Heterocyclic Building Blocks-Benzisoxazole

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about Facile synthesis of 1,3,4-oxadiazoles via iodine promoted oxidative annulation of methyl-azaheteroarenes and hydrazides, the main research direction is oxadiazole preparation; methyl azaheteroarene hydrazide Kornblum oxidative cyclization.HPLC of Formula: 3326-71-4.

An oxidative sp3 C-H bond of methyl-azaheteroarenes protocol RCH3 (R = quinolin-2-yl, benzo[f]quinolin-3-yl, pyridin-2-yl, etc.) was reported for the synthesis of 1,3,4-oxadiazoles I (R1 = 2H-1,3-benzodioxol-5-yl, furan-2-yl, prop-1-en-2-yl, etc.) via [4+1] annulation with hydrazides R1C(O)NHNH2. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles I via selective oxidation of sp3 C-H bond of methyl-azaheteroarenes in the presence of I2-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.

In addition to the literature in the link below, there is a lot of literature about this compound(2-Furoic hydrazide)HPLC of Formula: 3326-71-4, illustrating the importance and wide applicability of this compound(3326-71-4).

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis, crystal structures, photoluminescence, and catalytic reactivity of novel coordination polymers (0-D, 1-D, 2-D to 3-D) constructed from cis-1,2-cyclohexanedicarboxylic acid and various bipyridyl ligands》. Authors are Lee, Yu Jin; Kim, Eun Young; Kim, Soo Hyun; Jang, Seung Pyo; Lee, Tae Geum; Kim, Cheal; Kim, Sung-Jin; Kim, Youngmee.The article about the compound:cis-Cyclohexane-1,2-dicarboxylic acidcas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O).Reference of cis-Cyclohexane-1,2-dicarboxylic acid. Through the article, more information about this compound (cas:610-09-3) is conveyed.

Six ZnII-(e,a-cis-1,2-chdc) complexes, [Zn2(1,2-chdc)2(2,2′-bpy)2(H2O)2]·H2O (1), [{Zn2(1,2-chdc)2(H2O)2(μ-bpa)}·4H2O]n (2), [{Zn2(μ-1,2-chdc)2(μ-4,4′-bpy)}·2CH3OH]n (3), [{Zn2(μ-1,2-chdc)2(μ-bpe)}·2H2O]n (4), [[{Zn2(μ-1,2-chdc)2}n-(μ-bpp)2-{Zn2(μ-1,2-hdc)2(H2O)2}]·CH3CN·2H2O]n (5), and [{Zn(μ-dtp)(μ-1,2-chdc)}2·4·5H2O]n (6) (1,2-chdc = 1,2-cyclohexanedicarboxylate), with different assistant ligands (2,2′-bipyridine (2,2′-bpy), 1,2-bis(4-pyridyl)ethane (bpa), 1,2-bis(4-pyridyl)ethylene (bpe), 1,3-bis(4-pyridyl)propane (bpp), and, 4,4′-bipyridine (4,4′-bpy) and 4,4′-dithiodipyridine (dtp)) were synthesized and their structures were determined Depending on the assistant ligands, the structures and dimensionalities of ZnII-(e,a-cis-1,2-chdc) complexes were varied. Two carboxylates in e,a-cis-1,2-chdc coordinate to ZnII ions with (11) or (10) connectivity. Photoluminescence study of the compounds 1-6 showed that emission spectra of compounds 1, 2, 4, and 5 were observed at 343 nm for 1, 419 nm for 2, 507 nm for 4, 396 nm for 5, resp., while no obvious luminescences were displayed for 3 and 6. Compound 1 catalyzed the transesterification reaction of Ph acetate with methanol, with quant. conversion to Me acetate, under the neutral conditions, while compounds 2-6 showed very slow conversions. The thermal stabilities of these complexes were also examined

There are many compounds similar to this compound(610-09-3)Reference of cis-Cyclohexane-1,2-dicarboxylic acid. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Quality Control of Methyl tetrahydrofuran-2-carboxylate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Hydroformylation of furan compounds in the presence of cobalt catalysts. Author is Mistrik, E. J..

The hydroformylation of furans, e.g., 2-methylfuran, furfural, Me 2-furanacrylate and Me 2-furancarboxylate, in the presence of Co2(CO)8 and Co2(CO)7(PPh3)2 was studied. In addition to the products of hydroformylation, hydrogenation products were identified. The relative reactivity of the furans was estimated and a reaction mechanism proposed.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Category: benzisoxazole. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Hydrolysis and interactions of D-cellobiose with polycarboxylic acids. Author is Amarasekara, Ananda S.; Wiredu, Bernard; Lawrence, Yen Maroney.

The hydrolysis of cellulose model compound D-cellobiose was studied with a series of eight common polycarboxylic acids and two monocarboxylic acids in aqueous medium using 0.500 mmol -COOH/L at 170 °C. The maleic acid showed the highest catalytic activity with turnover frequency (TOF) of 29.5 h-1. The interaction of carboxylic acids with D-cellobiose in DMSO-d6 was studied by determination of the pseudo first-order rate constant kH of anomeric -OH exchange rate in cellobiose using 1H NMR spectroscopy. The maleic, oxalic and citric acids showed infinitely large kH values indicating very strong interactions with D-cellobiose. The next highest interactions were found with phthalic acid (kH = 248.8 Hz). The FT-IR studies showed significant carboxylic acid C=O stretching frequency shifts (ΔνC=O) of 12, 13 and 10 cm-1 for maleic, oxalic and acetic acids resp. in mixtures with D-cellobiose.

There are many compounds similar to this compound(610-09-3)Category: benzisoxazole. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

HPLC of Formula: 610-09-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Chemical structure and physicochemical properties of perospirone. Author is Mukumoto, Makiko; Furuta, Ritsuko; Takimoto, Yoshiyuki; Kojima, Atsuyuki.

Perospirone, a new antipsychotic, was studied to clarify its chem. structure and physicochem. properties. The chem. structure of perospirone was confirmed by elemental anal., and UV, IR, NMR and MS studies. The physico-hem. properties were clarified by studying solubilities, hygroscopicity, m.p., pH, thermal anal., pKa, partition coefficient, powder x-ray diffraction pattern and polymorphism. An HPLC method for the anal. of the degradation products formed under severe conditions was established.

There are many compounds similar to this compound(610-09-3)HPLC of Formula: 610-09-3. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Recommanded Product: 2-Furoic hydrazide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis, characterization and biological activity of nano-sized Co(II), Ni(II), Cu(II), Pd(II) and Ru(III) complexes of tetradentate hydrazone ligand. Author is Abouzayed, Fatma I.; Emam, Sanaa M.; Abouel-Enein, Saeyda A..

Furo-(phenyldimethine)carbohydrazone (H2L) was prepared via the condensation reaction of 2-furoic acid hydrazide with terephthaldehyde by (2:1) molar ratio. Octahedral and square planar complexes were synthesized from the reaction of (H2L) ligand with chloride salts of Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) ions. All the chelates were structurally characterized by various anal. and spectral techniques. The stoichiometry of chelates was found to be 1:1, 1:2 and 1:3 (L:M) molar ratios to form sandwich, binuclear and trinuclear complexes, resp. All complexes were found to be non-electrolytic in nature on the basis of molar conductance values. The IR data showed that the ligand served as tetradentate in a neutral keto form. The ligand coordinated with all metal ions via oxygen atoms of carbonyl group and furan ring. The thermal properties of the ligand and its chelates were investigated utilizing thermogravimetry and reflected that Ru(III) complex has lower thermal stability than other complexes. X-ray diffraction spectra established nano-size for Ni(II) and Ru(III) complexes. The ESR result revealed axial symmetry with hyperfine structure for Cu(II) complex indicative of (2B1g) as a ground state. Some quantum parameters were reported in order to compare the reactivity of the compounds The biol. data indicated that all complexes have cytotoxic and antioxidant activity rather than the native ligand. Among all complexes, Ru(III) complex had excellent cytotoxic and antioxidant activity. This was due to its chem. structure and its nano-size.

There are many compounds similar to this compound(3326-71-4)Recommanded Product: 2-Furoic hydrazide. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Conformation and reactivity. I. Kinetics of the alkaline hydrolysis of the methyl cyclohexanemono- and -dicarboxylate and 4-tert-butylcyclohexanecarboxylates》. Authors are Cavell, E. A. S.; Chapman, N. B.; Johnson, M. D..The article about the compound:cis-Cyclohexane-1,2-dicarboxylic acidcas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O).Category: benzisoxazole. Through the article, more information about this compound (cas:610-09-3) is conveyed.

The preparation of pure cis- and trans-4-tert-butylcyclohexanecarboxylic acid and their Me esters was described. Heats and entropies of activation for the alk. hydrolysis of these esters in 1:1 dioxane-H2O, of Me cyclohexanecarboxylate in 1:1 and 1:3 dioxane-H2O, and of all the Me H and di-Me cyclohexanedicarboxylates in 1:3 dioxane-H2O were determined by the methods of Frost and Schwemer (CA 46, 6474h) and of Widequist (CA 46, 9954c) where necessary. Since Me trans-4-tert-butylcyclohexanecarboxylate adopted the diequatorial conformation exclusively, the reactivity in hydrolysis of an equatorial methoxycarbonyl group was characterized, also, with less certainty, that of an axial group, which was hydrolyzed at least 17 times more slowly at 30°. The methoxycarbonyl group was apparently more stable in the equatorial than in the axial conformation. The conformations of the various Me H and di-Me cyclohexanedicarboxylates were discussed in the light of the kinetics of their hydrolyses, and conformational, electrostatic, and primary steric effects in the hydrolyses were elucidated.

There are many compounds similar to this compound(610-09-3)Category: benzisoxazole. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Generic Ion Chromatography-Conductivity Detection Method for Analysis of Palladium Scavengers in New Drug Substances, published in 2019-05-17, which mentions a compound: 610-09-3, mainly applied to ion chromatog conductivity palladium scavenger drug substances, Computed Properties of C8H12O4.

The revolution of palladium-catalyzed reactions in the synthesis of new mols. has created an unprecedented need for highly efficient palladium (Pd) removal processes. Metal scavengers with very selective and efficient removal properties are being extensively applied across process research and development (PR&D) to meet very tight specifications for residual Pd levels. Anal. procedures for the determination of residual Pd are well-established; however, developing methodologies to detect a variety of Pd scavengers in multicomponent reaction mixtures is currently considered an emerging challenge in pharmaceutical anal. Herein a simple and efficient generic ion chromatog.-conductivity detection (IC-CD) method on a Dionex IonPac AS19 column in conjunction with a fully aqueous eluent profile (potassium-hydroxide-based) capable of chromatog. resolving over 10 Pd scavenger species commonly used in PR&D workflows is described. Computer-assisted separation modeling using an ACD Labs/LC simulator served to generate 3D resolution maps with excellent separation conditions that matched the outcome of subsequent exptl. data. Method validation experiments showed excellent anal. performance in linearity, recovery, repeatability, and LOQ/LOD. In addition, these same chromatog. conditions can sep. multiple anionic species and active pharmaceutical (API) counterions along with Pd scavengers in the same exptl. run. We also provide strategic examples where API counterion interferences (e.g., sulfate) can be minimized by treating the API sulfate form with barium acetate to enhance the recovery of the Pd scavenger analyte.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Pi-Boleda, Bernat; Sans, Marta; Campos, Maria; Nolis, Pau; Illa, Ona; Estevez, Juan Carlos; Branchadell, Vicenc; Ortuno, Rosa M. researched the compound: cis-Cyclohexane-1,2-dicarboxylic acid( cas:610-09-3 ).Product Details of 610-09-3.They published the article 《Studies on Cycloalkane-Based Bisamide Organogelators: A New Example of Stochastic Chiral Symmetry-Breaking Induced by Sonication》 about this compound( cas:610-09-3 ) in Chemistry – A European Journal. Keywords: cycloalkane based bisamide organogelator stochastic chiral symmetry breaking sonication; chirality; cycloalkane bisamides; physical asymmetric-induction; self-assembly; symmetry breaking; ultrasound. We’ll tell you more about this compound (cas:610-09-3).

Enantiomerically pure C16-alkyl amides derived from cis and trans cycloalkane-1,2-dicarboxylic acids, resp., have been synthesized and their behavior as organogelators has been investigated. These compounds include cis/trans diastereomeric cyclobutane and cyclohexane derivatives with the aim to explore the influence of the ring size as well as the relative configuration in their hierarchical self-assembly to form gels. High resolution 1H NMR spectroscopy studies allowed the determination of the dynamics of the gelation process in [D8]toluene and the sol-gel transition temperature The morphol. and size of the aggregates have been investigated and results have shown that, in the case of cyclobutane derivatives, the cis/trans stereochem. is not relevant for the gelation behavior and the properties of the soft-materials obtained, but it is remarkable for cyclohexane diamides, which are better organogelators. The four compounds produce chiral aggregates despite that two of them are meso achiral mols. We show herein that this fact is an example of stochastic symmetry breaking induced by sonication. The self-assembly of these mols. has been modelled providing information and support about the structure and the chirality of the aggregates.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

HPLC of Formula: 3326-71-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about BOPAHY: a doubly chelated highly fluorescent pyrrole-acyl hydrazone -BF2 chromophore. Author is Pookkandam Parambil, Shandev; de Jong, Flip; Veys, Koen; Huang, Jianjun; Veettil, Santhini Pulikkal; Verhaeghe, Davy; Van Meervelt, Luc; Escudero, Daniel; Van der Auweraer, Mark; Dehaen, Wim.

New easily functionalisable and highly fluorescent BOPAHY chromophores were synthesized via a 1-pot two-step reaction starting from com. available pyrrole-2-carbaldehydes and resp. acyl hydrazides in the presence of BF3·OEt2. Most importantly, all BOPAHY dyes show excellent photophys. properties with quantum yields up to 0.92. Steady-state spectroscopy and quantum chem. calculations provide a first insight into these promising properties.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics