Category: 3326-71-4

Reference of 2-Furoic hydrazide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Direct Catalytic Symmetrical, Unsymmetrical N,N-Dialkylation and Cyclization of Acylhydrazides Using Alcohols.

Herein, direct N,N-dialkylation of acylhydrazides using alcs. is reported. This catalytic protocol provides one-pot synthesis of both sym. and unsym. N,N-disubstituted acylhydrazides using an assortment of primary and secondary alcs. with remarkable selectivity and excellent yields. Interestingly, the use of diols resulted in intermol. cyclization of acylhydrazides, and such products are privileged structures in biol. active compounds Water is the only byproduct, which makes this catalytic protocol sustainable and environmentally benign.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《ONO pincer palladium (II) complexes featuring furoylhydrazone ligands: Synthesis, characterization and catalytic activity towards Suzuki-Miyaura coupling reaction》. Authors are Qian, Hengyu; Yu, Shuyan; Song, Liping; Zhang, Tongyan; Yin, Zhigang; Zhao, Feng; Yang, Jiale; Wang, Caihong.The article about the compound:2-Furoic hydrazidecas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN).Synthetic Route of C5H6N2O2. Through the article, more information about this compound (cas:3326-71-4) is conveyed.

Four new palladium pincer complexes I (R = H, 3-OMe, 3-OEt, 5-Cl) incorporating ONO type furoylhydrazone ligands have been prepared in good yields. These palladium complexes were structurally characterized by elemental anal., IR, 1H- and 13C-NMR spectra. X-ray single crystal analyses of Pd1-Pd4 revealed that the metal center adopted a slightly distorted square planar geometry in which the hydrazone bound the metal ion via the phenolic-O, azomethine-N and imidolate-O atoms. Using these ONO pincer complexes as catalyst, excellent yields of biaryls could be obtained for coupling of arylboronic acids with aryl bromides at a low catalyst loading (0.01 mol%).

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Design and synthesis of 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives with anti-acetylcholinesterase activities, published in 2021, which mentions a compound: 3326-71-4, mainly applied to diethylaminocoumarinyl oxadiazole preparation acetylcholinesterase inhibition SAR docking; 1,3,4-oxadiazole; Coumarin; acetylcholinesterase inhibitor; molecular docking, COA of Formula: C5H6N2O2.

Twelve novel 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives I [R = n-Bu, 2-thienyl, Ph, etc.] were synthesized via iodine-mediated oxidative cyclization and confirmed by 1H NMR, 13C NMR and HRMS. The synthesized derivatives I were tested against in-vitro acetylcholinesterase inhibitory activity and results showed that compounds I [R = 4-ClC6H4, 4-BrC6H4] exhibited moderate inhibitory activities with 69.19% and 65.06%, resp. The preliminary structure-activity relationships revealed that introduction of halogen atom on the para-position of Ph of compounds I could enhance their activities. Mol. docking study suggested that compound I [R = ClC6H4] possessed an optimal docking pose with interactions inside AChE.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Furoic hydrazide( cas:3326-71-4 ) is researched.Computed Properties of C5H6N2O2.Dige, Nilam C.; Mahajan, Prasad G.; Raza, Hussain; Hassan, Mubashir; Vanjare, Balasaheb D.; Hong, Hansol; Hwan Lee, Ki; Latip, Jalifah; Seo, Sung-Yum published the article 《Ultrasound mediated efficient synthesis of new 4-oxoquinazolin-3(4H)-yl)furan-2-carboxamides as potent tyrosinase inhibitors: Mechanistic approach through chemoinformatics and molecular docking studies》 about this compound( cas:3326-71-4 ) in Bioorganic Chemistry. Keywords: oxoquinazolinyl furancarboxamide green preparation tyrosinase inhibitor chemoinformatic docking antioxidant; isatoic anhydride furoic hydrazide salicylaldehyde acid catalyst ultrasound irradiation; Drug score; Lipinski’s rule; Molecular docking; Oxoquinazolin-3(4H)-yl)furan-2-carboxamides; Tyrosinase; Ultrasound sonication. Let’s learn more about this compound (cas:3326-71-4).

Synthesis of new (4-oxoquinazolin-3(4H)-yl)furan-2-carboxamide derivatives I [R = H, 5-Br, 3-NO2, etc.] via p-TSA catalyzed reaction between isatoic anhydride, 2-furoic hydrazide and substituted salicylaldehydes in ethanol:water (5:5 volume/volume) solvent system under ultrasound irradiation at room temperature was carried out. The important features of this protocol were simple and easy workup procedure, reaction carried out at ambient temperature, use of ultrasound and high yield of (4-oxoquinazolin-3(4H)-yl)furan-2-carboxamides in short reaction time. The synthesized compounds I were screened against tyrosinase enzyme and all these compounds found to be potent inhibitors with much lower IC50 value of 0.028 ± 0.016 to 1.775 ± 0.947 μM than the standard kojic acid (16.832 ± 1.162 μM). The kinetics mechanism for compound I [R = 3,5-di-Br] was analyzed by Lineweaver-Burk plots which revealed that compound inhibited tyrosinase non-competitively by forming an enzyme-inhibitor complex. Along with this all the synthesized compounds I were scanned for their DPPH free radical scavenging ability. The outputs received through in vitro and in silico anal. were coherent to the each other with good binding energy values (kcal/mol) posed by synthesized ligands.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Ke-Hu; Shi, Baobao; Wang, Yalin; Wang, Jianglong; Huang, Danfeng; Su, Yingpeng; Hu, Yulai researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Application of 3326-71-4.They published the article 《Tin-Mediated One-pot Preparation of β-Trifluoromethyl-β-acylhydrazonyl Carbonyl Compounds》 about this compound( cas:3326-71-4 ) in Asian Journal of Organic Chemistry. Keywords: trifluoromethyl acylhydrazonyl carbonyl compound preparation; trifluoroacetaldehyde methyl hemiacetal acylhydrazine bromocarbonyl compound multicomponent reaction. We’ll tell you more about this compound (cas:3326-71-4).

A concise and efficient protocol for the preparation of β-trifluoromethyl-β-acylhydrazonyl carbonyl compounds was developed from multicomponent one-pot reactions of trifluoroacetaldehyde Me hemiacetal, acylhydrazines and 2-bromocarbonyl compounds in the presence of tin powder. The reactions can be carried out under mild reaction conditions to give the products in good to excellent yields.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Furoic hydrazide(SMILESS: O=C(C1=CC=CO1)NN,cas:3326-71-4) is researched.Application of 3326-71-4. The article 《A “”Turn-On”” Fluorescence Probe for Selective Detection of Al3+ in Aqueous Environment: Crystal Structure, Theoretical and Cell Imaging Studies》 in relation to this compound, is published in ChemistrySelect. Let’s take a look at the latest research on this compound (cas:3326-71-4).

A furan-based water soluble fluorescent probe (E)-N′-(2,4-dihydroxybenzylidene)furan-2-carbohydrazide (DBF) has been synthesized and characterized by 1H NMR, 13C NMR, ESI-mass spectroscopy and single crystal X-ray diffraction techniques. The synthesized probe exhibits a “”turn-on”” fluorescence response towards Al3+ in Tris-HCl buffer (10 mM) with no significant interference from other metal ions. The strong fluorescence in the presence of Al3+ is attributed to the CHEF (chelation enhanced fluorescence), inhibition of PET (photo-induced electron transfer) and C=N isomerization. 1 : 1 stoichiometric ratio between DBF and Al3+ was rationalized by Job′s plot. Binding constant and LOD were calculated to be 1.031×105 M-1 and 6.34×10-8 M, resp. MTT assay on live A549 cells indicated no serious cytotoxicity in the cells even at higher concentration Further, DBF was successfully used for the detection of accumulated Al3+ in the cytoplasm of cells.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

SDS of cas: 3326-71-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Palladium-catalyzed Suzuki coupling synthesis and biological activities of ten new 1,3,4-oxadiazole derivatives.

Ten new 2-phenyl-5-((7-phenylquinolin-4-yl)thio)-1,3,4-oxadiazole derivatives I [R = Ph, 3-pyridyl, 4-methoxyphenyl, etc.] were synthesized and their biol. activities were reported. Dichloroquinoline on sequential reactions with different moieties such as 1,3,4-oxadiazole and phenylboronic acid gave desired target derivatives I with excellent yield. In-vitro antimicrobial activity of the synthesized compounds I was evaluated against Gram-pos. and Gram-neg. bacteria. The synthetic steps involved various bond formations such as C-S and C-C which occurred with the help of nucleophilic substitution reaction. The last synthetic step involved palladium-catalyzed Suzuki coupling reaction to afford C-C bond formation.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Category: benzisoxazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis and Antibacterial Activity of Novel (4-Methoxyphenyl)-tetrahydropyranyl-substituted 1,3,4-Oxadiazoles. Author is Aghekyan, A. A.; Mkryan, G. G.; Panosyan, H. A.; Safaryan, A. S.; Stepanyan, H. M..

Condensation of 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonyl chloride I [R1 = Cl] with hydrazine hydrate, furan-2- and 2,5-dimethylfuran-2-carbohydrazides gave disubstituted hydrazides II [R2 = furan-2-carbonyl, (4,5-dimethylfuran-2-carbonyl), 4-(4-methoxyphenyl)tetrahydropyran-4-carbonyl], whose cyclization formed sym. and unsym. 2,5-disubstituted 1,3,4-oxadiazoles III [R3 = 2-furyl, 4,5-dimethyl-2-furyl, 4-(4-methoxyphenyl)tetrahydropyran-4-yl]. Et 4-[4-(4-methoxyphenyl)-tetrahydro-2H-pyran-4-carboxamido]benzoate IV [R4 = CO2Et] was reacted with hydrazine to obtain N-[4-(hydrazinocarbonyl)-phenyl]-4-(4-methoxphenyl)tetrahydro-2H-pyran-4-carboxamide IV [R4 = C(O)NHNH2]. Treatment of IV [R4 = C(O)NHNH2] latter with tri-Et orthoformate gave a monosubstituted 1,3,4-oxadiazole IV [R4 = 1,3,4-oxadiazol-2-yl], and with carbon disulfide, a 5-sulfanyl-1,3,4-oxadiazole derivative IV [R4 = (5-sulfanyl-1,3,4-oxadiazol-2-yl)] was obtained. The subsequent alkylation of this derivative IV [R4 = (5-sulfanyl-1,3,4-oxadiazol-2-yl)] with 5-metoxyfuran-2-Me and benzylaminocarbonylmethyl chlorides substituted chlorides resulted in the synthesis of the corresponding novel S-substituted oxadiazole derivatives V [R5 = 5-methoxycarbonyl-2-furyl, benzylcarbamoyl]. The synthesized compounds I, II, III, IV and V were tested for their antibacterial activity.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Safety of 2-Furoic hydrazide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Phosphine-Free Ruthenium Complex-Catalyzed Synthesis of Mono- or Dialkylated Aryl Hydrazides via the Borrowing Hydrogen Strategy. Author is Joly, Nicolas; Bettoni, Leo; Gaillard, Sylvain; Poater, Albert; Renaud, Jean-Luc.

A diaminocyclopentadienone ruthenium tricarbonyl complex-catalyzed synthesis of mono- or dialkylated aryl hydrazides from N-unsubstituted aryl hydrazides and various substituted primary and secondary alcs. as alkylating reagents using the borrowing hydrogen strategy has been developed. Deuterium labeling experiments confirmed that the alcs. are the hydride source in this cascade process. D. functional theory (DFT) calculations unveiled the origin and the threshold between the mono- and dialkylation.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about BOPAHY: a doubly chelated highly fluorescent pyrrole-acyl hydrazone -BF2 chromophore, the main research direction is dinuclear boron fluoro pyrrole acylhydrazone complex preparation crystal structure; electrochem fluorescence DFT dinuclear boron fluoro pyrrole acylhydrazone complex.COA of Formula: C5H6N2O2.

New easily functionalisable and highly fluorescent BOPAHY chromophores were synthesized via a 1-pot two-step reaction starting from com. available pyrrole-2-carbaldehydes and resp. acyl hydrazides in the presence of BF3·OEt2. Most importantly, all BOPAHY dyes show excellent photophys. properties with quantum yields up to 0.92. Steady-state spectroscopy and quantum chem. calculations provide a first insight into these promising properties.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics