Heterocyclic Building Blocks-Benzisoxazole

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Artificial enzymes based on imprinted liquid-crystalline materials

Liquid-crystal elastomers, imprinted around indole, are assessed as artificial enzymes for the isomerisation of benzisoxazole into 2-cyano phenol. Two types of material are synthesised, tested in the catalysis and compared with non-liquid-crystal imprinted polymers: an imprinted liquid-crystalline elastomer and a semi-interpenetrated imprinted liquid-crystal network. The catalytic effect of all materials is close. However, the main benefit for the liquid-crystal elastomer is shown to be the shape memory of the material at the molecular scale, because the isomerisation kinetics are found to be identical before and after deformation of the cavities either by thermal treatment up to the isotropic state or by solvent induced swelling. This fact is related to the coupling between the order and the conformation of the polymer chains, which is fixed by the crosslinking process. On the other hand, the imprinted sites of the semi-interpenetrated imprinted liquid-crystal elastomer are shown to be almost 100 times more active than the non-imprinted sites in the catalysis. This factor is only 22 for the corresponding non-liquid-crystalline network.

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Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

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Synthesis, characterization and evaluation of antioxidant and anticancer activities of novel benzisoxazole-substituted-allyl derivatives

A novel series of various 2-allylbenzo[d]isoxazol-3(2H)-ones were synthesized using benzo[d]isoxazol-3(2H)-one treated with different allyl bromides/chlorides in the presence of water-mediated cesium carbonate as a new catalyst 3(a-h). The structures of the newly synthesized Benzisoxazole-substituted-allyl derivatives were characterized by spectroscopic methods and mass spectrometry. These synthesized compounds were evaluated for their in vitro antioxidant and anticancer activity. Compounds 3b, d, f, h were identified as the best hit against HT-29 Human colon cancer cells. Similarly, compounds like 3b, d, f, h showed significant antioxidant activity compared to the standard drug butylated hydroxy toluene (BHT).

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. 868-14-4, Name is Potassium hydrogen tartrate, SMILES is [O-]C(C(C(C(O)=O)O)O)=O.[K+], in an article , author is Vijayakumar, E. K. S., once mentioned of 868-14-4, Product Details of 868-14-4.

HPLC method for simultaneous determination of impurities and degradation products in zonisamide

A gradient reversed phase HPLC method was developed and validated for the analysis of related substances in zonisamide (1,2-benzisoxazole-3-methanesulfonamide), using a Waters Symmetry C8 (150FNx013.9 mm) column with a flow rate of 1.0 ml/min and detection at 280 nm. The mobile phase component A consisted of a mixture of 0.02 M aqueous potassium dihydrogen phosphate-acetonitrile-methanol (75:10:15 v/v/v), pH adjusted to 4.0 with orthophosphoric acid. The mobile phase component B consisted of a mixture of 0.02 M aqueous potassium dihydrogen phosphate-acetonitrile-methanol (15:40:45 v/v/v), pH 2.0 with orthophosphoric acid. The limit of detection and limit of quantitation were in the range of 0.001-0.007 and 0.0035-0.25 respectively with respect to sample concentration of 2 mg/ml. The method was linear in the range of LOQ level to 200 of specified limits for II-VIII (< 0.10, r (2) = 0.9958-0.9999). The method is sensitive, specific, linear, accurate, precise and stability-indicating for the detection and quantitation of precursors (viz., 4-hydroxycoumarin, 1,2-benzisoxazole-3-acetic acid, 1,2-benzisoxazole-3-bromoacetic acid, 1,2-benzisoxazole-3-methylbromide, sodium 1,2-benzisoxazole-3-methanesulfonate), process impurities (viz., 2-hydroxyacetophenone oxime and 3,3,3-tribromomethyl-1,2-benzisoxazole) and drug degradation products formed under stress conditions. We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 868-14-4. The above is the message from the blog manager. Product Details of 868-14-4.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. In a document, author is Comanita, E, introducing its new discovery. Computed Properties of https://www.ambeed.com/products/79-14-1.html.

Synthesis and reactivity of some Mannich bases. VII. Synthesis of 3-(2-dialkylaminoethyl)-1,2-benzisoxazoles

3-(2-Dialkylaminoethyl)-1,2-benzisoxazoles (2) are accessible by direct cyclization of the corresponding Mannich bases oxime acetates (11) in refluxing benzene in the presence of anhydrous potassium carbonate. The previously known methods for ring closure to 1,2-benzisoxazole were ineffective for this class of pharmacologically relevant compounds.

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Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 503-66-2, Name is 3-Hydroxypropionic Acid (contains varying amounts of 3,3-Oxydipropionic Acid), molecular formula is C3H6O3, Application In Synthesis of 3-Hydroxypropionic Acid (contains varying amounts of 3,3-Oxydipropionic Acid), belongs to benzisoxazole compound, is a common compound. In a patnet, author is Zhang, Xiaofeng, once mentioned the new application about 503-66-2.

One-pot and catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates

A method for the catalyst-free synthesis of pyrroloquinolinediones and quinolinedicarboxylates is developed through a one-pot synthesis involving denitrogenation of azide, benzisoxazole formation, aza-Diels-Alder cycloaddition, and dehydrative aromatization. Only stoichiometric amounts of N-2 and H2O are produced as by-products. A comprehensive green chemistry metrics analysis indicated that this method is much more efficient and greener than two reported methods for the synthesis of pyrroloquinolinediones.

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Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

New Advances in Chemical Research in 2021. Irreversible inhibitors are therefore the equivalent of poisons in heterogeneous catalysis. 79-14-1, Name is 2-Hydroxyacetic acid, molecular formula is C2H4O3, Category: Benzisoxazole, belongs to benzisoxazole compound, is a common compound. In a patnet, author is Okada, M, once mentioned the new application about 79-14-1.

Effects of zonisamide on dopaminergic system

Effects of zonisamide (ZNS) on extracellular dopamine (DA), its precursor 3,4-dihydroxyphenylalanine (DOPA), its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels in the striatum as well as hippocampus of freely moving rats were studied. Intracellular DA, DOPA, DOPAC and HVA levels, as well as DOPA accumulation as an index of tyrosine hydroxylase activity in the rat brain in vivo, DA re-uptake in the striatum and hippocampus, and monoamine oxidase (MAO) activities were also determined. Acute administrations of therapeutic ZNS doses (20 and 50 mg/kg) increased striatal extracellular DOPA levels, intracellular striatal and hippocampal DOPA levels, and stimulated DOPA accumulation in both brain regions. ZNS also increased striatal and hippocampal intracellular as well as extracellular DA and MIA Levels, but decreased those of DOPAC levels. Chronic (3 weeks) administrations of therapeutic ZNS doses (20 and 50 mg/kg/day) increased intracellular DA, DOPA, DOPAC and HVA levels in striatum and hippocampus. ZNS-induced changes were greater in intracellular levels than in extracellular levels. Acute and chronic supratherapeutic ZNS dose (100 mg/kg) administration decreased intracellular levels of all substances detectable in both brain regions, and inhibited DOPA accumulation. Both subtypes of MAO (type A and type B) activities were weakly inhibited by ZNS. ZNS showed no effect on DA re-uptake in striatum nor in hippocampus. These results suggest that therapeutic ZNS doses increase DOPA accumulation as well as both intracellular and extracellular DA, DOPA and HVA levels. However, such doses also decrease extracellular and intracellular DOPAC levels by enhancing DA synthesis and/or by selectively inhibiting MAO-B activities. In addition, chronic therapeutic ZNS dose administration enhances DA synthesis, which results in increased intracellular DA, its precursor and its metabolites levels. On the other hand, both acute and chronic supratherapeutic ZNS dose administrations inhibit DA turnover. These ZNS effects on DA metabolism are at least partly involved in the mechanisms of action of ZNS.

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Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Research speed reading in 2021. Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. Formula: https://www.ambeed.com/products/15026-17-2.html, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 15026-17-2, Name is 4-(tert-Butoxy)-4-oxobutanoic acid, molecular formula is C8H14O4. In an article, author is Weyland, M.,once mentioned of 15026-17-2.

Artificial enzymes based on imprinted liquid-crystalline materials

Liquid-crystal elastomers, imprinted around indole, are assessed as artificial enzymes for the isomerisation of benzisoxazole into 2-cyano phenol. Two types of material are synthesised, tested in the catalysis and compared with non-liquid-crystal imprinted polymers: an imprinted liquid-crystalline elastomer and a semi-interpenetrated imprinted liquid-crystal network. The catalytic effect of all materials is close. However, the main benefit for the liquid-crystal elastomer is shown to be the shape memory of the material at the molecular scale, because the isomerisation kinetics are found to be identical before and after deformation of the cavities either by thermal treatment up to the isotropic state or by solvent induced swelling. This fact is related to the coupling between the order and the conformation of the polymer chains, which is fixed by the crosslinking process. On the other hand, the imprinted sites of the semi-interpenetrated imprinted liquid-crystal elastomer are shown to be almost 100 times more active than the non-imprinted sites in the catalysis. This factor is only 22 for the corresponding non-liquid-crystalline network.

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Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 719-64-2, Name is 5-Chloro-3-phenylbenzo[c]isoxazole, formurla is C13H8ClNO. In a document, author is Arava, Veera Reddy, introducing its new discovery. SDS of cas: 719-64-2.

Novel base catalysed rearrangement of sultone oximes to 1,2-benzisoxazole-3-methane sulfonate derivatives

A new process for the preparation of 1,2-benzisoxazole-3-methanesulfonates and 4-oximino-2,3dihydrobenzoxathiin- 2,2-dioxides (sultone oximes) is described. These compounds are important intermediates for the preparation of zonisamide, an anti-convulsant drug.

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Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. In a document, author is Chauhan, Jay, introducing its new discovery. Synthetic Route of 98-89-5.

One-pot synthesis of 2,1-benzisoxazoles (anthranils) by a stannous chloride-mediated tandem reduction-heterocyclization of 2-nitroacylbenzenes under neutral conditions

Classically, 2,1-benzisoxazoles (anthranils) are prepared from 2-nitroacylbenzenes by a reductive heterocyclization reaction with Sn or SnCl2 concentrated HCl. Acid sensitive functionalities are expected to be incompatible with these conditions; milder approaches to the synthesis of 2,1-benzisoxazoles would be welcomed. We demonstrate that SnCl2 center dot 2H(2)O in a 1:1 mixture of EtOAc/MeOH is capable of mediating the tandem reduction-heterocyclization of a variety of 2-nitroacylbenzenes to their corresponding 2,1-benzisoxazoles in good to excellent yields under essentially neutral conditions. Importantly, several commonly used acid-labile protecting groups, including Boc carbamate, tert-butyl ether, and tert-butyl ester, proved orthogonal to these reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.

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Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics