Heterocyclic Building Blocks-Benzisoxazole

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about A highly selective aggregation-induced emission fluorogen for sensitive detection of Al3+ in living cells, the main research direction is A549 cell aggregation induced emission fluorogen aluminum; AIE; Al3+; Schiff’s base; coumarin; fluorescence probe.Application In Synthesis of 2-Furoic hydrazide.

A Schiff’s base derivative was synthesized using a condensation reaction between 8-formyl-7-hydroxy-4-methylcoumarin and furan-2-carbohydrazide that produced marked aggregation-induced emission and had excellent ability to specifically recognize aluminum ions (Al3+). This compound displayed faint fluorescence in the benign solvent DMF, and exhibited obvious green fluorescence following addition of specific amounts of water. Moreover, it exhibited strong blue fluorescence after combination with Al3+ even in the presence of other interfering ions. These exptl. results demonstrated that this derivative could be used as a fluorescence probe for Al3+. The advantages, including significant fluorescence change, high selectivity and sensitivity, and fast response, meant that this probe could be used both to detect Al3+ in water samples and for fluorescence imaging in living cells.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Product Details of 610-09-3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Analysis of the stereochemistry of cyclic dicarboxylic acids by potentiometric titration. IX. Acidic ionization of stereoisomeric cyclic 1,2-dicarboxylic acids in aqueous methanol mixtures. Author is Salakhov, M. S.; Israfilov, A. I.; Gulieva, R. S.; Mamedov, S. A..

The ionization constants of I-V were determined at 25° for potentiometric titration The cis acids were weaker than the trans acids, and the saturated acids were weaker than the unsaturated ones. The distance between ionizing carboxyls in cis-trans pairs, as calculated by the Ingold method, was apparently the same.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Naphthalimide-based probe for the detection of hypochlorite in a near-perfect aqueous solution, published in 2019-11-30, which mentions a compound: 3326-71-4, mainly applied to furanamido naphthalimide preparation hypochlorite detection fluorescent sensor; 1,8-Naphthalimide; fluorescent chemosensor; hypochlorite; theoretical calculations, Quality Control of 2-Furoic hydrazide.

A novel fluorescent turn-off sensor JM for hypochlorite was synthesized. JM showed a remarkable selectivity for ClO- over diverse competitive analytes, including reactive oxygen species (ROS), via deprotonation reaction. Detection limit for ClO- turned out to be 0.60μM. Sensor JM successfully determined ClO- in natural water samples with satisfactory recovery. The sensing mechanism of JM to hypochlorite was demonstrated by fluorescent and UV-visible spectroscopy, ESI-mass, NMR titration and TD-DFT calculations

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Synthetic Route of C8H12O4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Zinc(II) and cadmium(II) complexes with mixed 1,3-di(1H-imidazol-4-yl)benzene and cyclohexanedicarboxylate ligands: Synthesis, structure and property. Author is Chen, Zhi-Hao; Zhao, Yue; Wang, Peng; Chen, Shui-Sheng; Sun, Wei-Yin.

Eight new coordination polymers Zn(L)(cis-1,2-CHDA)| (1), Zn(L)(trans-1,3-CHDA)|·2.5H2O (2), Zn(L)(cis-1,3-CHDA)|·H2O (3), Cd(L)(cis-1,2-CHDA)|·3H2O (4), Cd2(L)2(cis-1,2-CHDA)2|·3H2O (5), Cd(L)(cis-1,3-CHDA)|·H2O (6), Cd(L)(cis-1, 4-CHDA)|·5H2O (7) and Cd(L)(cis-1,4-CHDA)| (8) were synthesized by reactions of corresponding metal salt with 1,3-di(1H-imidazol-4-yl)benzene (L) and different carboxylic acids such as 1,2-cyclohexanedicarboxylic acid (1,2-H2CHDA), 1,3-cyclohexanedicarboxylic acid (1,3-H2CHDA) and 1,4-cyclohexanedicarboxylic acid (1,4-H2CHDA), resp. The results of crystal structure anal. revealed that 4, 7 and 8 are chains, 1, 3, 5 and 6 are (3)-connected 2D networks with Point (Schlaefli) symbol of (63), while 2 is a (3,3)-connected 2D network with Point (Schlaefli) symbol of (44,62). Thermal stability and photoluminescence of the complexes were investigated. Furthermore, DFT calculations were carried out on 2-5, and 7 and 8 to discuss the temperature dependent reaction of the complexes.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 610-09-3, is researched, SMILESS is O=C([C@H]1[C@@H](C(O)=O)CCCC1)O, Molecular C8H12O4Journal, Mendeleev Communications called Spontaneous formation and stabilization of radicals during the cocrystallization of alicyclic and peroxyalicyclic dicarboxylic acids, Author is Starostin, Evgenii K.; Lalov, Andrei V.; Ignatenko, Anatolii V.; Nikishin, Gennady I., the main research direction is ESR radical cocrystn alicyclic peroxyalicyclic dicarboxylic acid.Synthetic Route of C8H12O4.

The cocrystn. of di(cis-2-carboxycyclohexylcarbonyl) peroxide and cyclohexane-1,2-dicarboxylic acid from aqueous solution affords stable 1-carboxycyclohexyl radicals, which were identified by EPR spectroscopy.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Recommanded Product: cis-Cyclohexane-1,2-dicarboxylic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Crown Ethers and Their Alkali Metal Ion Complexes as Assembler Groups in Uranyl-Organic Coordination Polymers with cis-1,3-, cis-1,2-, and trans-1,2-Cyclohexanedicarboxylates. Author is Thuery, Pierre; Atoini, Youssef; Harrowfield, Jack.

Alkali metal cations (Na+, K+) and crown ether mols. (12C4, 15C5, 18C6) were used as addnl. reactants during the hydrothermal synthesis of uranyl ion complexes with cis/trans-1,3-, cis-1,2- and trans-1,2-cyclohexanedicarboxylic acids (c/t-1,3-chdcH2, c-1,2-chdcH2, and t-1,2-chdcH2, resp., the latter as racemic or pure (1R,2R) enantiomer). Oxalate anions generated in situ are present in all the six complexes isolated and crystallog. characterized, [(UO2)2(c-1,3-chdc)2(C2O4)][UO2(H2O)5]·(12C4)·2H2O (1), [(UO2)4Na2(c-1,2-chdc)2(C2O4)3(15C5)2] (2), [(UO2)4K2(c-1,2-chdc)2(C2O4)3(18C6)1.5(H2O)1.5] (3), [(UO2)12K5(R-t-1,2-chdc)4(C2O4)10(18C6)5(OH)(H2O)3]·4H2O (4), [(UO2)12K5(rac-t-1,2-chdc)4(C2O4)10(18C6)5(OH)(H2O)3]·4H2O (5), and [(UO2)8K4(rac-t-1,2-chdc)4(C2O4)6(18C6)3(H2O)2] (6). In complex 1, the [UO2(H2O)5]2+ counterions link the ladderlike uranyl-containing one-dimensional polymers and the uncomplexed crown ether mols. through hydrogen bonds. In all the other complexes, two-dimensional uranyl/chdc/oxalate subunits are formed, with topologies depending on the stoichiometry, in which the 1,2-chdc2- ligands are bound to three uranium atoms, one of them chelated by the two carboxylate groups, and the oxalate ligands are bis-chelating. In complex 2, the Na(15C5)+ cations are bound to one layer through double Na-carboxylate or Na-oxo cis-bonding and they are thus mere decorating groups. In contrast, the quasi-planar K(18C6)+ groups in 3-6, partially affected by disorder, are generally trans-coordinated to two uranyl oxo groups pertaining to different layers, thus uniting the latter into a three-dimensional framework.

There is still a lot of research devoted to this compound(SMILES：O=C([C@H]1[C@@H](C(O)=O)CCCC1)O)Recommanded Product: cis-Cyclohexane-1,2-dicarboxylic acid, and with the development of science, more effects of this compound(610-09-3) can be discovered.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

SDS of cas: 610-09-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Fractal to monolayer growth of AgCl and Ag/AgCl nanoparticles on vanadium oxides (VOx) for visible-light photocatalysis. Author is Sharma, Mukesh; Das, Biraj; Sarmah, Jugal Charan; Hazarika, Anil; Deka, Biplab K.; Park, Young-Bin; Bania, Kusum K..

A facile and simple methodol. was adopted for the trapping of highly crystalline AgCl and Ag/AgCl nanoparticles (NPs) into the interlayer spacings of vanadium oxides (VOx). Self-organization of AgCl and Ag/AgCl-NPs on VOx was found to be governed by the nature of the dicarboxylic acids used during the synthesis of the nanocomposites. A “”fractals-like”” morphol. of the AgCl@VOx nanocomposite was achieved in the presence of cis-1,2 cyclohexanedicarboxylic acid. Heating of the AgCl@VOx nanocomposite above 68 °C resulted in the growth of polydispersed and ultrafine (3-4 nm) Ag/AgCl-NPs and its self-organization into monolayer formation on a partly crystalline VOx matrix. Change in the conformation of the dicarboxylic acid to the trans-isomer resulted in the formation of a ‘rod-like’ structure of Ag/AgCl-NPs on a highly crystalline VOx matrix. The band gaps of the nanocomposites were within the range of 1.8 to 2.9 eV. Because of such a low band gap, the synthesized nanocomposites were found to be highly active toward the photooxidation of methylene (MB) and methyl orange (MO) under sunlight.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Inorganic Chemistry called Water-Soluble Dioxidovanadium(V) Complexes of Aroylhydrazones: DNA/BSA Interactions, Hydrophobicity, and Cell-Selective Anticancer Potential, Author is Sahu, Gurunath; Banerjee, Atanu; Samanta, Rajib; Mohanty, Monalisa; Lima, Sudhir; Tiekink, Edward R. T.; Dinda, Rupam, which mentions a compound: 3326-71-4, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2, Application In Synthesis of 2-Furoic hydrazide.

Five new anionic aqueous dioxidovanadium(V) complexes, [{VO2L1,2}A(H2O)n]α (1-5), with the aroylhydrazone ligands pyridine-4-carboxylic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide (H2L1) and furan-2-carboxylic acid (3-ethoxy-2-hydroxybenzylidene)hydrazide (H2L2) incorporating different alkali metals (A = Na+, K+, Cs+) as countercation were synthesized and characterized by various physicochem. techniques. The solution-phase stabilities of 1-5 were determined by time-dependent NMR and UV-visible, and also the octanol/water partition coefficients were obtained by spectroscopic techniques. X-ray crystallog. of 2-4 confirmed the presence of vanadium(V) centers coordinated by two cis-oxido-O atoms and the O, N, and O atoms of a dianionic tridentate ligand. To evaluate the biol. behavior, all complexes were screened for their DNA/protein binding propensity through spectroscopic experiments Finally, a cytotoxicity study of 1-5 was performed against colon (HT-29), breast (MCF-7), and cervical (HeLa) cancer cell lines and a noncancerous NIH-3T3 cell line. The cytotoxicity was cell-selective, being more active against HT-29 than against other cells. In addition, the role of hydrophobicity in the cytotoxicity was explained in that an optimal hydrophobicity is essential for high cytotoxicity. Moreover, the results of wound-healing assays indicated antimigration in case of HT-29 cells. Remarkably, 1 with an IC50 value of 5.42 ± 0.15μM showed greater activity in comparison to cisplatin against the HT-29 cell line.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Palladium-catalyzed Suzuki coupling synthesis and biological activities of ten new 1,3,4-oxadiazole derivatives, published in 2020-03-31, which mentions a compound: 3326-71-4, mainly applied to chloroquinolinylthio aryloxadiazole preparation phenylboronic acid Suzuki Coupling; phenylquinolinylthio aryloxadiazole preparation antibacterial antifungal, Reference of 2-Furoic hydrazide.

Ten new 2-phenyl-5-((7-phenylquinolin-4-yl)thio)-1,3,4-oxadiazole derivatives I [R = Ph, 3-pyridyl, 4-methoxyphenyl, etc.] were synthesized and their biol. activities were reported. Dichloroquinoline on sequential reactions with different moieties such as 1,3,4-oxadiazole and phenylboronic acid gave desired target derivatives I with excellent yield. In-vitro antimicrobial activity of the synthesized compounds I was evaluated against Gram-pos. and Gram-neg. bacteria. The synthetic steps involved various bond formations such as C-S and C-C which occurred with the help of nucleophilic substitution reaction. The last synthetic step involved palladium-catalyzed Suzuki coupling reaction to afford C-C bond formation.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Studies on Cycloalkane-Based Bisamide Organogelators: A New Example of Stochastic Chiral Symmetry-Breaking Induced by Sonication, the main research direction is cycloalkane based bisamide organogelator stochastic chiral symmetry breaking sonication; chirality; cycloalkane bisamides; physical asymmetric-induction; self-assembly; symmetry breaking; ultrasound.Safety of cis-Cyclohexane-1,2-dicarboxylic acid.

Enantiomerically pure C16-alkyl amides derived from cis and trans cycloalkane-1,2-dicarboxylic acids, resp., have been synthesized and their behavior as organogelators has been investigated. These compounds include cis/trans diastereomeric cyclobutane and cyclohexane derivatives with the aim to explore the influence of the ring size as well as the relative configuration in their hierarchical self-assembly to form gels. High resolution 1H NMR spectroscopy studies allowed the determination of the dynamics of the gelation process in [D8]toluene and the sol-gel transition temperature The morphol. and size of the aggregates have been investigated and results have shown that, in the case of cyclobutane derivatives, the cis/trans stereochem. is not relevant for the gelation behavior and the properties of the soft-materials obtained, but it is remarkable for cyclohexane diamides, which are better organogelators. The four compounds produce chiral aggregates despite that two of them are meso achiral mols. We show herein that this fact is an example of stochastic symmetry breaking induced by sonication. The self-assembly of these mols. has been modelled providing information and support about the structure and the chirality of the aggregates.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics