Heterocyclic Building Blocks-Benzisoxazole

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3326-71-4, is researched, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2Journal, Article, ACS Medicinal Chemistry Letters called Novel Copper(II) Complex with a 4-Acylpyrazolone Derivative and Coligand Induce Apoptosis in Liver Cancer Cells, Author is Nurmamat, Marhaba; Yan, Haili; Wang, Ru; Zhao, Huixin; Li, Yanhong; Wang, Xiaojing; Nurmaimaiti, Kaidirye; Kurmanjiang, Tamasha; Luo, Difang; Baodi, Jumagul; Xu, Guancheng; Li, Jinyu, the main research direction is preparation copper phenlmethylchlorobenzolpyrazolone furoic acidhydrazide complex; crystal structure copper phenlmethylchlorobenzolpyrazolone furoic acidhydrazide complex; anticancer liver cancer copper phenlmethylchlorobenzolpyrazolone furoic acidhydrazide complex.Related Products of 3326-71-4.

A novel pyrazolone-based copper complex [CuL(phen)(CH3OH)][CuL(phen)]·CH3CH2OH·CH3OH (P-FAH-Cu-phen) was synthesized and characterized. The asym. structural unit of P-FAH-Cu-phen was composed of two independent complex units [CuL(phen)(CH3OH)] and [CuL(phen)]:Cu12+ center with six coordination mode and Cu22+ center with five coordination mode. The growth of BEL-<7404≥ cells and H22 cells was significantly inhibited by P-FAH-Cu-phen with IC50 values of 1.175μg/mL and 1.097μg/mL, resp., which were much lower than IC50 of cisplatin for BEL-<7404≥ cells (23.32μg/mL) and H22 cells (27.5μg/mL). P-FAH-Cu-phen induced cell cycle arrest at G2/M and apoptosis in BEL-<7404≥ cells through mitochondria- and endoplasmic reticulum stress-associated pathways. Moreover, P-FAH-Cu-phen significantly suppressed the migration of BEL-<7404≥ cells and the tumor growth in H22 tumor mouse model without severe side effects and improved the survival of tumor mice. The results suggested that P-FAH-Cu-phen might be a potential drug candidate for the treatment of live cancer. Compound(3326-71-4)Related Products of 3326-71-4 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Furoic hydrazide), if you are interested, you can check out my other related articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Conformation and reactivity. I. Kinetics of the alkaline hydrolysis of the methyl cyclohexanemono- and -dicarboxylate and 4-tert-butylcyclohexanecarboxylates》. Authors are Cavell, E. A. S.; Chapman, N. B.; Johnson, M. D..The article about the compound:cis-Cyclohexane-1,2-dicarboxylic acidcas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O).Quality Control of cis-Cyclohexane-1,2-dicarboxylic acid. Through the article, more information about this compound (cas:610-09-3) is conveyed.

The preparation of pure cis- and trans-4-tert-butylcyclohexanecarboxylic acid and their Me esters was described. Heats and entropies of activation for the alk. hydrolysis of these esters in 1:1 dioxane-H2O, of Me cyclohexanecarboxylate in 1:1 and 1:3 dioxane-H2O, and of all the Me H and di-Me cyclohexanedicarboxylates in 1:3 dioxane-H2O were determined by the methods of Frost and Schwemer (CA 46, 6474h) and of Widequist (CA 46, 9954c) where necessary. Since Me trans-4-tert-butylcyclohexanecarboxylate adopted the diequatorial conformation exclusively, the reactivity in hydrolysis of an equatorial methoxycarbonyl group was characterized, also, with less certainty, that of an axial group, which was hydrolyzed at least 17 times more slowly at 30°. The methoxycarbonyl group was apparently more stable in the equatorial than in the axial conformation. The conformations of the various Me H and di-Me cyclohexanedicarboxylates were discussed in the light of the kinetics of their hydrolyses, and conformational, electrostatic, and primary steric effects in the hydrolyses were elucidated.

Compound(610-09-3)Quality Control of cis-Cyclohexane-1,2-dicarboxylic acid received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(cis-Cyclohexane-1,2-dicarboxylic acid), if you are interested, you can check out my other related articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Doherty, George A.; Yang, Ginger X.; Borges, Edite; Chang, Linda L.; MacCoss, Malcolm; Tong, Sharon; Kidambi, Usha; Egger, Linda A.; McCauley, Ermenegilda; Van Riper, Gail; Mumford, Richard A.; Schmidt, John A.; Hagmann, William K. published an article about the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8,SMILESS:O=C(C1OCCC1)OC ).Formula: C6H10O3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:37443-42-8) through the article.

A series of substituted tetrahydrofuroyl-1-phenylalanine derivatives was prepared and evaluated as VLA-4 antagonists. Substitution of the α carbon of the THF with aryl groups increased the specificity for VLA-4 vs. α4β7 while amide substitution increased the potency of the series without increasing the specificity. Substitution of the β carbon of the THF with keto or amino groups slightly improved the specificity for VLA-4 vs. α4β7 but with a significant loss in binding affinity for VLA-4.

Compound(37443-42-8)Formula: C6H10O3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Methyl tetrahydrofuran-2-carboxylate), if you are interested, you can check out my other related articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Chiral ammonium hypoiodite salt-catalyzed enantioselective oxidative cycloetherification to 2-acyl tetrahydrofurans, published in 2016, which mentions a compound: 37443-42-8, Name is Methyl tetrahydrofuran-2-carboxylate, Molecular C6H10O3, Computed Properties of C6H10O3.

Chiral quaternary ammonium hypoiodite salt-catalyzed enantioselective oxidative cycloetherification of δ-hydroxyketone derivs was achieved . The corresponding 2-acyl tetrahydrofurans were obtained in high chem. yield with high enantioselectivity.

Compound(37443-42-8)Computed Properties of C6H10O3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Methyl tetrahydrofuran-2-carboxylate), if you are interested, you can check out my other related articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Reactions of furan compounds. IV. High-temperature decomposition of the vapors of tetrahydrofuronitrile and Me tetrahydrofuroate to give 2,3-dihydrofuran and cyclopropanealdehyde》. Authors are Wilson, Christopher L..The article about the compound:Methyl tetrahydrofuran-2-carboxylatecas:37443-42-8,SMILESS:O=C(C1OCCC1)OC).SDS of cas: 37443-42-8. Through the article, more information about this compound (cas:37443-42-8) is conveyed.

Tetrahydrofuramide (I) is not dehydrated by COCl2 at high temperatures At 360-400° over silica gel, I gives a mixture of tetrahydrofuronitrile (II) and 2,3-dihydrofuran (III), together with some HCN; the yield of II at 290° was 74%, at 310° 55%, and at 330° 40% (yields are based on consumption, see Part III); over Na phosphate (pumice impregnated with 120 g. NaH2PO4 and 15 cc. H3PO4 in 85 cc. H2O and dried by heating slowly to 300°) at 400° the yield of II was 90%, consumption of I 50-85%. With N as carrier gas (2 l./hr.), 70% of II was recovered when passed over earthenware rings at 450°; 10% was impure III. Silica gel at 500° gives 20% of tetrahydrofuran (IV)-III mixture (48% of III), 10% of unchanged II and 10% of a compound (V), which may be CH2.CH2.C:CHCN, b. 130-40°. Na phosphate at 500° gives HCN, only a little III + IV and mainly cyclopropanecarboxaldehyde (VI), b14 42-4°; 2,4-dinitrophenylhydrazone, orange-red, m. 173-5°; p-nitrophenylhydrazone, golden-yellow, m. 129-32°; dimedon derivative, m. 160-2°. NH4 tetrahydrofuroate (aqueous solution containing an excess of NH3) over earthenware rings gives an equimol. mixture of the free acid and I; over silica gel at 500-600° V and II were formed; over Na phosphate, the temperature and carrier gas (N, CO2) appeared to have little influence on the results; between 450-550° there resulted 20-30% of a product b. 45-90° containing MeOH, III, and VI; over silica gel at 375°, the products were III and PrCHO (2,4-dinitrophenylhydrazone, orange-brown, m. 120-5°); at 400°, the ester gives 30% of a liquid containing some III and VI. VI was prepared in about 20% yield from Cl(CH2)3CN and SnCl2 in ether (saturated with HCl).

Compound(37443-42-8)SDS of cas: 37443-42-8 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Methyl tetrahydrofuran-2-carboxylate), if you are interested, you can check out my other related articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Maris, Mihaela; Huck, Wolf-Rudiger; Mallat, Tamas; Baiker, Alfons published the article 《Palladium-catalyzed asymmetric hydrogenation of furan carboxylic acids》. Keywords: palladium cinchonidine catalyst asym hydrogenation furan carboxylic acid.They researched the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8 ).Reference of Methyl tetrahydrofuran-2-carboxylate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:37443-42-8) here.

Enantioselective hydrogenation of aromatic and heteroaromatic compounds is the field where chirally modified metal hydrogenation catalysts have the biggest potential compared to homogeneous chiral transition metal complexes. Here we report the hydrogenation of furan and benzofuran carboxylic acids over a cinchonidine-modified 5 wt% Pd/Al2O3 catalyst. (S)-Tetrahydrofuran-2-carboxylic acid was synthesized in 4 h at rt and 30 bar with 95% yield and 32% ee. The ee was lower in the hydrogenation of methylfuran carboxylic acids but up to 100% de was achieved. In the slow hydrogenation of benzofuran-2-carboxylic acid, the ee went up to 50% at 29% yield. The potential application of the method is limited by the competing hydrogenation of the quinoline rings of cinchonidine in the latter reaction, necessitating the feeding of small amounts of cinchonidine during reaction. Still, this simple method using an easily available chiral modifier and catalyst affords the highest rate and ee reported so far in the catalytic asym. hydrogenation of furan and benzofuran carboxylic acids, and it may be an attractive route in combination with optical resolution We assume that the reaction mechanism is analogous to that described for α,β-unsaturated carboxylic acids over the same catalyst, involving a 1:2-type interaction between the cinchonidine and the acid dimer.

Compound(37443-42-8)Reference of Methyl tetrahydrofuran-2-carboxylate received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Methyl tetrahydrofuran-2-carboxylate), if you are interested, you can check out my other related articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Mistrik, E. J. published an article about the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8,SMILESS:O=C(C1OCCC1)OC ).Synthetic Route of C6H10O3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:37443-42-8) through the article.

The hydroformylation of furans, e.g., 2-methylfuran, furfural, Me 2-furanacrylate and Me 2-furancarboxylate, in the presence of Co2(CO)8 and Co2(CO)7(PPh3)2 was studied. In addition to the products of hydroformylation, hydrogenation products were identified. The relative reactivity of the furans was estimated and a reaction mechanism proposed.

Compound(37443-42-8)Synthetic Route of C6H10O3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Methyl tetrahydrofuran-2-carboxylate), if you are interested, you can check out my other related articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of New Cyanopyridine Scaffolds and their Biological Activities, published in 2020-11-30, which mentions a compound: 3326-71-4, Name is 2-Furoic hydrazide, Molecular C5H6N2O2, Safety of 2-Furoic hydrazide.

The 3-cyanopyridine analogs I, II and III [Ar = 4-methylphenyl, 4-methoxyphenyl, 4-chlorophenyl, etc.] were synthesized and examined to determine their activity against the M. tuberculosis H37Rv strain. Derivatives I [2-thienyl, 4-chlorophenyl] and II [Ar = 2-furyl, 2-thienyl]had good inhibition. Further screening was done for the highest potency against M. tuberculosis to determine the MICs. The antioxidant efficacy was evaluated via the DPPH technique matched with vitamin C as a pos. control. Some synthesized derivatives displayed good potency against bacterial activity and M tuberculosis. The antioxidant performance of these derivatives did not display scavenging efficacies compared to vitamin C. The cytotoxic activity of the synthesized derivatives was also examined various cell lines to display good cytotoxic activity in the order III > II > I.

Compound(3326-71-4)Safety of 2-Furoic hydrazide received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Furoic hydrazide), if you are interested, you can check out my other related articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Thuery, Pierre; Atoini, Youssef; Harrowfield, Jack published the article 《Crown Ethers and Their Alkali Metal Ion Complexes as Assembler Groups in Uranyl-Organic Coordination Polymers with cis-1,3-, cis-1,2-, and trans-1,2-Cyclohexanedicarboxylates》. Keywords: uranyl alkali metal crown ether cyclohexanedicarboxylate polymeric complex preparation; crystal structure uranyl alkali metal crown ether cyclohexanedicarboxylate polymer; luminescence uranyl alkali metal crown ether cyclohexanedicarboxylate polymeric complex.They researched the compound: cis-Cyclohexane-1,2-dicarboxylic acid( cas:610-09-3 ).Reference of cis-Cyclohexane-1,2-dicarboxylic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:610-09-3) here.

Alkali metal cations (Na+, K+) and crown ether mols. (12C4, 15C5, 18C6) were used as addnl. reactants during the hydrothermal synthesis of uranyl ion complexes with cis/trans-1,3-, cis-1,2- and trans-1,2-cyclohexanedicarboxylic acids (c/t-1,3-chdcH2, c-1,2-chdcH2, and t-1,2-chdcH2, resp., the latter as racemic or pure (1R,2R) enantiomer). Oxalate anions generated in situ are present in all the six complexes isolated and crystallog. characterized, [(UO2)2(c-1,3-chdc)2(C2O4)][UO2(H2O)5]·(12C4)·2H2O (1), [(UO2)4Na2(c-1,2-chdc)2(C2O4)3(15C5)2] (2), [(UO2)4K2(c-1,2-chdc)2(C2O4)3(18C6)1.5(H2O)1.5] (3), [(UO2)12K5(R-t-1,2-chdc)4(C2O4)10(18C6)5(OH)(H2O)3]·4H2O (4), [(UO2)12K5(rac-t-1,2-chdc)4(C2O4)10(18C6)5(OH)(H2O)3]·4H2O (5), and [(UO2)8K4(rac-t-1,2-chdc)4(C2O4)6(18C6)3(H2O)2] (6). In complex 1, the [UO2(H2O)5]2+ counterions link the ladderlike uranyl-containing one-dimensional polymers and the uncomplexed crown ether mols. through hydrogen bonds. In all the other complexes, two-dimensional uranyl/chdc/oxalate subunits are formed, with topologies depending on the stoichiometry, in which the 1,2-chdc2- ligands are bound to three uranium atoms, one of them chelated by the two carboxylate groups, and the oxalate ligands are bis-chelating. In complex 2, the Na(15C5)+ cations are bound to one layer through double Na-carboxylate or Na-oxo cis-bonding and they are thus mere decorating groups. In contrast, the quasi-planar K(18C6)+ groups in 3-6, partially affected by disorder, are generally trans-coordinated to two uranyl oxo groups pertaining to different layers, thus uniting the latter into a three-dimensional framework.

Compound(610-09-3)Reference of cis-Cyclohexane-1,2-dicarboxylic acid received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(cis-Cyclohexane-1,2-dicarboxylic acid), if you are interested, you can check out my other related articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nguyen, D. Thao; Lenstra, Danny C.; Mecinovic, Jasmin researched the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8 ).Name: Methyl tetrahydrofuran-2-carboxylate.They published the article 《Chemoselective calcium-catalyzed direct amidation of carboxylic esters》 about this compound( cas:37443-42-8 ) in RSC Advances. Keywords: amide green preparation chemoselective; carboxylic ester primary amine calcium catalyst amide bond formation. We’ll tell you more about this compound (cas:37443-42-8).

Unactivated carboxylic esters and primary amines undergo calcium-catalyzed direct amide bond formation to afford amides I [R1 = n-Pr, Ph, 4-hydroxybutyl, etc.; R2 = 2-thienyl, Ph, Bn, etc.] in excellent yields under homogeneous conditions in toluene. This green and mild reaction proceeds chemoselectively with esters, whereas related carboxylic acids and amides remain unreactive.

Compound(37443-42-8)Name: Methyl tetrahydrofuran-2-carboxylate received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Methyl tetrahydrofuran-2-carboxylate), if you are interested, you can check out my other related articles.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics