Category: 3326-71-4

Aydin, Duygu; Gunay, Ibrahim Berk; Karuk Elmas, Sukriye Nihan; Savran, Tahir; Arslan, Fatma Nur; Sadi, Gokhan; Yilmaz, Ibrahim published the article 《A simple and sensitive fluorescent sensor platform for Al3+ sensing in aqueous media and monitoring through combined PET and ESIPT mechanisms: practical applications in drinking water and bio-imaging》. Keywords: fluorescent sensor aluminum bioimging.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Product Details of 3326-71-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.

In this study, a novel hydrazide-based compound, (E)-N′-(5-(benzo[d]thiazol-2-yl)-2-hydroxybenzylidene)furan-2-carbohydrazide (probe BOTH, I) was designed, characterized and prepared as a fluorogenic “”turn-on”” sensor for monitoring Al3+ in near-perfect aqueous media. All emission and absorbance spectral studies were performed in HEPES/DMSO (volume/volume, 99.95/0.05, pH = 7.0) media at 25 °C. The quantum yield of probe BOTH increases considerably in the presence of Al3+. Probe BOTH could sense Al3+ at a concentration as low as 6.47 nM. Probe BOTH could sense Al3+ with high sensitivity and selectivity, and a quant. correlation of R2 = 0.9887 in the Al3+ concentration range of 0.0-20.0 equivalent To evaluate the method parameters, a validation study was performed based on different anal. parameters. The formation of complex BOTH-Al3+ (2 : 1 stoichiometry) was confirmed by 1H-NMR titration and MALDI-TOF MS, as well as Job′s methods. pH-Dependent and Benesi-Hildebrand plot studies also supported this proposed sensing mechanism. Besides, the binding mechanism of Al3+ with probe BOTH was further verified by theor. studies. Moreover, probe BOTH could be used for monitoring Al3+ in living-cells and water samples.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Ultrasound mediated efficient synthesis of new 4-oxoquinazolin-3(4H)-yl)furan-2-carboxamides as potent tyrosinase inhibitors: Mechanistic approach through chemoinformatics and molecular docking studies.COA of Formula: C5H6N2O2.

Synthesis of new (4-oxoquinazolin-3(4H)-yl)furan-2-carboxamide derivatives I [R = H, 5-Br, 3-NO2, etc.] via p-TSA catalyzed reaction between isatoic anhydride, 2-furoic hydrazide and substituted salicylaldehydes in ethanol:water (5:5 volume/volume) solvent system under ultrasound irradiation at room temperature was carried out. The important features of this protocol were simple and easy workup procedure, reaction carried out at ambient temperature, use of ultrasound and high yield of (4-oxoquinazolin-3(4H)-yl)furan-2-carboxamides in short reaction time. The synthesized compounds I were screened against tyrosinase enzyme and all these compounds found to be potent inhibitors with much lower IC50 value of 0.028 ± 0.016 to 1.775 ± 0.947 μM than the standard kojic acid (16.832 ± 1.162 μM). The kinetics mechanism for compound I [R = 3,5-di-Br] was analyzed by Lineweaver-Burk plots which revealed that compound inhibited tyrosinase non-competitively by forming an enzyme-inhibitor complex. Along with this all the synthesized compounds I were scanned for their DPPH free radical scavenging ability. The outputs received through in vitro and in silico anal. were coherent to the each other with good binding energy values (kcal/mol) posed by synthesized ligands.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Recommanded Product: 3326-71-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about A 2-Hydroxy-1-naphthaldehyde Schiff Base for Turn-on Fluorescence Detection of Zn2+ Based on PET Mechanism. Author is Mu, Xinyue; Shi, Liping; Yan, Liqiang; Tang, Ningli.

Zinc ion is closely related to human health. Its content in human body is small, while the effect is large. However, it is not the more the better, must be in a scientific balance. Therefore, it is significant to the rapid detection of Zn2+ in the environment and organism. Herein, a fluorescent probe based on 2-hydroxy-1-naphthalene formaldehyde and furan-2-carbohydrazide was conveniently synthesized via Schiff base reaction. And this probe has been successfully applied to the accurate and quant. detection of Zn2+ in real samples, showing turn on fluorescence, good selectivity, very low detection limit, real time response and reusability. In addition, this probe has the potential application to trace Zn2+ in living cells with low cytotoxicity.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis, antimicrobial and antioxidant evaluation, and molecular docking study of 4,5-disubstituted 1,2,4-triazole-3-thiones, the main research direction is triazole thione preparation docking antibacterial antifungal antioxidant activity.Name: 2-Furoic hydrazide.

In order to develop potential antimicrobial agents, some 1,2,4-triazole-3-thiones I (R = Et, Ph, 4-nitrophenyl, etc.; Ar = Ph, furan-2-yl, pyridin-4-yl, etc.) were synthesized from the reaction of hydrazides ArC(O)NHNH2 with isothiocyanates RN=C=S under optimized conditions in deep eutectic solvent of potassium carbonate-glycerol (1:5 M ratio). Blocking properties of all products were assessed on a variety of Gram-pos. and Gram-neg. bacterial as well as fungal pathogens. Good to excellent inhibitory effects especially against fungi were observed with all synthesized compounds Compound I (R = 4-nitrophenyl; Ar = 4-hydroxyphenyl) showed significant antioxidant activity according to the results obtained from 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging experiments The possible interaction mechanism of synthetic triazoles with 1IYL enzyme on Aspergillus fumigatus was investigated by mol. docking method. A complete agreement was found between exptl. data and theor. calculations Hydrogen bond acceptor strength of N-1 in 1,2,4-triazole rings was the main cause of the observed differences.

From this literature《Synthesis, antimicrobial and antioxidant evaluation, and molecular docking study of 4,5-disubstituted 1,2,4-triazole-3-thiones》,we know some information about this compound(3326-71-4)Name: 2-Furoic hydrazide, but this is not all information, there are many literatures related to this compound(3326-71-4).

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Related Products of 3326-71-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis of Acyl Phosphoramidates Employing a Modified Staudinger Reaction. Author is Currie, Iain; Sleebs, Brad E..

A 1-step synthesis of acyl phosphoramidates from a variety of functionalized acyl azides was developed employing trimethylsilyl chloride as an activating agent in a modified Staudinger reaction. The methodol. was further adapted to include the in situ generation of the acyl azides from a diverse selection of carboxylic acids and hydrazide starting synthons. The reaction scope was extended to include the synthesis of imidodiphosphates and the natural product Microcin C.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

HPLC of Formula: 3326-71-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about DMF as Methine Source: Copper-Catalyzed Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles. Author is Wang, Shoucai; Wang, Kai; Kong, Xiangfei; Zhang, Shuhua; Jiang, Guangbin; Ji, Fanghua.

An unprecedented Cu-catalyzed direct annulation of hydrazides with N,N-dimethylformamide (DMF) was developed, providing an efficient synthesis of valuable 1,3,4-oxadiazoles. This process featured short reaction time and safely conducted on gram scale. The reaction also facilitated the convenient synthesis of 1,3,4-oxadiazole-2(3H)-ones. Moreover, the mechanistic studies suggested that the source of CH was from the N-Me group of DMF.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Related Products of 3326-71-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about A 2-Hydroxy-1-naphthaldehyde Schiff Base for Turn-on Fluorescence Detection of Zn2+ Based on PET Mechanism. Author is Mu, Xinyue; Shi, Liping; Yan, Liqiang; Tang, Ningli.

Zinc ion is closely related to human health. Its content in human body is small, while the effect is large. However, it is not the more the better, must be in a scientific balance. Therefore, it is significant to the rapid detection of Zn2+ in the environment and organism. Herein, a fluorescent probe based on 2-hydroxy-1-naphthalene formaldehyde and furan-2-carbohydrazide was conveniently synthesized via Schiff base reaction. And this probe has been successfully applied to the accurate and quant. detection of Zn2+ in real samples, showing turn on fluorescence, good selectivity, very low detection limit, real time response and reusability. In addition, this probe has the potential application to trace Zn2+ in living cells with low cytotoxicity.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Recommanded Product: 3326-71-4.Ferreira, Ricardo J.; Gajdacs, Mario; Kincses, Annamaria; Spengler, Gabriella; dos Santos, Daniel J. V. A.; Ferreira, Maria-Jose U. published the article 《Nitrogen-containing naringenin derivatives for reversing multidrug resistance in cancer》 about this compound( cas:3326-71-4 ) in Bioorganic & Medicinal Chemistry. Keywords: preparation nitrogen containing naringenin derivative reversing multidrug resistance cancer; Docking; Efflux modulators; Flavonoids; Molecular dynamics; Multidrug resistance; P-glycoprotein. Let’s learn more about this compound (cas:3326-71-4).

Naringenin (1), isolated from Euphorbia pedroi, was previously derivatized yielding compounds 2-13. In this study, aiming at expanding the pool of analogs of the flavanone core towards better multidrug resistance (MDR) reversal agents, alkylation reactions and chem. modification of the carbonyl moiety was performed (15-39). Compounds structures were assigned mainly by 1D and 2D NMR experiments Compounds 1-39 were assessed as MDR reversers, in human ABCB1-transfected mouse T-lymphoma cells, overexpressing P-glycoprotein (P-gp). The results revealed that O-methylation at C-7, together with the introduction of nitrogen atoms and aromatic moieties at C-4 or C-4′, significantly improved the activity, being compounds 27 and 37 the strongest P-gp modulators and much more active than verapamil. In combination assays, synergistic interactions of selected compounds with doxorubicin substantiated the results. While mol. docking suggested that flavanone derivatives act as competitive modulators, mol. dynamics showed that dimethylation promotes binding to a modulator-binding site. Moreover, flavanones may also interact with a vicinal ATP-binding site in both nucleotide-binding domains, hypothesizing an allosteric mode of action.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Iodine-promoted one-pot synthesis of 1,3,4-oxadiazole scaffolds via sp3 C-H functionalization of azaarenes, the main research direction is diaryl oxadiazole preparation; acylhydrazine methyl azaarene iodine base mediated oxidative amination cyclization.Application In Synthesis of 2-Furoic hydrazide.

An efficient iodine-mediated one-pot synthetic protocol for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles scaffolds I [R = 2-furyl, Ph, 4-ClC6H4, etc.; R1 = 2-pyridyl, 2-quinolinyl, 7-Clquinolin-2-yl, etc.] was developed via sp3 C-H functionalization. This method involved oxidative amination with concomitant base-mediated cyclization of methylhetarenes and acylhydrazines by employing iodine and Cs2CO3. The key features of the present method included good functional group tolerance, a clean protocol, metal-free conditions and high yields, making this protocol an attractive strategy toward the synthesis of bioactive mols. and their key building blocks.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Canal-Martin, Andrea; Navo, Claudio D.; Saez, Elena; Molero, Dolores; Jimenez-Oses, Gonzalo; Perez-Fernandez, Ruth researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Related Products of 3326-71-4.They published the article 《Nucleophilic catalysis of p-substituted aniline derivatives in acylhydrazone formation and exchange》 about this compound( cas:3326-71-4 ) in Organic & Biomolecular Chemistry. Keywords: phenylimino phenol preparation; hydroxy nitrobenzaldehyde acylhydrazide imine catalyst nucleophilic addition reaction; nitrobenzylidene acylhydrazone preparation mechanism kinetics. We’ll tell you more about this compound (cas:3326-71-4).

A mechanistic study and superior performance of electron-rich p-substituted aniline derivatives as catalysts for efficient hydrazone formation and exchange in both protic and aprotic solvents was reported. Rigorous kinetic analyses demonstrate that imine formation with 3-hydroxy-4-nitrobenzaldehyde and aniline derivatives proceeds with unprecedented third-order kinetics in which the aldehyde consistently shows a partial order of two. Computational investigations provide insights into the mechanisms of these transformations.

If you want to learn more about this compound(2-Furoic hydrazide)Related Products of 3326-71-4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(3326-71-4).

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics