Category: Benzisoxazole

Recommanded Product: 2-Furoic hydrazide. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Crystal structure of N′-[4-(dimethylamino)benzylidene]furan-2-carbohydrazide monohydrate. Author is Sylla-Gueye, Rokhaya; Thiam, Ibrahima Elhadji; Orton, James; Coles, Simon; Gaye, Mohamed.

The condensation of 2-furoic hydrazide and 4-dimethyl aminobenzaldehyde in ethanol yielded a yellow solid formulated as the title compound, C14H15N3O2·H2O. The crystal packing is stabilized by intermol. O(water)-H···O,N(carbohydrazide) and N-H···O(water) hydrogen bonds, which form a two-dimensional network along the bc plane. Addnl. C-H···O interactions link the mols. into a three-dimensional network. The dihedral angle between the mean planes of the benzene and the furan ring is 34.47 (6)°. The carbohydrazide moiety, i.e., the C=N-N-C=O fragment and the benzene ring are almost coplanar, with an angle of 6.75 (9)° between their mean planes.

After consulting a lot of data, we found that this compound(3326-71-4)Recommanded Product: 2-Furoic hydrazide can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Recommanded Product: 610-09-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Probing molecular structure by the chemical resolution of hydrogen migrations. Author is Keough, T..

MeCl chem.-ionization mass spectroscopy, involving a methylation technique based on the chem. resolution of H migrations, gives ionic fragments which differentiate cis and trans isomers. The method differentiates 1,2-cyclohexanedicarboxylic acids but fails (as do protonation methods) to differentiate 1,2-cyclohexanediols. The utility of methylation in conjunction with mass spectra/mass spectra techniques in distinguishing the regioisomerism of HOC6H4CO2H is discussed.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Recommanded Product: 610-09-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about 3,8-Thionanedione 1,1-dioxide. Synthesis and solid-state conformation. Author is Quin, Louis D.; Leimert, John; Middlemas, Eric D.; Miller, Richard W.; McPhail, Andrew T..

The title compound is conventiently prepared in 80% overall yield by ozonolysis at -78°C of the cycloadduct of SO2 with 1,2-dimethylenecyclohexane. Single-crystal X-ray anal. establishes that the nine-membered ring adopts a twist-chair-chair conformation in which the S and the mid-point of the C(5)-C(6) bond lie on a noncrystallog. C2 axis, but the ring shape differs significantly from that of cyclononane in order to accommodate transannular dipole…dipole interactions.

After consulting a lot of data, we found that this compound(610-09-3)Recommanded Product: 610-09-3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Methyl 2,4-dichloronicotinate, is researched, Molecular C7H5Cl2NO2, CAS is 442903-28-8, about Long-lived states to sustain SABRE hyperpolarised magnetisation.Quality Control of Methyl 2,4-dichloronicotinate.

The applicability of the magnetic resonance (MR) technique in the liquid phase is limited by poor sensitivity and short nuclear spin coherence times which are insufficient for many potential applications. Here the authors illustrate how it is possible to address both of these issues simultaneously by harnessing long-lived hyperpolarized spin states that are formed by adapting the Signal Amplification by Reversible Exchange (SABRE) technique. The authors achieve >4% net 1H-polarization in a long-lived form that remains detectable for over ninety seconds by reference to proton pairs in the biol. important mol. nicotinamide and a pyrazine derivative whose in vivo imaging will offer a new route to probe disease in the future.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about A novel turn on fluorescent probe for the determination of Al3+ and Zn2+ ions and its cells applications.Application In Synthesis of 2-Furoic hydrazide.

Early detection of probes is very important for limiting toxic effects of various transition metal ions for example aluminum and zinc. Monitoring of these metal ions can be challenging via conventional methods since they are high cost instrumentations, time consuming and so on. The authors report facile preparation of a fluorescence probe containing biphenyl groups that effectively selective and superb sensitivity towards aluminum(III) and zinc(II) in neutral solutions without interference from each other and other ions. In neutral pH value, the probe FOB displayed the OFF-ON fluorescence enhancement at 464 nm and 512 nm toward aluminum(III) and zinc(II), resp. The detection limit values of FOB for Al3+ and Zn2+ in neutral solutions were 1.27 and 1.02 nM, resp. and these values were significantly lower than permitted Al3+ and Zn2+ concentrations in drinking water determined by the World Health Organization (WHO) and European Water Quality. Also, fabricated cyano-biphenyl based probe is effective for sensing for aluminum(III) and zinc(II) in living human colon cancer cells even when employed at low concentrations (1.0μM). Overall, this work allows the authors to obtain a great potential to be applied to detect Al3+ and Zn2+.

After consulting a lot of data, we found that this compound(3326-71-4)Application In Synthesis of 2-Furoic hydrazide can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Name: cis-Cyclohexane-1,2-dicarboxylic acid. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Construction of coordination frameworks based on 4-imidazolyl tecton 1,4-di(1H-imidazol-4-yl)benzene and varied carboxylic acids. Author is Chen, Shui-Sheng; Zhao, Yue; Fan, Jian; Okamura, Taka-aki; Bai, Zheng-Shuai; Chen, Zhi-Hao; Sun, Wei-Yin.

Nine new coordination polymers [Mn(L)(OX)] (1), [Zn(L)(MBDC)] (2), [Zn(L)(BPDA)] (3), [Co3(L)2(BTA)2]·2H2O (4), [Co2(L)2(BTCA)]·2H2O (5), [Ni(L)(e,a-cis-1,2-CHDC)]·2H2O (6), [Co(L)(e,a-cis-1,4-CHDC)] (7), [Co(L)(e,e-trans-1,4-CHDC)]·2H2O (8) and [Co(L)(e,e,e-cis-1,3,5-HCHTC)]·0.45H2O (9) were obtained by reactions of varied metal salts with 1,4-di(1H-imidazol-4-yl)benzene (L) in the presence of corresponding auxiliary ligands of oxalic acid (H2OX), 5-methyl-1,3-benzenedicarboxylic acid (H2MBDC), 4,4′-biphenyldicarboxylic acid (H2BPDA), benzene-1,3,5-triacetic acid (H3BTA), 1,2,4,5-benzenetetracarboxylic acid (H4BTCA), cis-1,2-cyclohexanedicarboxylic acid (cis-1,2-H2CHDC), cis-/trans-1,4-cyclohexanedicarboxylic acid (cis-/trans-1,4-H2CHDC) and cis-1,3,5-cyclohexane tricarboxylic acid (cis-1,3,5-H3CHTC), resp. Complex 1 has a one-dimensional (1D) chain structure and 2 has a two-dimensional (2D) network with 63-hcb topol. Complex 3 is a complicated uninodal 4-connected three-dimensional (3D) net with Point (Schlaefli) symbol (4.6.83·10)(4.63·82)(63·103)(64·82) while 4 is a (3,8)-connected tfz-d 3D net with Point (Schlaefli) symbol (43)2(46·618·84) based on the trinuclear Co(II) secondary building units (SBUs). Complex 5 is a 3-fold interpenetrating mog net with Point (Schlaefli) symbol of (4.64·8)2(42·62·82), while 6 is a 2D net with (4,4) topol. based on binuclear SBUs. In contrast to the 2D network of 7 with e,a-cis-1,4-CHDC2-, 8 with e,e-trans-1,4-CHDC2- is a 5-fold interpenetrating 66-dia 3D net. Complex 9 has a 1D ladder-like chain structure with a stable conformation from the e,e,e-cis-1,3,5-HCHTC2- ligand. Complexes 2 and 3 exhibit intense light blue emission in the solid state at room temperature and the results of magnetic measurements showed that there are antiferromagnetic interactions in 1.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Furoic hydrazide(SMILESS: O=C(C1=CC=CO1)NN,cas:3326-71-4) is researched.Application In Synthesis of 2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine. The article 《Tin-Mediated One-pot Preparation of β-Trifluoromethyl-β-acylhydrazonyl Carbonyl Compounds》 in relation to this compound, is published in Asian Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:3326-71-4).

A concise and efficient protocol for the preparation of β-trifluoromethyl-β-acylhydrazonyl carbonyl compounds was developed from multicomponent one-pot reactions of trifluoroacetaldehyde Me hemiacetal, acylhydrazines and 2-bromocarbonyl compounds in the presence of tin powder. The reactions can be carried out under mild reaction conditions to give the products in good to excellent yields.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Love, Dillon; Kim, Kangmin; Domaille, Dylan W.; Williams, Olivia; Stansbury, Jeffrey; Musgrave, Charles; Bowman, Christopher published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).COA of Formula: C5H6N2O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

Despite the powerful nature of the aza-Michael reaction for generating C-N linkages and bioactive moieties, the bis-Michael addition of 1° amines remains ineffective for the synthesis of functional, step-growth polymers due to the drastic reduction in reactivity of the resulting 2° amine mono-addition adduct. In this study, a wide range of com. hydrazides are shown to effectively undergo the bis-Michael reaction with divinyl sulfone (DVS) and 1,6-hexanediol diacrylate (HDA) under catalyst-free, thermal conditions to afford moderate to high mol. weight polymers with Mn = 3.8-34.5 kg mol-1. The hydrazide-Michael reactions exhibit two distinctive, conversion-dependent kinetic regimes that are 2nd-order overall, in contrast to the 3rd-order nature of amines previously reported. The mono-addition rate constant was found to be 37-fold greater than that of the bis-addition at 80°C for the reaction between benzhydrazide and DVS. A significant majority (12 of 15) of the hydrazide derivatives used here show excellent bis-Michael reactivity and achieve >97% conversions after 5 days. This behavior is consistent with calculations that show minimal variance of electron d. on the N-nucleophile among the derivatives studied. Reactivity differences between hydrazides and hexylamine are also explored. Overall, the difference in reactivity between hydrazides and amines is attributed to the adjacent nitrogen atom in hydrazides that acts as an efficient hydrogen-bond donor that facilitates intramol. proton-transfer following the formation of the zwitterion intermediate. This effect not only activates the Michael acceptor but also coordinates with addnl. Michael acceptors to form an intermol. reactant complex.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Related Products of 37443-42-8. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Molecular features of the prazosin molecule required for activation of Transport-P. Author is Mendes da Silva, Joaquim Fernando; Walters, Marcus; Al-Damluji, Saad; Ganellin, C. Robin.

Closely related structural analogs of prazosin have been synthesized and tested for inhibition and activation of Transport-P in order to identify the structural features of the prazosin mol. that appear to be necessary for activation of Transport-P. So far, all the compounds tested are less active than prazosin. It is shown that the structure of prazosin appears to be very specific for the activation. Only quinazolines have been found to activate, and the presence of the 6,7-dimethoxy and 4-amino groups appears to be critically important.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Safety of 2-Furoic hydrazide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis, structural characterization, and computational study of (E)-N’-(3,4-dimethoxybenzylidene)furan-2-carbohydrazide. Author is Mkadmh, Ahmed M.; Morjan, Rami Y.; Raftery, James; Awadallah, Adel M.; Gardiner, John M..

An efficient synthesis of the new (E)-N’-(3,4-dimethoxybenzylidene)furan-2-carbohydrazide is described. Its mol. structural features have been characterized by single crystal X-ray diffraction. Quantum chem. calculations including mol. geometry, intermol. H-bonds and vibrational frequencies were carried out for the structures to explain stability and geometry using the hybrid d. functional (DFT/B3LYP) in conjunction with 6-311 + G(d,p) basis set. The calculated structural and vibrational parameters are presented and compared with their exptl. X-ray and FTIR counterparts. The global min. and local min. ground states characteristics of the title compound and its rotamers have been theor. established through 2D potential energy scan and vibrational frequencies. Computational anal. predicted that head-to-tail E/E-dimer of the observed E-isomer has significantly stronger intermol. hydrogen bonding in solution rather than in the gaseous state. It is found that N-H and C=O vibrational bands suffering blue-shift due to intermol. hydrogen bonds (IHBs). Weak intramol. hydrogen bonds that have been detected in the monomeric form in the gaseous state and in solution are lacking in trimers and tetramers due to loss of planarity in the mol. structure. Optimization in solution clearly shows that the strength of the IHBs decreased exponentially with dielec. continuum of the solvent used. Inexistence of solvent/monomer intermol. hydrogen bonds has been explained in terms of Condensed Fukui Functions.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics