Category: 3326-71-4

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Russian Journal of General Chemistry called Photoconductivity, Antioxidant, and Antimicrobial Activities of Some Acenaphthenequinone Derivatives, Author is Mhaidat, I.; Taha, Z. A.; Al Momani, W.; Hijazi, A. K., which mentions a compound: 3326-71-4, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2, Category: benzisoxazole.

Photoconductive acenaphthenequinone derivatives I (R = thiophen-2-yl, 3-hydroxynaphthalen-2-yl, pyridin-4-yl, etc.) have been synthesized by a one-pot process of acenaphthenequinone with different aromatic hydrazides RC(O)NHNH2. Photoelectrochem. (PEC) measurements reveal that the compounds demonstrate photoresponse upon illumination by light of intensities 1000 and 10000 W/m2. The photoconductivity behavior of the derivatives I is enhanced in the presence of electron donor groups attached to the aromatic ring. Thereby, these products may be used in material devices as organic thin film transistors, on/off sensors, etc. The antioxidant activity of the products has been tested by DPPH radical scavenging method in vitro, indicating their significant potential. Antimicrobial activity of the derivatives I has been estimated by min. inhibitory concentration (MIC, mg/mL) using the micro-broth dilution method. The compounds are moderately active against some Gram pos. bacteria and Candida albicans and completely inactive against Gram neg. bacteria tested.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthetic stratagem, characterization and biocidal applications of triorganotin(IV) complexes derived from hydrazide/hydrazone analogues, the main research direction is triorganotin benzylidene benzohydrazide preparation antibacterial antifungal antidiabetic activity; alpha amylase inhibitor triorganotin benzylidene benzohydrazide complex; furanylmethylene furancarbohydrazide preparation crystal mol structure.COA of Formula: C5H6N2O2.

A series of Schiff base ligands as benzylidene benzohydrazide and their hydrazone analogs (Ia-Ic) have been synthesized and then complexed with organotin(IV) moiety having general formula [R’3SnL] to get the target compounds (1-9), where L = C4H3OCONHN:CHR, R = C6H5O (Ia), C4H5O (Ib), C6H3Cl2 (Ic) and R’ = -CH3 (1-3), -CH2Ph (4-6), -Ph (7-9). They were fully characterized using FT-IR, NMR (1H, 13C and 119Sn) spectroscopy, along with elemental anal. and m.p. One of the precursor (Ib) has been analyzed by single crystal XRD to further authenticate the structure. The 119Sn NMR data suggest the mol. geometry of organotin derivatives as distorted pentagonal bipyramidal. They were also evaluated for their antibacterial, antifungal, α-amylase inhibition, DPPH, total reducing power and total antioxidant activities. Triaryltin(IV) derivatives show good antibacterial and antifungal activity. Whereas the data for antidiabetic activity demonstrated that the compounds may serve as moderately effective alpha amylase inhibitor.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Quality Control of 2-Furoic hydrazide.Haribabu, Jebiti; Srividya, Swaminathan; Umapathi, Reddicherla; Gayathri, Dasararaju; Venkatesu, Pannuru; Bhuvanesh, Nattamai; Karvembu, Ramasamy published the article 《Enhanced anticancer activity of half-sandwich Ru(II)-p-cymene complex bearing heterocyclic hydrazone ligand》 about this compound( cas:3326-71-4 ) in Inorganic Chemistry Communications. Keywords: cymene ruthenium indole hydrazone preparation crystal mol structure; anticancer half sandwich ruthenium cymene heterocyclic hydrazone complex. Let’s learn more about this compound (cas:3326-71-4).

The hydrazone ligand (HL) was synthesized from furan-2-carbohydrazide and indole-3-carboxaldehyde. The reaction of [RuCl2(p-cymene)]2 with HL in the presence of sodium methoxide yielded organometallic Ru(II)-p-cymene compound of the type [RuCl(η6-p-cymene)(η2-N,O-indole hydrazone)] (1). The ligand and complex were characterized by CHN anal. and various spectroscopic tools. The piano stool (pseudo-octahedral) geometry of the complex was confirmed by single crystal x-ray diffraction. The anticancer property of the ligand and complex was investigated against A549, HeLa and MCF7 cancer cell lines. The complex exhibited superior activity against A549 and HeLa cancer cells with the IC50 values of 23.4 and 12.9μM, resp.

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Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, antioxidant and antitumor activities of some of new cyclobutane containing triazoles derivatives, published in 2019, which mentions a compound: 3326-71-4, Name is 2-Furoic hydrazide, Molecular C5H6N2O2, Formula: C5H6N2O2.

Thiosemicarbazides were obtained by the interaction of furan-2-carboxylic acid hydrazide with five different isothiocyanate (RNCS) derivatives By addition of KOH to the reaction medium, 1,2,4-triazoles derivatives I [R = Et, allyl, Ph, benzyl, 4-MeC6H4] were obtained. Compounds I were dissolved in dry acetone containing K2CO3 in the presence of 2-chloro-1-(3-methyl-3-mesitylcyclobutyl)ethanone to give 3,4,5-trisubstituted 1,2,4-triazole sulfanyl compounds II. The structures of the final compounds were confirmed by elemental analyses, FT-IR, 1H-NMR and 13C-NMR. The antioxidant and antitumor properties of the synthesized compounds were also investigated. Three of the triazole derivatives II [R = Ph, benzyl, 4-MeC6H4] displayed good antioxidant and antitumor activity in comparison to the standards

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Furoic hydrazide(SMILESS: O=C(C1=CC=CO1)NN,cas:3326-71-4) is researched.Safety of Palladium(II) acetate. The article 《Design and synthesis of new pyranoquinolinone heteroannulated to triazolopyrimidine of potential apoptotic antiproliferative activity》 in relation to this compound, is published in Bioorganic Chemistry. Let’s take a look at the latest research on this compound (cas:3326-71-4).

Pyrano[3,2-c]quinoline derivatives have been synthesized and utilized to obtain various new hetero-annulated triazolopyrimidine, containing quinoline, pyran, 1,2,4-triazine and pyrimidine in good yields. Newly synthesized compounds have been characterized by spectral data and elemental anal. Most of the synthesized compounds showed moderate to weak antiproliferative activity on most cancer cell lines, especially leukemia and breast cancer cell lines. The open chain formimidic acid Et ester is slightly more potent than hetero-annulated systems. The most active compounds were further investigated for caspase activation, Bax activation and Bcl-2 down regulation compared to doxorubicin as a standard, and indeed exhibited mainly cell cycle arrest at the Pre-G1 and G2/M phases. The transcription effects of 5a and 5b on the p53 were assessed and compared with the reference doxorubicin. The results revealed an increase of 12-19 in p53 level compared to the test cells and that p53 protein level of 5a and 5b was significantly inductive (991, and 639 pg/mL, resp.) in relation to doxorubicin (1263 pg/mL).

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Product Details of 3326-71-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis, characterization and biological activity of nano-sized Co(II), Ni(II), Cu(II), Pd(II) and Ru(III) complexes of tetradentate hydrazone ligand. Author is Abouzayed, Fatma I.; Emam, Sanaa M.; Abouel-Enein, Saeyda A..

Furo-(phenyldimethine)carbohydrazone (H2L) was prepared via the condensation reaction of 2-furoic acid hydrazide with terephthaldehyde by (2:1) molar ratio. Octahedral and square planar complexes were synthesized from the reaction of (H2L) ligand with chloride salts of Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) ions. All the chelates were structurally characterized by various anal. and spectral techniques. The stoichiometry of chelates was found to be 1:1, 1:2 and 1:3 (L:M) molar ratios to form sandwich, binuclear and trinuclear complexes, resp. All complexes were found to be non-electrolytic in nature on the basis of molar conductance values. The IR data showed that the ligand served as tetradentate in a neutral keto form. The ligand coordinated with all metal ions via oxygen atoms of carbonyl group and furan ring. The thermal properties of the ligand and its chelates were investigated utilizing thermogravimetry and reflected that Ru(III) complex has lower thermal stability than other complexes. X-ray diffraction spectra established nano-size for Ni(II) and Ru(III) complexes. The ESR result revealed axial symmetry with hyperfine structure for Cu(II) complex indicative of (2B1g) as a ground state. Some quantum parameters were reported in order to compare the reactivity of the compounds The biol. data indicated that all complexes have cytotoxic and antioxidant activity rather than the native ligand. Among all complexes, Ru(III) complex had excellent cytotoxic and antioxidant activity. This was due to its chem. structure and its nano-size.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Chalenko, N.; Demchenko, A.; Syrova, G. published the article 《Synthesis of potential antiexudative preparations for 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole-(4h)-3-yl)-sulfanyl)-N-acetamide series》. Keywords: antiexudative antiinflammatory analgesic.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Formula: C5H6N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.

The aim of the study was to synthesize new potential biol. active substances of derivatives of 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole(4H)-3-yl)-sulfanyl)-N acetamides and determination of their structure, physico-chem. properties and anti-exudative activity (AEA). Reactions were started with furan-2-carboxylic acid hydrazide with carbon disulfide in Et alc. in the presence of potassium hydroxide to form potassium dithiocarbazinate intermediate, followed by cyclical condensation with excess hydrazine, yielding tiotriazole (1) as a white solid with a good yield. Twenty-one new compounds were synthesized in the series of derivatives of 2-((4-amino-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl) sulfanyl)-N-acetamides, their phys. and chem. characteristics have been established. The structure of the synthesized compounds is confirmed by data from elemental anal., 1H NMR spectra and chromatog. mass spectrometry. Fifteen compounds have shown antiexudative activity, among the leaders were identified seven compounds: 3.1, 3.2, 3.5, 3.9, 3.11, 3.12, 3.19, which significantly suppressed swelling by 81.5 %; 61.1 %; 70.3 %; 55.5 %; 62.9 %; 53.0 %, resp., and significantly exceeded the activity of sodium diclofenac (44 %).

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of potential antiexudative preparations for 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole-(4h)-3-yl)-sulfanyl)-N-acetamide series, published in 2019-05-31, which mentions a compound: 3326-71-4, mainly applied to antiexudative antiinflammatory analgesic, Electric Literature of C5H6N2O2.

The aim of the study was to synthesize new potential biol. active substances of derivatives of 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole(4H)-3-yl)-sulfanyl)-N acetamides and determination of their structure, physico-chem. properties and anti-exudative activity (AEA). Reactions were started with furan-2-carboxylic acid hydrazide with carbon disulfide in Et alc. in the presence of potassium hydroxide to form potassium dithiocarbazinate intermediate, followed by cyclical condensation with excess hydrazine, yielding tiotriazole (1) as a white solid with a good yield. Twenty-one new compounds were synthesized in the series of derivatives of 2-((4-amino-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl) sulfanyl)-N-acetamides, their phys. and chem. characteristics have been established. The structure of the synthesized compounds is confirmed by data from elemental anal., 1H NMR spectra and chromatog. mass spectrometry. Fifteen compounds have shown antiexudative activity, among the leaders were identified seven compounds: 3.1, 3.2, 3.5, 3.9, 3.11, 3.12, 3.19, which significantly suppressed swelling by 81.5 %; 61.1 %; 70.3 %; 55.5 %; 62.9 %; 53.0 %, resp., and significantly exceeded the activity of sodium diclofenac (44 %).

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Bai, Liping; Xu, Yuhang; Li, Leixuan; Tao, Farong; Wang, Shuangshuang; Wang, Liping; Li, Guang published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).Reference of 2-Furoic hydrazide. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

Furan Schiff base functionalized PEG (PEGFB) was synthesized as an excellent reversible fluorescent chemosensor for the sensitive detection of Al3+ in 100% aqueous solution The non-fluorescent PEGFB displayed high selectivity towards Al3+ over other coexistent metal ions, accompanied by a visual fluorescence change from colorless to bright cyan. The detection limit of PEGFB towards Al3+ was determined to be 7.90 x 10-9 M. PEGFB could be utilized to detect Al3+ in a relatively wide pH range from 5 to 9. The reversible fluorescence response of PEGFB upon the addition of Al3+ and EDTA was successfully used to construct an INHIBIT mol. logic gate. Furthermore, test strips coated with PEGFB could be applied for the convenient and visual sensing of Al3+ in real water samples.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Thummar, Sandeep N.; Bhatt, Vasishta D. researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Synthetic Route of C5H6N2O2.They published the article 《Palladium-catalyzed Suzuki coupling synthesis and biological activities of ten new 1,3,4-oxadiazole derivatives》 about this compound( cas:3326-71-4 ) in Indian Journal of Heterocyclic Chemistry. Keywords: chloroquinolinylthio aryloxadiazole preparation phenylboronic acid Suzuki Coupling; phenylquinolinylthio aryloxadiazole preparation antibacterial antifungal. We’ll tell you more about this compound (cas:3326-71-4).

Ten new 2-phenyl-5-((7-phenylquinolin-4-yl)thio)-1,3,4-oxadiazole derivatives I [R = Ph, 3-pyridyl, 4-methoxyphenyl, etc.] were synthesized and their biol. activities were reported. Dichloroquinoline on sequential reactions with different moieties such as 1,3,4-oxadiazole and phenylboronic acid gave desired target derivatives I with excellent yield. In-vitro antimicrobial activity of the synthesized compounds I was evaluated against Gram-pos. and Gram-neg. bacteria. The synthetic steps involved various bond formations such as C-S and C-C which occurred with the help of nucleophilic substitution reaction. The last synthetic step involved palladium-catalyzed Suzuki coupling reaction to afford C-C bond formation.

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