Extracurricular laboratory: Discover of 5-Chloro-3-phenylbenzo[c]isoxazole

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New Advances in Chemical Research in 2021. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. 719-64-2, Name is 5-Chloro-3-phenylbenzo[c]isoxazole, SMILES is ClC1=CC2=C(C3=CC=CC=C3)ON=C2C=C1, in an article , author is Jadhav, VK, once mentioned of 719-64-2, Product Details of 719-64-2.

An efficient and convenient methodology has been developed for the conversion of 2-hydroxy phenyl ketoxime to 1,2-benzisoxazole 2-oxide with sodium perborate (SPB) in glacial acetic acid under mild reaction conditions. Interestingly when the reaction was carried out under reflux condition deoximation was observed in quantitative yield.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics