Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Platinum(II) and palladium(II) complexes analogous to oxaliplatin with different cyclohexyldicarboxylate isomeric anions and their in vitro antitumour activity. Structural elucidation of [Pt(C2O4)(cis-dach)].Product Details of 610-09-3.
Several new PtII and PdII complexes bearing the enantiomerically pure (1R,2R)-(-)-1,2-cyclohexanediamine (dach) ligand, [MX2{(1R,2R)-dach}], where M = Pt or Pd, X2 = cis- or trans- or (1R,2R)-1,2-cyclohexyldicarboxylate anions, were synthesized and characterized physicochem. and spectroscopically. These complexes were screened in vitro against the three tumor cell lines K562, HeLa and L929, and the results obtained were compared with those of the reference standards, cisplatin, carboplatin and oxaliplatin; the known antitumor drugs. The single crystal x-ray structure determination of the [Pt(C2O4)(cis-dach)] complex is discussed and compared with that of oxaliplatin, [Pt(C2O4){(1R,2R)-dach}].
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics