Heterocyclic Building Blocks-Benzisoxazole

Safety of cis-Cyclohexane-1,2-dicarboxylic acid. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about The structural diversity and luminescent properties of Zn(II) coordination assemblies with cyclohexane (or cyclohexene) dicarboxylate anions and two positional isomeric ligands. Author is Huang, Fu-Ping; Lei, Jing-Bin; Yu, Qing; Bian, He-Dong; Yan, Shi-Ping.

Four Zn(II) coordination polymers, {[Zn(chedc)(4,4′-Hbpt)]}n (1), {[Zn3(chadc)2(4,4′-Hbpt)2(4,4′-bpt)2]·3H2O}n (2), {[Zn2(chadc)2(3,3′-Hbpt)]}n (3) and {[Zn2(chedc)2(3,3′-Hbpt)]·H2O}n (4) (chadc = cis-1,2-cyclohexanedicarboxylate anion, chedc = cis-4-cyclohexene-1,2-dicarboxylate anion, 4,4′-Hbpt = 1H-3,5-bis(4-pyridyl)-1,2,4-triazole, 3,3′-Hbpt = 1H-3,5-bis(3-pyridyl)-1,2,4-triazole) were produced by the reaction of two positional isomeric dipyridyl bridging ligands and two dicarboxylate anions with Zn(II) salts under hydrothermal conditions. Structural anal. reveals that 1 exhibits a double-chain and 2 exhibits a 3-dimensional network with a (62.10)2(64.102) topol., while 3 and 4 show similar layer structures. The luminescent properties of these complexes were briefly studied.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Recommanded Product: 37443-42-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about An efficient synthesis of 3,4-dihydropyridone via a tandem olefin isomerization-ring-closing metathesis reaction. Author is Si, Chong; Fales, Kevin R.; Boyer, Robert D.; George Njoroge, F..

Novel 3,4-dihydropyridones were efficiently prepared via a tandem olefin isomerization-ring-closing metathesis reaction catalyzed by the second-generation Grubbs catalyst. The products were further functionalized at the 5-position, providing an interesting structural motif to be evaluated in medicinal chem.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Related Products of 3326-71-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about A KHSO4 mediated facile synthesis of 2-amino-1,3,4-oxadiazole derivatives. Author is Long, Binyu; Tian, Binghua; Tang, Qiang; Hu, Xiangnan; Han, Lei; Wang, Zifan; Wang, Chenyu; Wu, Yue; Yu, Yu; Gan, Zongjie.

A novel, efficient and mild KHSO4 mediated synthesis for 2-amino-1,3,4-oxadiazoles were established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate derivatives in one pot. The reactions proceeded smoothly at room temperature and produced corresponding products in moderate to good yields. This protocol also showed good functional group tolerance.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3326-71-4, is researched, Molecular C5H6N2O2, about Lemon Juice as a Biocatalyst Under Ultrasound Irradiation: Synthesis and Pharmacological Evaluation of 2-amino-1,3,4-thiadiazoles, the main research direction is amino thiadiazole preparation green ultrasound anticancer activity inhibition; 1 3 4-thiadiazole; PEG-400; SIRT1; cytotoxicity; lemon juice; ultrasound.Name: 2-Furoic hydrazide.

An ultrasound-assisted method facilitated by lemon juice has been developed to synthesize 2-amino-1,3,4-thiadiazole derivatives I (Ar = Ph, 2-methoxy-5-nitrophenyl, pyridin-3-yl, etc.) that could act as potential anticancer agents. Accordingly, a convenient method has been developed for the rapid synthesis of this class of compounds I under a mild and non-hazardous reaction condition in good yields. The methodol. involved the reaction of various acid hydrazides ArC(O)NHNH2 with TMSNCS in the presence of lemon juice in PEG-400 at room temperature (25-30°C) under ultrasound irradiation These compounds I were assessed for their cytotoxic properties against two different metastatic breast cancer cell lines e.g., MDAMB-231 and MCF-7 and subsequently against SIRT1. The 2-amino 1,3,4-thiadiazole derivatives I (Ar = 4-methoxyphenyl, 3-methoxyphenyl, 2,3-dimethoxyphenyl, 2-methoxy-5-nitrophenyl) showed promising growth inhibition of MDAMB- 231 and MCF-7 cell lines and SIRT1 inhibition in vitro. Indeed, I (Ar = 3-methoxyphenyl) was found to be a potent inhibitor of SIRT1.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Chemoselective calcium-catalyzed direct amidation of carboxylic esters》. Authors are Nguyen, D. Thao; Lenstra, Danny C.; Mecinovic, Jasmin.The article about the compound:Methyl tetrahydrofuran-2-carboxylatecas:37443-42-8,SMILESS:O=C(C1OCCC1)OC).Quality Control of Methyl tetrahydrofuran-2-carboxylate. Through the article, more information about this compound (cas:37443-42-8) is conveyed.

Unactivated carboxylic esters and primary amines undergo calcium-catalyzed direct amide bond formation to afford amides I [R1 = n-Pr, Ph, 4-hydroxybutyl, etc.; R2 = 2-thienyl, Ph, Bn, etc.] in excellent yields under homogeneous conditions in toluene. This green and mild reaction proceeds chemoselectively with esters, whereas related carboxylic acids and amides remain unreactive.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Li, Zheqi; Jiang, Wenfeng; Wang, Huilong published an article about the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8,SMILESS:O=C(C1OCCC1)OC ).Synthetic Route of C6H10O3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:37443-42-8) through the article.

Me tetrahydro-α-furancarboxylate was prepared by esterification and hydrogenation of α-furancarboxylic acid using Ru-Pd/γ-Al2O3 as catalyst in fixed bed microreactor by a one-step process. Under optimum conditions, the product yield reached 97.2%. The catalyst activity did not deteriorate after 400 h.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

COA of Formula: C6H10O3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Selective hydrogenolysis of 2-furancarboxylic acid to 5-hydroxyvaleric acid derivatives over supported platinum catalysts. Author is Asano, Takehiro; Takagi, Hiroshi; Nakagawa, Yoshinao; Tamura, Masazumi; Tomishige, Keiichi.

The conversion of 2-furancarboxylic acid (FCA), which is produced by oxidation of furfural, to 5-hydroxyvaleric acid (5-HVA) and its ester/lactone derivatives with H2 was investigated. Monometallic Pt catalysts were effective, and other noble metals were not effective due to the formation of ring-hydrogenation products. Supports and solvents had a small effect on the performance; however, Pt/Al2O3 was the best catalyst and short chain alcs. such as methanol were better solvents. The optimum reaction temperature was about 373 K, and at higher temperature the catalyst was drastically deactivated by deposition of organic materials on the catalyst. The highest yield of target products (5-HVA, δ-valerolactone (DVL), and Me 5-hydroxyvalerate) was 62%, mainly obtained as Me 5-hydroxyvalerate (55% yield). The byproducts were mainly ring-hydrogenation compounds (tetrahydrofuran-2-carboxylic acid and its ester) and undetected ones (loss of carbon balance). The catalyst was gradually deactivated during reuses even at a reaction temperature of 373 K; however, the catalytic activity was recovered by calcination at 573 K. The reactions of various related substrates were carried out, and it was found that the O-C bond in the O-C=C structure (1,2,3-position of the furan ring) is dissociated before C=C hydrogenation while the presence and position of the carboxyl group (or methoxy carbonyl group) much affect the reactivity.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Application of 610-09-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Generic Ion Chromatography-Conductivity Detection Method for Analysis of Palladium Scavengers in New Drug Substances. Author is Zou, Lanfang; Bennett, Raffeal; Haidar Ahmad, Imad A.; Jocher, Brandon M.; Zhang, Li; Bu, Xiaodong; Mangion, Ian; Regalado, Erik L..

The revolution of palladium-catalyzed reactions in the synthesis of new mols. has created an unprecedented need for highly efficient palladium (Pd) removal processes. Metal scavengers with very selective and efficient removal properties are being extensively applied across process research and development (PR&D) to meet very tight specifications for residual Pd levels. Anal. procedures for the determination of residual Pd are well-established; however, developing methodologies to detect a variety of Pd scavengers in multicomponent reaction mixtures is currently considered an emerging challenge in pharmaceutical anal. Herein a simple and efficient generic ion chromatog.-conductivity detection (IC-CD) method on a Dionex IonPac AS19 column in conjunction with a fully aqueous eluent profile (potassium-hydroxide-based) capable of chromatog. resolving over 10 Pd scavenger species commonly used in PR&D workflows is described. Computer-assisted separation modeling using an ACD Labs/LC simulator served to generate 3D resolution maps with excellent separation conditions that matched the outcome of subsequent exptl. data. Method validation experiments showed excellent anal. performance in linearity, recovery, repeatability, and LOQ/LOD. In addition, these same chromatog. conditions can sep. multiple anionic species and active pharmaceutical (API) counterions along with Pd scavengers in the same exptl. run. We also provide strategic examples where API counterion interferences (e.g., sulfate) can be minimized by treating the API sulfate form with barium acetate to enhance the recovery of the Pd scavenger analyte.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Application In Synthesis of 2-Furoic hydrazide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Green aqueous synthesis and antimicrobial evaluation of 3,5-disubstituted 1,2,4-triazoles. Author is Beyzaei, Hamid; Malekraisi, Farideh; Aryan, Reza; Ghasemi, Behzad.

An eco-friendly and simple procedure was proposed for the synthesis of 3,5-disubstituted 1,2,4-triazoles I [R = Ph, 4-pyridyl, 2-furyl, etc.] by optimized reaction of benzamidine hydrochloride and various aryl hydrazides. The products were generated in good to high yields in one step and sufficient purity after a simple workup. Inhibitory activity of all prepared derivatives was evaluated against 10 pathogenic bacterial strains including both Gram-pos. and Gram-neg., as well as 2 mold and 1 yeast strains. The prepared derivatives showed good antimicrobial activities and 1,2,4-triazoles containing 2-hydroxynaphthalen-3-yl and 5-chlorothiophen-2-yl substituents at position 3 showed the best antifungal and antibacterial properties, resp.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Nucleophilic catalysis of p-substituted aniline derivatives in acylhydrazone formation and exchange, the main research direction is phenylimino phenol preparation; hydroxy nitrobenzaldehyde acylhydrazide imine catalyst nucleophilic addition reaction; nitrobenzylidene acylhydrazone preparation mechanism kinetics.HPLC of Formula: 3326-71-4.

A mechanistic study and superior performance of electron-rich p-substituted aniline derivatives as catalysts for efficient hydrazone formation and exchange in both protic and aprotic solvents was reported. Rigorous kinetic analyses demonstrate that imine formation with 3-hydroxy-4-nitrobenzaldehyde and aniline derivatives proceeds with unprecedented third-order kinetics in which the aldehyde consistently shows a partial order of two. Computational investigations provide insights into the mechanisms of these transformations.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics