So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Koparir, Pelin researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Reference of 2-Furoic hydrazide.They published the article 《Synthesis, antioxidant and antitumor activities of some of new cyclobutane containing triazoles derivatives》 about this compound( cas:3326-71-4 ) in Phosphorus, Sulfur and Silicon and the Related Elements. Keywords: mesityl methylcyclobutyl furanyl triazolylsulfanyl ethanone preparation antitumor antioxidant SAR. We’ll tell you more about this compound (cas:3326-71-4).
Thiosemicarbazides were obtained by the interaction of furan-2-carboxylic acid hydrazide with five different isothiocyanate (RNCS) derivatives By addition of KOH to the reaction medium, 1,2,4-triazoles derivatives I [R = Et, allyl, Ph, benzyl, 4-MeC6H4] were obtained. Compounds I were dissolved in dry acetone containing K2CO3 in the presence of 2-chloro-1-(3-methyl-3-mesitylcyclobutyl)ethanone to give 3,4,5-trisubstituted 1,2,4-triazole sulfanyl compounds II. The structures of the final compounds were confirmed by elemental analyses, FT-IR, 1H-NMR and 13C-NMR. The antioxidant and antitumor properties of the synthesized compounds were also investigated. Three of the triazole derivatives II [R = Ph, benzyl, 4-MeC6H4] displayed good antioxidant and antitumor activity in comparison to the standards
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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics