Heterocyclic Building Blocks-Benzisoxazole

What I Wish Everyone Knew About 3326-71-4

There are many compounds similar to this compound(3326-71-4)SDS of cas: 3326-71-4. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis, Antifungal Activity, 3D-QSAR and Molecular Docking Study of Novel Menthol-Derived 1,2,4-Triazole-thioether Compounds, published in 2021, which mentions a compound: 3326-71-4, mainly applied to menthol derived triazole thioether preparation antifungal QSAR mol docking; 1,2,4-triazole-thioether; 3D-QSAR; antifungal activity; menthol; molecular docking, SDS of cas: 3326-71-4.

A series of novel menthol-derived triazole-thioether compounds I [R = 2-MeC6H4, 3,4-di-MeOC6H3, 2-thienyl, etc.] were designed, synthesized, characterized structurally and evaluated biol. to explore more potent natural product-based antifungal agents. The bioassay results revealed that at 50μg/mL, some of the target compounds exhibited good inhibitory activity against the tested fungi, especially against Physalospora piricola. Compounds I [R = 2-MeC6H4, 2-ClC6H4, 3,4-di-MeOC6H3, 2-furyl, etc.] had inhibition rates of 93.3%, 79.4%, and 79.4%, resp., against P. piricola, much better than that of the pos. control chlorothalonil. Compounds I [R = 3,4-di-MeOC6H3, 3-FC6H4] held inhibition rates of 82.4% and 86.5% against Cercospora arachidicola and Gibberella zeae, resp., much better than that of the com. fungicide chlorothalonil. Compound I [R = 2-MeC6H4] displayed antifungal activity of 90.5% and 83.8%, resp., against Colleterichum orbicalare and Fusarium oxysporum f. sp. cucumerinum. Compound I [R = 2-IC6H4] had inhibition rates of 88.6%, 80.0%, and 88.0%, resp., against F. oxysporum f. sp. cucumerinu, Bipolaris maydis and C. orbiculare. Furthermore, compound I [R = 2-MeC6H4] showed the best and broad-spectrum antifungal activity against all the tested fungi. To design more effective antifungal compounds against P. piricola, 3D-QSAR anal. was performed using the CoMFA method, and a reasonable 3D-QSAR model (r2 = 0.991, q2 = 0.514) was established. The simulative binding pattern of the target compounds with cytochrome P 450 14α-sterol demethylase (CYP51) was investigated by mol. docking.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

You Should Know Something about 610-09-3

There are many compounds similar to this compound(610-09-3)Safety of cis-Cyclohexane-1,2-dicarboxylic acid. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Safety of cis-Cyclohexane-1,2-dicarboxylic acid. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Potassium selectivities of bis(benzo-15-crown-5) derivatives obtained from cyclohexanedicarboxylic acids.

Several bis(benzo-15-crown-5) derivatives containing a cyclohexane or benzene ring in the bridge chain were synthesized as neutral carriers of coated-wire K+-selective electrodes. The bis(benzocrown ether) derivative obtained from cis-1,2-cyclohexanedicarboxylic acid was outstandingly K-selective.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Derivation of elementary reaction about 3326-71-4

There are many compounds similar to this compound(3326-71-4)Synthetic Route of C5H6N2O2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Huang, Mei; Duan, Wen-Gui; Lin, Gui-Shan; Li, Bao-Yu published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).Synthetic Route of C5H6N2O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Discovery of 3326-71-4

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about Facile synthesis, characterization, nucleic acid interaction and photoluminescent properties of (E)-furan-2-yl(2-(2-hydroxybenzylidene)hydrazinyl) methaniminium and its Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes, the main research direction is transition metal furanyl hydroxybenzylidene hydrazinylmethaniminium complex preparation photoluminescence; DNA binding transition metal furanyl hydroxybenzylidene hydrazinylmethaniminium complex; EPR spectra transition metal furanyl hydroxybenzylidene hydrazinylmethaniminium complex.Synthetic Route of C5H6N2O2.

The present work describes the synthesis of novel (E)-furan-2-yl(2-(2-hydroxybenzylidene)hydrazinyl) methaniminium in water/methanol(3:1) mixture, water acting as catalyst and also solvent to expedite reaction rate with high yield. In which, amine exchange and condensation reaction takes place between N-salicylidene aniline and furanoic acid hydrazide at one step. The structural characterization of prepared ligand was carried out by single crystal x-ray diffraction, elemental anal. and spectroscopy (UV-visible, FTIR and NMR) techniques. The single crystal x-ray diffraction result indicates that the ligand crystallizes in orthorhombic system with Pca21 space group. Further, Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes of ligand were prepared Complexes were analyzed by elemental anal., magnetic susceptibility and spectroscopy (UV-visible, FTIR and ESR) studies. The DNA binding studies of synthesized compounds were carried out and results suggest that, ligand L and its transition metal complexes 1-6 were binding to CT-DNA through intercalation. It was confirmed by intrinsic binding constant value in the order of 106 M-1. The fluorescence properties of ligand L and its metal complexes 1-6 were investigated; ligand showed broad emission spectra in the visible region and its metal complexes exhibited emission spectra in the blue to red.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Why Are Children Getting Addicted To 3326-71-4

Alhakamy, Nabil A.; Noor, Ahmad O.; Hosny, Khaled M.; Nasr, Jenny Jeehan; Fouda, Moustafa M. G.; Khattab, Tawfik A.; Gaffer, Hatem E. published an article about the compound: 2-Furoic hydrazide( cas:3326-71-4,SMILESS:O=C(C1=CC=CO1)NN ).Synthetic Route of C5H6N2O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3326-71-4) through the article.

The 3-cyanopyridine analogs I, II and III [Ar = 4-methylphenyl, 4-methoxyphenyl, 4-chlorophenyl, etc.] were synthesized and examined to determine their activity against the M. tuberculosis H37Rv strain. Derivatives I [2-thienyl, 4-chlorophenyl] and II [Ar = 2-furyl, 2-thienyl]had good inhibition. Further screening was done for the highest potency against M. tuberculosis to determine the MICs. The antioxidant efficacy was evaluated via the DPPH technique matched with vitamin C as a pos. control. Some synthesized derivatives displayed good potency against bacterial activity and M tuberculosis. The antioxidant performance of these derivatives did not display scavenging efficacies compared to vitamin C. The cytotoxic activity of the synthesized derivatives was also examined various cell lines to display good cytotoxic activity in the order III > II > I.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Downstream Synthetic Route Of 3326-71-4

There are many compounds similar to this compound(3326-71-4)HPLC of Formula: 3326-71-4. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Furoic hydrazide(SMILESS: O=C(C1=CC=CO1)NN,cas:3326-71-4) is researched.Name: Methanesulfonato(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)palladium(II). The article 《Tin powder promoted synthesis of α-trifluoromethyl homoallylic hydrazides》 in relation to this compound, is published in Youji Huaxue. Let’s take a look at the latest research on this compound (cas:3326-71-4).

An efficient tin powder promoted multicomponent one-pot reaction was developed for the synthesis of α-trifluoromethyl homoallylic hydrazides from Et trifluoropyruvate, hydrazides and allylic bromides in the presence of Bronsted and Lewis acid in 1,4-dioxane under reflux conditions. The method avoids the use of toxic stannanes and allows easy operation. The reaction proceeds smoothly under mild reaction conditions to give the corresponding products in good yields.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Derivation of elementary reaction about 3326-71-4

There are many compounds similar to this compound(3326-71-4)Safety of 2-Furoic hydrazide. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Russian Journal of Organic Chemistry called Synthesis and Antibacterial Activity of Novel (4-Methoxyphenyl)-tetrahydropyranyl-substituted 1,3,4-Oxadiazoles, Author is Aghekyan, A. A.; Mkryan, G. G.; Panosyan, H. A.; Safaryan, A. S.; Stepanyan, H. M., which mentions a compound: 3326-71-4, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2, Safety of 2-Furoic hydrazide.

Condensation of 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonyl chloride I [R1 = Cl] with hydrazine hydrate, furan-2- and 2,5-dimethylfuran-2-carbohydrazides gave disubstituted hydrazides II [R2 = furan-2-carbonyl, (4,5-dimethylfuran-2-carbonyl), 4-(4-methoxyphenyl)tetrahydropyran-4-carbonyl], whose cyclization formed sym. and unsym. 2,5-disubstituted 1,3,4-oxadiazoles III [R3 = 2-furyl, 4,5-dimethyl-2-furyl, 4-(4-methoxyphenyl)tetrahydropyran-4-yl]. Et 4-[4-(4-methoxyphenyl)-tetrahydro-2H-pyran-4-carboxamido]benzoate IV [R4 = CO2Et] was reacted with hydrazine to obtain N-[4-(hydrazinocarbonyl)-phenyl]-4-(4-methoxphenyl)tetrahydro-2H-pyran-4-carboxamide IV [R4 = C(O)NHNH2]. Treatment of IV [R4 = C(O)NHNH2] latter with tri-Et orthoformate gave a monosubstituted 1,3,4-oxadiazole IV [R4 = 1,3,4-oxadiazol-2-yl], and with carbon disulfide, a 5-sulfanyl-1,3,4-oxadiazole derivative IV [R4 = (5-sulfanyl-1,3,4-oxadiazol-2-yl)] was obtained. The subsequent alkylation of this derivative IV [R4 = (5-sulfanyl-1,3,4-oxadiazol-2-yl)] with 5-metoxyfuran-2-Me and benzylaminocarbonylmethyl chlorides substituted chlorides resulted in the synthesis of the corresponding novel S-substituted oxadiazole derivatives V [R5 = 5-methoxycarbonyl-2-furyl, benzylcarbamoyl]. The synthesized compounds I, II, III, IV and V were tested for their antibacterial activity.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Some scientific research about 610-09-3

There are many compounds similar to this compound(610-09-3)Name: cis-Cyclohexane-1,2-dicarboxylic acid. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Name: cis-Cyclohexane-1,2-dicarboxylic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about The effects of cis-trans configuration of cyclohexane multi-carboxylic acids on colloidal forces in dispersions: steric, hydrophobic and bridging. Author is Chandramalar, A. V. M.; Lim, Y. Y.; Leong, Y. K..

The effects of cis- and trans-1,2-, trans-1,4-cyclohexanedicarboxylic acid, 95% cis-1,3,5-cyclohexane tricarboxylic acid and cis-1,2,3,4,5,6-cyclohexanehexacarboxylic acid on the yield stress-pH behavior of concentrated ZrO2 dispersions are reported. Adsorbed cis-1,2,3,4,5,6-cyclohexanehexacarboxylic acid imparts predominantly steric interactions. It forms a steric barrier keeping the interacting particles apart. Adsorbed cis- and trans-1,2 increase the maximum yield stress and this was attributed to a hydrophobic force resulting from the part of the cyclohexane ring sticking out into the solution which is devoid of charged or hydrophilic group. Adsorbed trans-1,4 increases the maximum yield stress by ≥3-fold and its configuration favors strong bridging interaction with an adjacent particle. Predominantly, cis-1,3,5 also increases the maximum yield stress but only by 60% at the same additive concentration This was attributed to a smaller degree of bridging.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

New downstream synthetic route of 3326-71-4

There are many compounds similar to this compound(3326-71-4)Name: 2-Furoic hydrazide. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A simple and sensitive fluorescent sensor platform for Al3+ sensing in aqueous media and monitoring through combined PET and ESIPT mechanisms: practical applications in drinking water and bio-imaging, published in 2020-07-31, which mentions a compound: 3326-71-4, mainly applied to fluorescent sensor aluminum bioimging, Name: 2-Furoic hydrazide.

In this study, a novel hydrazide-based compound, (E)-N′-(5-(benzo[d]thiazol-2-yl)-2-hydroxybenzylidene)furan-2-carbohydrazide (probe BOTH, I) was designed, characterized and prepared as a fluorogenic “”turn-on”” sensor for monitoring Al3+ in near-perfect aqueous media. All emission and absorbance spectral studies were performed in HEPES/DMSO (volume/volume, 99.95/0.05, pH = 7.0) media at 25 °C. The quantum yield of probe BOTH increases considerably in the presence of Al3+. Probe BOTH could sense Al3+ at a concentration as low as 6.47 nM. Probe BOTH could sense Al3+ with high sensitivity and selectivity, and a quant. correlation of R2 = 0.9887 in the Al3+ concentration range of 0.0-20.0 equivalent To evaluate the method parameters, a validation study was performed based on different anal. parameters. The formation of complex BOTH-Al3+ (2 : 1 stoichiometry) was confirmed by 1H-NMR titration and MALDI-TOF MS, as well as Job′s methods. pH-Dependent and Benesi-Hildebrand plot studies also supported this proposed sensing mechanism. Besides, the binding mechanism of Al3+ with probe BOTH was further verified by theor. studies. Moreover, probe BOTH could be used for monitoring Al3+ in living-cells and water samples.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Chemical Research in 442903-28-8

There are many compounds similar to this compound(442903-28-8)Computed Properties of C7H5Cl2NO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Reactivity and regioselectivity in Stille couplings of 3-substituted 2,4-dichloropyridines, published in 2011-01-26, which mentions a compound: 442903-28-8, Name is Methyl 2,4-dichloronicotinate, Molecular C7H5Cl2NO2, Computed Properties of C7H5Cl2NO2.

The influence of substituents at C-3 of 2,4-dichloropyridines on their reactivity and regioselectivity in Pd-catalyzed cross-couplings is studied. As a model reaction, the (Ph3P)2PdCl2-catalyzed Stille coupling between 2-furyl(tributyl)tin and pyridines is chosen. Increased electron-withdrawing ability of a substituent at the pyridine 3-position improves the overall reactivity. Absolute selectivity for coupling at C-2 is achieved with an amino group at C-3, and the selectivity is totally reversed when the amino group is exchanged for a nitro substituent.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics