Heterocyclic Building Blocks-Benzisoxazole

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Dental adhesive composition

A dental adhesive composition containing as major components: (a) at least one isocyanate-group-containing urethane prepolymer, (b) at least one isocyanate-group-containing silane compound, (c) at least one radical-polymerizable unsaturated monomer, and (d) at least one initiator selected from the group consisting of redox polymerization initiators and photopolymerization initiators is disclosed. This composition is excellent in bonding properties when it is used to bond a living dental tissue with a restoring material such as a metal, organic polymer, and ceramic. Also, this adhesive composition does not require a troublesome pretreatment of the restoring material with an etching agent such as phosphoric acid when the restorating material is required to bond to the living tissue.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Reference of 36216-80-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 36216-80-5, Benzo[d]isoxazol-3-amine, introducing its new discovery.

3-Amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases

A series of benzoisoxazoles and benzoisothiazoles have been synthesized and evaluated as inhibitors of receptor tyrosine kinases (RTKs). Structure-activity relationship studies led to the identification of 3-amino benzo[d]isoxazoles, incorporating a N,N?-diphenyl urea moiety at the 4-position that potently inhibited both the vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor families of RTKs. Within this series, orally bioavailable compounds possessing promising pharmacokinetic profiles were identified, and a number of compounds demonstrated in vivo efficacy in models of VEGF-stimulated vascular permeability and tumor growth. In particular, compound 50 exhibited an ED50 of 2.0 mg/kg in the VEGF-stimulated uterine edema model and 81% inhibition in the human fibrosarcoma (HT1080) tumor growth model when given orally at a dose of 10 mg/kg/day.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Application of 4865-84-3, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. In a Patent£¬once mentioned of 4865-84-3

Process for the preparation of zonisamide and the intermediates thereof

The present invention provides a novel and improved process for the preparation of Zonisamide and the intermediates thereof. In one aspect of the present invention, the process provides for: the preparation and isolation of a novel crystalline form of anhydrous 1,2-benzisoxazole-3-methanesulfonic acid of formula 1; the direct chlorination of the acid of formula 1 into its acid chloride of formula 2; and the in situ conversion of the intermediate acid chloride of formula 2 into Zonisamide.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Electric Literature of 36216-80-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 36216-80-5, Benzo[d]isoxazol-3-amine, introducing its new discovery.

Novel one-pot cyclization of ortho substituted benzonitriles to 3-amino-1,2-benzisoxazoles

A novel one-pot synthesis of 3-amino-1,2-benzisoxazoles (iii), from ortho substituted benzonitriles (i), is described. The synthesis likely involves a SNAr reaction of an activated ortho halo or nitro group by a hydroxamate anion, followed by an intra-molecular ring closure. 3-Amino-1,2-benzisoxazoles (iii) can be generated quickly in comparable or superior yields via this one-pot procedure when compared to other methods. Reaction parameters and conditions are presented.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Electric Literature of 4865-84-3, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. In a Patent£¬once mentioned of 4865-84-3

NEW SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS

The invention relates to 3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives of general formula (I), which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture of the compounds according to the invention.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Electric Literature of 21725-69-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.21725-69-9, Name is Benzo[d]isoxazol-3-ol, molecular formula is C7H5NO2. In a Patent£¬once mentioned of 21725-69-9

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products.The present inventors have found that derivatives having a substituent introduced into the gamma-position of proline represented by the formula (I)wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Electric Literature of 4865-84-3, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. In a Patent£¬once mentioned of 4865-84-3

Imidazolothiazole compounds for the treatment of disease

Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

16263-52-8, Name is 3-Chloro-1,2-benzisoxazole, belongs to Benzisoxazole compound, is a common compound. Recommanded Product: 16263-52-8In an article, once mentioned the new research about 16263-52-8.

TRICYLIC DELTA 3-PIPERIDINES AS PHARMACEUTICALS

The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C 1-6alkanediyl; n is 1 or 2; X is–O–,–S–,–S(=O)–or–S(=O) 2–; each R 1is independently hydrogen, halogen, C 1-6alkyl, nitro, hydroxy or C 1-4alkyloxy; D is an indole, a benzisoxazole, a benzisothiazole, a 2H-benzopyranone, a phenoxyphenyl, a benzamide, a benzophenone or a benzopyrimidinone having central alpha 2-adrenoceptor antagonist activity. It further relates to their preparation, pharmaceutical use and compositions.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 66033-92-9, molecular formula is C8H7NO2, introducing its new discovery. Quality Control of 3-Methyl-1,2-benzisoxazol-6-ol

Synthesis of Oxazolo<5,4-g>-1,2-benzisoxazoles

Several oxazolo<5,4-g>-1,2-benzisoxazoles have been synthesised starting from 7-amino-6-hydroxy-3-methyl-1,2-benzisoxazole (II) following two methods.The first method involves cyclization of the schiff bases (III) obtained from II and aromatic aldehydes using N-bromosuccinimide, and in the second method cyclocondensation of II with aromatic acids is brought about in the presence of polyphosphoric acid.The title isoxazoles form a new class of heterocyclic compounds.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Related Products of 65685-55-4, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. In a Article£¬once mentioned of 65685-55-4

The effects of eugenol and epoxy-resin on the strength of a hybrid composite resin

The compatibility of different dental materials (root canal sealer and composite core build-up restoratives) is an important factor for a successful restoration. The aim of this in vitro study was to determine the effects on compressive and diametral tensile strength of a classical chemical cure composite resin (Henry Schein Composite Anterior- Posterior dental restorative) when in contact with either eugenol or an epoxy-resin (EZ-Fill) in a variety of situations: (a) eugenol or epoxy-resin added during mixing of a composite resin before c? (b) vapor exposure to cured samples; and (c) specimens placed directly in eugenol or epoxy-resin (after curing). Compressive strengths and diametral tensile strengths were tested for each group. Only the addition of eugenol during mixing with the composite resin (directly before curing) resulted in specimens that were unable to be tested, because they did not achieve a full cure or hardness. For all other groups, there were no significant differences with respect to either compressive strength (p = 0.17) or diametral tensile strength (p = 0.39). Group 1 (mixed directly with eugenol) was found to be statistically different from groups 2 through 7. Copyright

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics