Category: 3326-71-4

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about A KHSO4 mediated facile synthesis of 2-amino-1,3,4-oxadiazole derivatives, the main research direction is amino oxadiazole preparation; isothiocyanate hydrazide potassium catalyst intramol cyclization desulfurization green chem.Quality Control of 2-Furoic hydrazide.

A novel, efficient and mild KHSO4 mediated synthesis for 2-amino-1,3,4-oxadiazoles were established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate derivatives in one pot. The reactions proceeded smoothly at room temperature and produced corresponding products in moderate to good yields. This protocol also showed good functional group tolerance.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Iodine-promoted one-pot synthesis of 1,3,4-oxadiazole scaffolds via sp3 C-H functionalization of azaarenes.Recommanded Product: 2-Furoic hydrazide.

An efficient iodine-mediated one-pot synthetic protocol for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles scaffolds I [R = 2-furyl, Ph, 4-ClC6H4, etc.; R1 = 2-pyridyl, 2-quinolinyl, 7-Clquinolin-2-yl, etc.] was developed via sp3 C-H functionalization. This method involved oxidative amination with concomitant base-mediated cyclization of methylhetarenes and acylhydrazines by employing iodine and Cs2CO3. The key features of the present method included good functional group tolerance, a clean protocol, metal-free conditions and high yields, making this protocol an attractive strategy toward the synthesis of bioactive mols. and their key building blocks.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

SDS of cas: 3326-71-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Catalytic oxidation of benzyl-alcohol with H2O2 in the presence of a dioxidomolybdenum(VI) complex. Author is Balapoor, Leila; Bikas, Rahman; Dargahi, Maryam.

A new dioxidomolybdenum(VI) complex, [MoO2(L)(CH3OH)] (1), was synthesized by the reaction of MoO3 with ONO-donor hydrazone ligand that was obtained from the condensation of benzolyacetone and furan-2-carbohydrazide in methanol. Both of the ligand and complex were characterized by elemental anal. and FTIR, NMR and UV-visible spectroscopic methods. The structure of complex was also determined by single crystal x-ray anal. Structural anal. showed that the Mo(VI) ion has a distorted octahedral geometry and the ligand is coordinated to the metal ion as dineg. ONO-donor ligand. The obtained molybdenum(VI) complex was used as catalyst in oxidation of benzyl alc. with H2O2 as a green oxidant. The effects of some parameters such as temperature, solvent and ratio of materials were also studied. Catalytic studies indicated that complex 1 can efficiently catalyze the oxidation of benzyl alc. but its activity and selectivity are considerably dependent on the reaction condition.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Spatial structure, thermodynamics and kinetics of formation of hydrazones derived from pyridoxal 5′-phosphate and 2-furoic, thiophene-2-carboxylic hydrazides in solution, published in 2019-06-01, which mentions a compound: 3326-71-4, Name is 2-Furoic hydrazide, Molecular C5H6N2O2, Application of 3326-71-4.

The spatial structure of pyridoxal 5′-phosphate hydrazones of 2-furoic hydrazide; thiophene-2-carboxylic hydrazide in aqueous solution was studied by means of quantum chem. calculations and NOE experiment The hydrazones could exist as a mixture of different conformers; however, the specific ones could be suggested from exptl. and calculated data. The stability constants of hydrazones at pH of 1.9; 6.6; 7.0; 7.4 were determined using UV-Vis spectroscopy. Rate constants of the hydrazone formation and hydrolysis reaction within the range of 6.6-7.4 pH were obtained. Isothermal calorimetric titration was performed in order to determine the change in the free Gibbs energy, enthalpy and entropy of hydrazones formation at pH of 6.6. Hydrazones were synthesized and characterized by means of 1H, 13C, 31P NMR, IR, UV-Vis, fluorescent, MS-spectroscopy as well as DSC and elemental anal.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Related Products of 3326-71-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis of New Cyanopyridine Scaffolds and their Biological Activities.

The 3-cyanopyridine analogs I, II and III [Ar = 4-methylphenyl, 4-methoxyphenyl, 4-chlorophenyl, etc.] were synthesized and examined to determine their activity against the M. tuberculosis H37Rv strain. Derivatives I [2-thienyl, 4-chlorophenyl] and II [Ar = 2-furyl, 2-thienyl]had good inhibition. Further screening was done for the highest potency against M. tuberculosis to determine the MICs. The antioxidant efficacy was evaluated via the DPPH technique matched with vitamin C as a pos. control. Some synthesized derivatives displayed good potency against bacterial activity and M tuberculosis. The antioxidant performance of these derivatives did not display scavenging efficacies compared to vitamin C. The cytotoxic activity of the synthesized derivatives was also examined various cell lines to display good cytotoxic activity in the order III > II > I.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about Tin-Mediated One-pot Preparation of β-Trifluoromethyl-β-acylhydrazonyl Carbonyl Compounds, the main research direction is trifluoromethyl acylhydrazonyl carbonyl compound preparation; trifluoroacetaldehyde methyl hemiacetal acylhydrazine bromocarbonyl compound multicomponent reaction.Electric Literature of C5H6N2O2.

A concise and efficient protocol for the preparation of β-trifluoromethyl-β-acylhydrazonyl carbonyl compounds was developed from multicomponent one-pot reactions of trifluoroacetaldehyde Me hemiacetal, acylhydrazines and 2-bromocarbonyl compounds in the presence of tin powder. The reactions can be carried out under mild reaction conditions to give the products in good to excellent yields.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Furoic hydrazide(SMILESS: O=C(C1=CC=CO1)NN,cas:3326-71-4) is researched.Synthetic Route of C18H20N2O12. The article 《Synthesis, crystal structures, and characterization of three zinc complexs with different acylhydrazone-type schiff base ligands》 in relation to this compound, is published in Wuji Huaxue Xuebao. Let’s take a look at the latest research on this compound (cas:3326-71-4).

Three zinc complexes, namely [Zn(Lss)(phen)(DMF)] (1), {[Zn (HLdis)]2·2CH3OH}n (2) and [Zn(Baf)2]·CH3OH (3), formed from different acylhydrazone-type Schiff base ligands were synthesized by using different methods, and the compounds were characterized by IR, UV-Vis spectra and TGA. The X-ray diffraction analyses revealed that 1 and 3 crystallized in the triclinic space group P1̅ while 2 in monoclinic system space group P21/n. In 1 and 3, coordination number of the Zn (II) was six, and the centric atom located in a distorted octahedron geometry, while in 2 Zn (II) was five-coordination in a distorted square-pyramidal geometry. The precursor of 3 was pyrazoline derivative with the formula C15H14N2O3 (Pzl) crystallizing in monoclinic system space group P21/c. Due to the coordination of Zn (II) causing the intramol. rearrangement of Pzl, the ring open product HBaf in the form of an acylhydrazone structure coordinated with Zn (II) to form complex 3.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Safety of 2-Furoic hydrazide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis, characterization, crystal structure, Hirshfeld surface analysis and DFT calculations of two novel pyrrole derivatives. Author is Chethan Prathap, K. N.; Shalini, P.; Lokanath, N. K..

The novel pyrroles (E)-N’-(1-(1H-pyrrol-2-yl)ethylidene)benzenesulfonohydrazide and (E)-N’-(1-(1H-pyrrol-2-yl)ethylidene)furan-2-carbohydrazide were synthesized. The synthesized comps. were characterized by (1H and 13C) NMR, FT-IR, UV-visible, TG-DTA and XRD studies.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Quality Control of 2-Furoic hydrazide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Water-Soluble Dioxidovanadium(V) Complexes of Aroylhydrazones: DNA/BSA Interactions, Hydrophobicity, and Cell-Selective Anticancer Potential. Author is Sahu, Gurunath; Banerjee, Atanu; Samanta, Rajib; Mohanty, Monalisa; Lima, Sudhir; Tiekink, Edward R. T.; Dinda, Rupam.

Five new anionic aqueous dioxidovanadium(V) complexes, [{VO2L1,2}A(H2O)n]α (1-5), with the aroylhydrazone ligands pyridine-4-carboxylic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide (H2L1) and furan-2-carboxylic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide (H2L2) incorporating different alkali metals (A = Na+, K+, Cs+) as countercation were synthesized and characterized by various physicochem. techniques. The solution-phase stabilities of 1-5 were determined by time-dependent NMR and UV-visible, and also the octanol/water partition coefficients were obtained by spectroscopic techniques. X-ray crystallog. of 2-4 confirmed the presence of vanadium(V) centers coordinated by two cis-oxido-O atoms and the O, N, and O atoms of a dianionic tridentate ligand. To evaluate the biol. behavior, all complexes were screened for their DNA/protein binding propensity through spectroscopic experiments Finally, a cytotoxicity study of 1-5 was performed against colon (HT-29), breast (MCF-7), and cervical (HeLa) cancer cell lines and a noncancerous NIH-3T3 cell line. The cytotoxicity was cell-selective, being more active against HT-29 than against other cells. In addition, the role of hydrophobicity in the cytotoxicity was explained in that an optimal hydrophobicity is essential for high cytotoxicity. Moreover, the results of wound-healing assays indicated antimigration in case of HT-29 cells. Remarkably, 1 with an IC50 value of 5.42 ± 0.15μM showed greater activity in comparison to cisplatin against the HT-29 cell line.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Electric Literature of C5H6N2O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Facile synthesis of 1,3,4-oxadiazoles via iodine promoted oxidative annulation of methyl-azaheteroarenes and hydrazides.

An oxidative sp3 C-H bond of methyl-azaheteroarenes protocol RCH3 (R = quinolin-2-yl, benzo[f]quinolin-3-yl, pyridin-2-yl, etc.) was reported for the synthesis of 1,3,4-oxadiazoles I (R1 = 2H-1,3-benzodioxol-5-yl, furan-2-yl, prop-1-en-2-yl, etc.) via [4+1] annulation with hydrazides R1C(O)NHNH2. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles I via selective oxidation of sp3 C-H bond of methyl-azaheteroarenes in the presence of I2-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics