Heterocyclic Building Blocks-Benzisoxazole

Quality Control of 2-Furoic hydrazide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthetic stratagem, characterization and biocidal applications of triorganotin(IV) complexes derived from hydrazide/hydrazone analogues. Author is Mehmood, Mehwish; Imtiaz-ud-Din; Nawaz Tahir, Muhammad; Haq, Ihsan-ul; Zahra, Syeda Saniya.

A series of Schiff base ligands as benzylidene benzohydrazide and their hydrazone analogs (Ia-Ic) have been synthesized and then complexed with organotin(IV) moiety having general formula [R’3SnL] to get the target compounds (1-9), where L = C4H3OCONHN:CHR, R = C6H5O (Ia), C4H5O (Ib), C6H3Cl2 (Ic) and R’ = -CH3 (1-3), -CH2Ph (4-6), -Ph (7-9). They were fully characterized using FT-IR, NMR (1H, 13C and 119Sn) spectroscopy, along with elemental anal. and m.p. One of the precursor (Ib) has been analyzed by single crystal XRD to further authenticate the structure. The 119Sn NMR data suggest the mol. geometry of organotin derivatives as distorted pentagonal bipyramidal. They were also evaluated for their antibacterial, antifungal, α-amylase inhibition, DPPH, total reducing power and total antioxidant activities. Triaryltin(IV) derivatives show good antibacterial and antifungal activity. Whereas the data for antidiabetic activity demonstrated that the compounds may serve as moderately effective alpha amylase inhibitor.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called In vitro evaluations of biomolecular interactions, antioxidant and anticancer activities of Nickel(II) and Copper(II) complexes with 1:2 coordination of anthracenyl hydrazone ligands, published in 2021-09-01, which mentions a compound: 3326-71-4, Name is 2-Furoic hydrazide, Molecular C5H6N2O2, Product Details of 3326-71-4.

A set of nickel(II) and copper(II) complexes incorporated anthracenyl hydrazone ligands were synthesized and characterized with the help of various spectroscopic techniques. Single-crystal XRD studies revealed that all four complexes have square planar geometry in which the hydrazones are coordinated through NO atoms with 1:2 metal to ligand stoichiometry. Bio-mol. interactions of these complexes were analyzed using UV and emission spectroscopic studies, which revealed that compounds interact with calf thymus DNA (CT-DNA) through intercalation and also bind strongly with BSA. This further has been confirmed by theor. studies. Anticancer nature of the compounds was evaluated with the help of MTT assay against colon cancer cells (HCT-15) and normal skin cells (L929). It is verified that the complexes showed excellent cytotoxicity to cancer cells whereas negligible toxicity towards normal cells. Antioxidant activity was checked by DPPH radical scavenging assay and found that the complexes are capable of reducing available radicals. The complexes initiated cell death via reactive oxygen species generation was determined by ROS assay. The morphol. transformations observed in cell lines treated with different concentrations of complexes have been observed with the help of SEM (SEM). Flow cytometric anal. expressed that the synthesized complexes can induce apoptotic cell death, hence eligible for further studies.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Altun, Ozlen; Turkyilmaz, Murat; Husyinova, Gulara; Cerkezkayabekir, Aysegul; Feyizoglu, Adilhan researched the compound: cis-Cyclohexane-1,2-dicarboxylic acid( cas:610-09-3 ).Application of 610-09-3.They published the article 《Synthesis and properties of some basic metals and manganese salts of cis-1,2-cyclohexane dicarboxylic acid》 about this compound( cas:610-09-3 ) in Asian Journal of Chemistry. Keywords: transition metal cyclohexanedicarboxylate preparation; wheat fertilizer liver inhibition transition metal cyclohexanedicarboxylate. We’ll tell you more about this compound (cas:610-09-3).

Sodium, potassium, ammonium and manganese salts of cis-1,2-cyclohexanedicarboxylic acid were synthesized. The structural characteristics of these salts were analyzed by thermog. and spectroscopic methods and examined on liver and wheat under the effect of their biol. activities. They can be used as a micro-fertilizer in the fields biol. and agriculture.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Photoreduction of carbon dioxide to its radical anion by nickel cluster [Ni3(μ3-I)2(dppm)3]: formation of two carbon-carbon bonds via addition of carbon dioxide radical anion to cyclohexene.Product Details of 610-09-3.

The trinuclear cluster Ni3(μ3-I)2(dppm)3, (1) [dppm = bis(diphenylphosphino)methane] is formed by conproportionation of Ni(COD)2 and NiI2 in the presence of dppm. Cluster 1 and its singly oxidized radical cation (2) have been characterized spectroscopically and by x-ray diffraction. Cluster 2 exhibits a slight Jahn-Teller distortion of its triangular nickel framework. Irradiation of 1 in the presence of CO2 results in photochem. electron transfer to produce CO2•- and 2. The CO2•- can be trapped by H-atom abstraction from toluene to produce formate ion or with cyclohexene to form cis- and trans-1,2-cyclohexanedicarboxylic acid. The radical anion disproportionation products, carbonate and CO, are observed in the absence of a trapping reagent for CO2•-.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Quality Control of cis-Cyclohexane-1,2-dicarboxylic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Analysis of the stereochemistry of cyclic dicarboxylic acids by potentiometric titration. IX. Acidic ionization of stereoisomeric cyclic 1,2-dicarboxylic acids in aqueous methanol mixtures. Author is Salakhov, M. S.; Israfilov, A. I.; Gulieva, R. S.; Mamedov, S. A..

The ionization constants of I-V were determined at 25° for potentiometric titration The cis acids were weaker than the trans acids, and the saturated acids were weaker than the unsaturated ones. The distance between ionizing carboxyls in cis-trans pairs, as calculated by the Ingold method, was apparently the same.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Furoic hydrazide(SMILESS: O=C(C1=CC=CO1)NN,cas:3326-71-4) is researched.Safety of Palladium(II) acetate. The article 《Design and synthesis of new pyranoquinolinone heteroannulated to triazolopyrimidine of potential apoptotic antiproliferative activity》 in relation to this compound, is published in Bioorganic Chemistry. Let’s take a look at the latest research on this compound (cas:3326-71-4).

Pyrano[3,2-c]quinoline derivatives have been synthesized and utilized to obtain various new hetero-annulated triazolopyrimidine, containing quinoline, pyran, 1,2,4-triazine and pyrimidine in good yields. Newly synthesized compounds have been characterized by spectral data and elemental anal. Most of the synthesized compounds showed moderate to weak antiproliferative activity on most cancer cell lines, especially leukemia and breast cancer cell lines. The open chain formimidic acid Et ester is slightly more potent than hetero-annulated systems. The most active compounds were further investigated for caspase activation, Bax activation and Bcl-2 down regulation compared to doxorubicin as a standard, and indeed exhibited mainly cell cycle arrest at the Pre-G1 and G2/M phases. The transcription effects of 5a and 5b on the p53 were assessed and compared with the reference doxorubicin. The results revealed an increase of 12-19 in p53 level compared to the test cells and that p53 protein level of 5a and 5b was significantly inductive (991, and 639 pg/mL, resp.) in relation to doxorubicin (1263 pg/mL).

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Sharma, Mukesh; Das, Biraj; Sarmah, Jugal Charan; Hazarika, Anil; Deka, Biplab K.; Park, Young-Bin; Bania, Kusum K. researched the compound: cis-Cyclohexane-1,2-dicarboxylic acid( cas:610-09-3 ).Recommanded Product: cis-Cyclohexane-1,2-dicarboxylic acid.They published the article 《Fractal to monolayer growth of AgCl and Ag/AgCl nanoparticles on vanadium oxides (VOx) for visible-light photocatalysis》 about this compound( cas:610-09-3 ) in Journal of Materials Chemistry A: Materials for Energy and Sustainability. Keywords: fractal growth halide silver nanoparticle dope vanadium oxide v; visible light photocatalysis. We’ll tell you more about this compound (cas:610-09-3).

A facile and simple methodol. was adopted for the trapping of highly crystalline AgCl and Ag/AgCl nanoparticles (NPs) into the interlayer spacings of vanadium oxides (VOx). Self-organization of AgCl and Ag/AgCl-NPs on VOx was found to be governed by the nature of the dicarboxylic acids used during the synthesis of the nanocomposites. A “”fractals-like”” morphol. of the AgCl@VOx nanocomposite was achieved in the presence of cis-1,2 cyclohexanedicarboxylic acid. Heating of the AgCl@VOx nanocomposite above 68 °C resulted in the growth of polydispersed and ultrafine (3-4 nm) Ag/AgCl-NPs and its self-organization into monolayer formation on a partly crystalline VOx matrix. Change in the conformation of the dicarboxylic acid to the trans-isomer resulted in the formation of a ‘rod-like’ structure of Ag/AgCl-NPs on a highly crystalline VOx matrix. The band gaps of the nanocomposites were within the range of 1.8 to 2.9 eV. Because of such a low band gap, the synthesized nanocomposites were found to be highly active toward the photooxidation of methylene (MB) and methyl orange (MO) under sunlight.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 37443-42-8, is researched, SMILESS is O=C(C1OCCC1)OC, Molecular C6H10O3Journal, Article, Lipids called Antitumor activity of SRI 62-834, a cyclic ether analog of ET-18-OCH3, Author is Houlihan, William J.; Lee, Mark L.; Munder, Paul G.; Nemecek, Georgina M.; Handley, Dean A.; Winslow, Christine M.; Happy, John; Jaeggi, Christian, the main research direction is SRI 62834 preparation antitumor; blood platelet aggregation inhibitor SRI 62834; tatrahydrofuran ether phospholipid analog preparation antitumor.Related Products of 37443-42-8.

SRI 62-834 (I), an analog of the antitumor agent ET-18-OCH3 in which the O atom at C atom 2 was incorporated into a 5-membered heterocycle, was prepared and exhibited good cytotoxicity in vitro against a variety of tumor cell lines and was as effective as Et-18-OCH3 given orally to mice with Meth A sarcomas. SRI 62-834 inhibited platelet-derived growth factor, possibly at the receptor level, and platelet-activating factor at the receptor level.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Shinozaki, Kohichi; Abe, Mitsuyuki; Uchiyama, Midori published an article about the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8,SMILESS:O=C(C1OCCC1)OC ).HPLC of Formula: 37443-42-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:37443-42-8) through the article.

Hydrogenation of I in R1OH (R1 = lower alkyl) in the presence of Pd black or PdO was studied. I (R = H, Me) over Pd black formed small amounts of intermediate by-product ketals (II), which were hydrogenolyzed to the main products (III). With PdO, considerable amounts of II were formed from I (R = H, Me, CH:CHCO2Me, CO2Me). The amount of II formed decreased with increasing size of both R and R1.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, antioxidant and antitumor activities of some of new cyclobutane containing triazoles derivatives, published in 2019, which mentions a compound: 3326-71-4, Name is 2-Furoic hydrazide, Molecular C5H6N2O2, Formula: C5H6N2O2.

Thiosemicarbazides were obtained by the interaction of furan-2-carboxylic acid hydrazide with five different isothiocyanate (RNCS) derivatives By addition of KOH to the reaction medium, 1,2,4-triazoles derivatives I [R = Et, allyl, Ph, benzyl, 4-MeC6H4] were obtained. Compounds I were dissolved in dry acetone containing K2CO3 in the presence of 2-chloro-1-(3-methyl-3-mesitylcyclobutyl)ethanone to give 3,4,5-trisubstituted 1,2,4-triazole sulfanyl compounds II. The structures of the final compounds were confirmed by elemental analyses, FT-IR, 1H-NMR and 13C-NMR. The antioxidant and antitumor properties of the synthesized compounds were also investigated. Three of the triazole derivatives II [R = Ph, benzyl, 4-MeC6H4] displayed good antioxidant and antitumor activity in comparison to the standards

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics