Category: 3326-71-4

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Name: 2-Furoic hydrazide.Peng, Hua-nan; Liu, Yi-qing; Huang, Jia-qi; Huang, Shou-Shun; Cai, Xin-ping; Xu, Shu-juan; Huang, Ai; Zeng, Qiang; Xu, Miao published the article 《A simple fluorescent probe for selective detection of Al3+ based on furan Schiff base and its crystal structure》 about this compound( cas:3326-71-4 ) in Journal of Molecular Structure. Keywords: aluminum furan Schiff base crystal structure fluorescent probe sensor. Let’s learn more about this compound (cas:3326-71-4).

A simple “”turn-on”” fluorescent probe L was synthesized by condensation of furan-2-carbohydrazide and 2-hydroxy-4-methoxybenzaldehyde, and its structure was confirmed by single crystal X-ray diffraction. The probe L exhibited excellent selectivity towards Al3+ over other coexistent metal ions with remarkable fluorescence enhancement, accompanied by color change from colorless to blue. Moreover, the probe L showed high sensitivity to Al3+ with low detection limit (3.10 x 10-8 M) in the pH range of 3.0-8.0. The possible sensing mechanisms of L toward Al3+ were determined by Job plots experiments, high resolution mass spectrometry (HRMS), 1H NMR spectra and the d. functional theory (DFT) calculations Addnl., the probe L was successfully applied for detection of Al3+ in water samples with satisfactory results.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Organoruthenium (II) complexes featuring pyrazole-linked Schiff base ligands: Crystal structure, DNA/BSA interactions, cytotoxicity and molecular docking, the main research direction is ruthenium arene half sandwich pyrazole Schiff base complex preparation; DNA protein intercalation ruthenium arene pyrazole Schiff base complex; crystal structure ruthenium arene pyrazole Schiff base complex; mol structure ruthenium arene pyrazole Schiff base complex.Application of 3326-71-4.

Half-sandwiched ruthenium (II) arene complexes with piano stool-like geometry with the general formula [(p-cymene)RuClL1] and [(p-cymene)RuClL2] [where L1 = (Z)-N’-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)furan-2-carbohydrazide and L2 = (Z)-N’-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)thiophene-2-carbohydrazide] were synthesized and characterized. The single crystal X-ray data revealed that the complexes belong to the same crystal system (monoclinic) with octahedral geometry, where the ruthenium atom is surrounded by hydrazone ligand coordinated through ON atoms, one chloride labile co-ligand and the remaining three coordination sites covered by an electron cloud of p-cymene moiety. The interaction between the complexes and DNA/bovine serum albumin (BSA) was evaluated using absorption and emission titration methods showing intercalative modes of interaction. The DNA cleavage ability of the complexes was checked by agarose gel electrophoresis method exhibiting the destruction of DNA duplex arrangement. To understand the interaction between ruthenium complex and DNA/BSA mol., mol. docking studies were performed. In vitro cytotoxicity of the complexes was examined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on human lung cancer cell line, A549, and found that at lower IC50, cell growth inhibition has occurred. Similarly, the IC50 values of the complexes treated with cancerous cell lines have produced a significant amount of lactase dehydrogenase and nitrite content in the culture medium, which were evaluated as apoptosis-inducing factors, suggesting that the ruthenium (II) arene hydrazone complexes with pyrazole ligands have promising anticancer activities.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called In vitro evaluations of biomolecular interactions, antioxidant and anticancer activities of Nickel(II) and Copper(II) complexes with 1:2 coordination of anthracenyl hydrazone ligands, published in 2021-09-01, which mentions a compound: 3326-71-4, Name is 2-Furoic hydrazide, Molecular C5H6N2O2, Product Details of 3326-71-4.

A set of nickel(II) and copper(II) complexes incorporated anthracenyl hydrazone ligands were synthesized and characterized with the help of various spectroscopic techniques. Single-crystal XRD studies revealed that all four complexes have square planar geometry in which the hydrazones are coordinated through NO atoms with 1:2 metal to ligand stoichiometry. Bio-mol. interactions of these complexes were analyzed using UV and emission spectroscopic studies, which revealed that compounds interact with calf thymus DNA (CT-DNA) through intercalation and also bind strongly with BSA. This further has been confirmed by theor. studies. Anticancer nature of the compounds was evaluated with the help of MTT assay against colon cancer cells (HCT-15) and normal skin cells (L929). It is verified that the complexes showed excellent cytotoxicity to cancer cells whereas negligible toxicity towards normal cells. Antioxidant activity was checked by DPPH radical scavenging assay and found that the complexes are capable of reducing available radicals. The complexes initiated cell death via reactive oxygen species generation was determined by ROS assay. The morphol. transformations observed in cell lines treated with different concentrations of complexes have been observed with the help of SEM (SEM). Flow cytometric anal. expressed that the synthesized complexes can induce apoptotic cell death, hence eligible for further studies.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Quality Control of 2-Furoic hydrazide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthetic stratagem, characterization and biocidal applications of triorganotin(IV) complexes derived from hydrazide/hydrazone analogues. Author is Mehmood, Mehwish; Imtiaz-ud-Din; Nawaz Tahir, Muhammad; Haq, Ihsan-ul; Zahra, Syeda Saniya.

A series of Schiff base ligands as benzylidene benzohydrazide and their hydrazone analogs (Ia-Ic) have been synthesized and then complexed with organotin(IV) moiety having general formula [R’3SnL] to get the target compounds (1-9), where L = C4H3OCONHN:CHR, R = C6H5O (Ia), C4H5O (Ib), C6H3Cl2 (Ic) and R’ = -CH3 (1-3), -CH2Ph (4-6), -Ph (7-9). They were fully characterized using FT-IR, NMR (1H, 13C and 119Sn) spectroscopy, along with elemental anal. and m.p. One of the precursor (Ib) has been analyzed by single crystal XRD to further authenticate the structure. The 119Sn NMR data suggest the mol. geometry of organotin derivatives as distorted pentagonal bipyramidal. They were also evaluated for their antibacterial, antifungal, α-amylase inhibition, DPPH, total reducing power and total antioxidant activities. Triaryltin(IV) derivatives show good antibacterial and antifungal activity. Whereas the data for antidiabetic activity demonstrated that the compounds may serve as moderately effective alpha amylase inhibitor.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Product Details of 3326-71-4.Beyzaei, Hamid; Ghanbari Kudeyani, Maryam; Samareh Delarami, Hojat; Aryan, Reza published the article 《Synthesis, antimicrobial and antioxidant evaluation, and molecular docking study of 4,5-disubstituted 1,2,4-triazole-3-thiones》 about this compound( cas:3326-71-4 ) in Journal of Molecular Structure. Keywords: triazole thione preparation docking antibacterial antifungal antioxidant activity. Let’s learn more about this compound (cas:3326-71-4).

In order to develop potential antimicrobial agents, some 1,2,4-triazole-3-thiones I (R = Et, Ph, 4-nitrophenyl, etc.; Ar = Ph, furan-2-yl, pyridin-4-yl, etc.) were synthesized from the reaction of hydrazides ArC(O)NHNH2 with isothiocyanates RN=C=S under optimized conditions in deep eutectic solvent of potassium carbonate-glycerol (1:5 M ratio). Blocking properties of all products were assessed on a variety of Gram-pos. and Gram-neg. bacterial as well as fungal pathogens. Good to excellent inhibitory effects especially against fungi were observed with all synthesized compounds Compound I (R = 4-nitrophenyl; Ar = 4-hydroxyphenyl) showed significant antioxidant activity according to the results obtained from 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging experiments The possible interaction mechanism of synthetic triazoles with 1IYL enzyme on Aspergillus fumigatus was investigated by mol. docking method. A complete agreement was found between exptl. data and theor. calculations Hydrogen bond acceptor strength of N-1 in 1,2,4-triazole rings was the main cause of the observed differences.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about Crystal structure of N′-[4-(dimethylamino)benzylidene]furan-2-carbohydrazide monohydrate, the main research direction is furoic hydrazide dimethyl aminobenzaldehyde crystal structure; crystal structure; furoic acid; hydrazide; hydrazone.Electric Literature of C5H6N2O2.

The condensation of 2-furoic hydrazide and 4-dimethyl aminobenzaldehyde in ethanol yielded a yellow solid formulated as the title compound, C14H15N3O2·H2O. The crystal packing is stabilized by intermol. O(water)-H···O,N(carbohydrazide) and N-H···O(water) hydrogen bonds, which form a two-dimensional network along the bc plane. Addnl. C-H···O interactions link the mols. into a three-dimensional network. The dihedral angle between the mean planes of the benzene and the furan ring is 34.47 (6)°. The carbohydrazide moiety, i.e., the C=N-N-C=O fragment and the benzene ring are almost coplanar, with an angle of 6.75 (9)° between their mean planes.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, ChemistrySelect called Deciphering of Ligand-to-Metal Charge-Transfer Process: Synthesis, Spectroscopic and Theoretical Study, Author is Ghosh, Swadesh; Singharoy, Dipti; Naskar, Jnan Prakash; Bhattacharya, Subhash Chandra, which mentions a compound: 3326-71-4, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2, Formula: C5H6N2O2.

Many reports on metal ion sensing applications are available in literature but the mechanism of selectivity is not clear. Here the synthesis and characterization of a Schiff base Furan-2-carboxylic acid pyren-1-ylmethylene-hydrazide (PYFH) has been described with selective detection of copper(II) metal ion among different metal ions by UV-vis, fluorescence and HRMS spectroscopic methods. The S2- ion (Na2S) was added to the PYFH:Cu2+ complex for checking reversibility of PYFH by fluorescence, fluorescence microscopic imaging and mol. logic gate construction (combination of NOT and OR gate). From the exptl. findings the reason for selectivity of Cu2+ metal ion among a series of metal ions is not clear. So, to explore the causes of selectivity of Cu2+ metal ion by PYFH, D. Functional Theory (DFT) calculation was conducted for free PYFH and various sets of metal ions individually with PYFH. From DFT calculation it was understandable that selectivity of PYFH towards Cu2+ ions occurred due to lowering of HOMO-LUMO energy of PYFH:Cu2+ composites (-8.46 & -5.80 eV) compared to free PYFH (-5.56 & -2.15 eV). Whereas energy of HOMO and LUMO with other metals ions (PYFH:Mn+) are ∼-5.50 and ∼-2.24 eV resp., as a result PYFH does not get any extra stability.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Facile synthesis, characterization, nucleic acid interaction and photoluminescent properties of (E)-furan-2-yl(2-(2-hydroxybenzylidene)hydrazinyl) methaniminium and its Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes, published in 2019-02-15, which mentions a compound: 3326-71-4, mainly applied to transition metal furanyl hydroxybenzylidene hydrazinylmethaniminium complex preparation photoluminescence; DNA binding transition metal furanyl hydroxybenzylidene hydrazinylmethaniminium complex; EPR spectra transition metal furanyl hydroxybenzylidene hydrazinylmethaniminium complex, Recommanded Product: 3326-71-4.

The present work describes the synthesis of novel (E)-furan-2-yl(2-(2-hydroxybenzylidene)hydrazinyl) methaniminium in water/methanol(3:1) mixture, water acting as catalyst and also solvent to expedite reaction rate with high yield. In which, amine exchange and condensation reaction takes place between N-salicylidene aniline and furanoic acid hydrazide at one step. The structural characterization of prepared ligand was carried out by single crystal x-ray diffraction, elemental anal. and spectroscopy (UV-visible, FTIR and NMR) techniques. The single crystal x-ray diffraction result indicates that the ligand crystallizes in orthorhombic system with Pca21 space group. Further, Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes of ligand were prepared Complexes were analyzed by elemental anal., magnetic susceptibility and spectroscopy (UV-visible, FTIR and ESR) studies. The DNA binding studies of synthesized compounds were carried out and results suggest that, ligand L and its transition metal complexes 1-6 were binding to CT-DNA through intercalation. It was confirmed by intrinsic binding constant value in the order of 106 M-1. The fluorescence properties of ligand L and its metal complexes 1-6 were investigated; ligand showed broad emission spectra in the visible region and its metal complexes exhibited emission spectra in the blue to red.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Prabakaran, G.; Manivarman, S.; Bharanidharan, M. researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Product Details of 3326-71-4.They published the article 《Catalytic synthesis, ADMET, QSAR and molecular modeling studies of novel chalcone derivatives as highly potent antioxidant agents》 about this compound( cas:3326-71-4 ) in Materials Today: Proceedings. Keywords: chalcone derivative antioxidant agent. We’ll tell you more about this compound (cas:3326-71-4).

A series of (E)-3-(3-(5-chlorothiophen-2-yl)-1-(furan-2-carbonyl)-2,3-dihydro-1H-pyrazol-4-yl)-1-(substituted)prop-2-en-1-one derivatives 5a-c was synthesized from the reaction of 3-(5-chlorothiophen-2-yl)-1-(furan-2-carbonyl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde (2) with various substituted acetophenes by the use of TiO2-ZnS in ethanol under reflux conditions. All are structurally supported by IR spectrum and the basic testing and screening, and find that compounds 5a are potential antioxidants for their in vitro-antioxidant activity against DPPH. The results in vitro were compared with the results of the mol. docking, ADMET, QSAR and bioactivity study and it was found that the results were observed in good correlations with in vitro anti-oxidant results in silicon binding affinities. The anal. of mol. dockings revealed the interactions between the synthesized ligands and protein tyrosine kinase (2HCK) amino acid residues and has a strong hydrogen connexion to this enzyme.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3326-71-4, is researched, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2Journal, Russian Journal of Organic Chemistry called Modification of Monocarboxylic Acid Hydrazides with Tropylium Salts, Author is Yunnikova, L. P.; Esenbaeva, V. V., the main research direction is hydrazide tropylium salt modification.Application In Synthesis of 2-Furoic hydrazide.

Nicotinic, isonicotinic, and furan-2-carboxylic acid hydrazides reacted with 2 equiv of tropylium perchlorate or tetrafluoroborate to give the corresponding N’N’-di(cyclohepta-2,4,6-trein-1-yl) derivatives as a result of electrophilic substitution of both hydrogen atoms in the primary amino group. The reaction of furan-2-carbohydrazide with an equimolar amount of tropylium salt gave N’-(cyclohepta-2,4,6-trien-1-yl)furan-2-carbohydrazide.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics