 《A “”Turn-On”” Fluorescence Probe for Selective Detection of Al3+ in Aqueous Environment: Crystal Structure, Theoretical and Cell Imaging Studies》. Keywords: lung cancer aluminum water soluble fluorescent probe furan.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Safety of 2-Furoic hydrazide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.

A furan-based water soluble fluorescent probe (E)-N′-(2,4-dihydroxybenzylidene)furan-2-carbohydrazide (DBF) has been synthesized and characterized by 1H NMR, 13C NMR, ESI-mass spectroscopy and single crystal X-ray diffraction techniques. The synthesized probe exhibits a “”turn-on”” fluorescence response towards Al3+ in Tris-HCl buffer (10 mM) with no significant interference from other metal ions. The strong fluorescence in the presence of Al3+ is attributed to the CHEF (chelation enhanced fluorescence), inhibition of PET (photo-induced electron transfer) and C=N isomerization. 1 : 1 stoichiometric ratio between DBF and Al3+ was rationalized by Job′s plot. Binding constant and LOD were calculated to be 1.031×105 M-1 and 6.34×10-8 M, resp. MTT assay on live A549 cells indicated no serious cytotoxicity in the cells even at higher concentration Further, DBF was successfully used for the detection of accumulated Al3+ in the cytoplasm of cells.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics