So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Thummar, Sandeep N.; Bhatt, Vasishta D. researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Synthetic Route of C5H6N2O2.They published the article 《Palladium-catalyzed Suzuki coupling synthesis and biological activities of ten new 1,3,4-oxadiazole derivatives》 about this compound( cas:3326-71-4 ) in Indian Journal of Heterocyclic Chemistry. Keywords: chloroquinolinylthio aryloxadiazole preparation phenylboronic acid Suzuki Coupling; phenylquinolinylthio aryloxadiazole preparation antibacterial antifungal. We’ll tell you more about this compound (cas:3326-71-4).
Ten new 2-phenyl-5-((7-phenylquinolin-4-yl)thio)-1,3,4-oxadiazole derivatives I [R = Ph, 3-pyridyl, 4-methoxyphenyl, etc.] were synthesized and their biol. activities were reported. Dichloroquinoline on sequential reactions with different moieties such as 1,3,4-oxadiazole and phenylboronic acid gave desired target derivatives I with excellent yield. In-vitro antimicrobial activity of the synthesized compounds I was evaluated against Gram-pos. and Gram-neg. bacteria. The synthetic steps involved various bond formations such as C-S and C-C which occurred with the help of nucleophilic substitution reaction. The last synthetic step involved palladium-catalyzed Suzuki coupling reaction to afford C-C bond formation.
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics