Tag: M.W:100-200

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The kinetics of the acid-catalyzed hydrolysis of the methyl esters of cyclohexanedicarboxylic acids》. Authors are Smith, Hilton A.; Scrogham, Kenneth G.; Stump, Billy L..The article about the compound:cis-Cyclohexane-1,2-dicarboxylic acidcas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O).Application of 610-09-3. Through the article, more information about this compound (cas:610-09-3) is conveyed.

Isomeric cyclohexane dicarboxylic acids (I) were made by reduction of phthalic acids: cis-1,2 (II), m. 194°; trans-1,2 (III), m. 227.5-9.4°; cis-1,3 (IV), m. 167.2-8.2°; cis-1,4 (V), m. 170-2°; and trans-1,4 (VI), m. 312-13°. Di-Me esters made by acid-catalyzed esterification with MeOH were: II, b12 124.4°; III, m. 30.2-30.8°; V, b10 131°; and VI, m. 69°. IV di-Me ester, b10 130.6°, was made from the Ag salt and MeI, whereas trans-1,3-di-Me ester (VII), b20 140°, was made from H and 1,3-C6H4(CO2Me)2 with Adams Pt catalyst. Mono-Me derivative of II, m. 68.5-9.0°, was made similarly from 2-HO2CC6H4CO2Me and H. Mono-Me derivative of III, m. 94.5-95°, was made from the acid and MeOH. Mono-Me derivative of IV, m. 66.2-7.0°, was made from the acid chloride and MeOH. By treatment of the di-Me esters with 1 equivalent KOH, mono-Me derivative of V, m. 106.6-8.6°, mono-Me derivative of VI, m. 125.6-6.8°, and mono-Me derivative of trans-1,3-I were prepared Acid-catalyzed rate constants for these esters were determined at 25°, 35°, 45°, and 55° and the heats of activation calculated Me and di-Me esters of II and III hydrolyzed most slowly, those of IV and VI most rapidly, and those of V and VII at an intermediate rate.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, antioxidant and antitumor activities of some of new cyclobutane containing triazoles derivatives, published in 2019, which mentions a compound: 3326-71-4, Name is 2-Furoic hydrazide, Molecular C5H6N2O2, Formula: C5H6N2O2.

Thiosemicarbazides were obtained by the interaction of furan-2-carboxylic acid hydrazide with five different isothiocyanate (RNCS) derivatives By addition of KOH to the reaction medium, 1,2,4-triazoles derivatives I [R = Et, allyl, Ph, benzyl, 4-MeC6H4] were obtained. Compounds I were dissolved in dry acetone containing K2CO3 in the presence of 2-chloro-1-(3-methyl-3-mesitylcyclobutyl)ethanone to give 3,4,5-trisubstituted 1,2,4-triazole sulfanyl compounds II. The structures of the final compounds were confirmed by elemental analyses, FT-IR, 1H-NMR and 13C-NMR. The antioxidant and antitumor properties of the synthesized compounds were also investigated. Three of the triazole derivatives II [R = Ph, benzyl, 4-MeC6H4] displayed good antioxidant and antitumor activity in comparison to the standards

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Shinozaki, Kohichi; Abe, Mitsuyuki; Uchiyama, Midori published an article about the compound: Methyl tetrahydrofuran-2-carboxylate( cas:37443-42-8,SMILESS:O=C(C1OCCC1)OC ).HPLC of Formula: 37443-42-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:37443-42-8) through the article.

Hydrogenation of I in R1OH (R1 = lower alkyl) in the presence of Pd black or PdO was studied. I (R = H, Me) over Pd black formed small amounts of intermediate by-product ketals (II), which were hydrogenolyzed to the main products (III). With PdO, considerable amounts of II were formed from I (R = H, Me, CH:CHCO2Me, CO2Me). The amount of II formed decreased with increasing size of both R and R1.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 37443-42-8, is researched, SMILESS is O=C(C1OCCC1)OC, Molecular C6H10O3Journal, Article, Lipids called Antitumor activity of SRI 62-834, a cyclic ether analog of ET-18-OCH3, Author is Houlihan, William J.; Lee, Mark L.; Munder, Paul G.; Nemecek, Georgina M.; Handley, Dean A.; Winslow, Christine M.; Happy, John; Jaeggi, Christian, the main research direction is SRI 62834 preparation antitumor; blood platelet aggregation inhibitor SRI 62834; tatrahydrofuran ether phospholipid analog preparation antitumor.Related Products of 37443-42-8.

SRI 62-834 (I), an analog of the antitumor agent ET-18-OCH3 in which the O atom at C atom 2 was incorporated into a 5-membered heterocycle, was prepared and exhibited good cytotoxicity in vitro against a variety of tumor cell lines and was as effective as Et-18-OCH3 given orally to mice with Meth A sarcomas. SRI 62-834 inhibited platelet-derived growth factor, possibly at the receptor level, and platelet-activating factor at the receptor level.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Sharma, Mukesh; Das, Biraj; Sarmah, Jugal Charan; Hazarika, Anil; Deka, Biplab K.; Park, Young-Bin; Bania, Kusum K. researched the compound: cis-Cyclohexane-1,2-dicarboxylic acid( cas:610-09-3 ).Recommanded Product: cis-Cyclohexane-1,2-dicarboxylic acid.They published the article 《Fractal to monolayer growth of AgCl and Ag/AgCl nanoparticles on vanadium oxides (VOx) for visible-light photocatalysis》 about this compound( cas:610-09-3 ) in Journal of Materials Chemistry A: Materials for Energy and Sustainability. Keywords: fractal growth halide silver nanoparticle dope vanadium oxide v; visible light photocatalysis. We’ll tell you more about this compound (cas:610-09-3).

A facile and simple methodol. was adopted for the trapping of highly crystalline AgCl and Ag/AgCl nanoparticles (NPs) into the interlayer spacings of vanadium oxides (VOx). Self-organization of AgCl and Ag/AgCl-NPs on VOx was found to be governed by the nature of the dicarboxylic acids used during the synthesis of the nanocomposites. A “”fractals-like”” morphol. of the AgCl@VOx nanocomposite was achieved in the presence of cis-1,2 cyclohexanedicarboxylic acid. Heating of the AgCl@VOx nanocomposite above 68 °C resulted in the growth of polydispersed and ultrafine (3-4 nm) Ag/AgCl-NPs and its self-organization into monolayer formation on a partly crystalline VOx matrix. Change in the conformation of the dicarboxylic acid to the trans-isomer resulted in the formation of a ‘rod-like’ structure of Ag/AgCl-NPs on a highly crystalline VOx matrix. The band gaps of the nanocomposites were within the range of 1.8 to 2.9 eV. Because of such a low band gap, the synthesized nanocomposites were found to be highly active toward the photooxidation of methylene (MB) and methyl orange (MO) under sunlight.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Furoic hydrazide(SMILESS: O=C(C1=CC=CO1)NN,cas:3326-71-4) is researched.Safety of Palladium(II) acetate. The article 《Design and synthesis of new pyranoquinolinone heteroannulated to triazolopyrimidine of potential apoptotic antiproliferative activity》 in relation to this compound, is published in Bioorganic Chemistry. Let’s take a look at the latest research on this compound (cas:3326-71-4).

Pyrano[3,2-c]quinoline derivatives have been synthesized and utilized to obtain various new hetero-annulated triazolopyrimidine, containing quinoline, pyran, 1,2,4-triazine and pyrimidine in good yields. Newly synthesized compounds have been characterized by spectral data and elemental anal. Most of the synthesized compounds showed moderate to weak antiproliferative activity on most cancer cell lines, especially leukemia and breast cancer cell lines. The open chain formimidic acid Et ester is slightly more potent than hetero-annulated systems. The most active compounds were further investigated for caspase activation, Bax activation and Bcl-2 down regulation compared to doxorubicin as a standard, and indeed exhibited mainly cell cycle arrest at the Pre-G1 and G2/M phases. The transcription effects of 5a and 5b on the p53 were assessed and compared with the reference doxorubicin. The results revealed an increase of 12-19 in p53 level compared to the test cells and that p53 protein level of 5a and 5b was significantly inductive (991, and 639 pg/mL, resp.) in relation to doxorubicin (1263 pg/mL).

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Product Details of 3326-71-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Synthesis, characterization and biological activity of nano-sized Co(II), Ni(II), Cu(II), Pd(II) and Ru(III) complexes of tetradentate hydrazone ligand. Author is Abouzayed, Fatma I.; Emam, Sanaa M.; Abouel-Enein, Saeyda A..

Furo-(phenyldimethine)carbohydrazone (H2L) was prepared via the condensation reaction of 2-furoic acid hydrazide with terephthaldehyde by (2:1) molar ratio. Octahedral and square planar complexes were synthesized from the reaction of (H2L) ligand with chloride salts of Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) ions. All the chelates were structurally characterized by various anal. and spectral techniques. The stoichiometry of chelates was found to be 1:1, 1:2 and 1:3 (L:M) molar ratios to form sandwich, binuclear and trinuclear complexes, resp. All complexes were found to be non-electrolytic in nature on the basis of molar conductance values. The IR data showed that the ligand served as tetradentate in a neutral keto form. The ligand coordinated with all metal ions via oxygen atoms of carbonyl group and furan ring. The thermal properties of the ligand and its chelates were investigated utilizing thermogravimetry and reflected that Ru(III) complex has lower thermal stability than other complexes. X-ray diffraction spectra established nano-size for Ni(II) and Ru(III) complexes. The ESR result revealed axial symmetry with hyperfine structure for Cu(II) complex indicative of (2B1g) as a ground state. Some quantum parameters were reported in order to compare the reactivity of the compounds The biol. data indicated that all complexes have cytotoxic and antioxidant activity rather than the native ligand. Among all complexes, Ru(III) complex had excellent cytotoxic and antioxidant activity. This was due to its chem. structure and its nano-size.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Chalenko, N.; Demchenko, A.; Syrova, G. published the article 《Synthesis of potential antiexudative preparations for 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole-(4h)-3-yl)-sulfanyl)-N-acetamide series》. Keywords: antiexudative antiinflammatory analgesic.They researched the compound: 2-Furoic hydrazide( cas:3326-71-4 ).Formula: C5H6N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3326-71-4) here.

The aim of the study was to synthesize new potential biol. active substances of derivatives of 2-((4-amino-5-(furan-2-yl)-1,2,4-triazole(4H)-3-yl)-sulfanyl)-N acetamides and determination of their structure, physico-chem. properties and anti-exudative activity (AEA). Reactions were started with furan-2-carboxylic acid hydrazide with carbon disulfide in Et alc. in the presence of potassium hydroxide to form potassium dithiocarbazinate intermediate, followed by cyclical condensation with excess hydrazine, yielding tiotriazole (1) as a white solid with a good yield. Twenty-one new compounds were synthesized in the series of derivatives of 2-((4-amino-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl) sulfanyl)-N-acetamides, their phys. and chem. characteristics have been established. The structure of the synthesized compounds is confirmed by data from elemental anal., 1H NMR spectra and chromatog. mass spectrometry. Fifteen compounds have shown antiexudative activity, among the leaders were identified seven compounds: 3.1, 3.2, 3.5, 3.9, 3.11, 3.12, 3.19, which significantly suppressed swelling by 81.5 %; 61.1 %; 70.3 %; 55.5 %; 62.9 %; 53.0 %, resp., and significantly exceeded the activity of sodium diclofenac (44 %).

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Photochemical transformations. XI. Isomerization of 1,3-cyclooctadiene》. Authors are Dauben, William G.; Cargill, Robert L..The article about the compound:cis-Cyclohexane-1,2-dicarboxylic acidcas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O).Electric Literature of C8H12O4. Through the article, more information about this compound (cas:610-09-3) is conveyed.

cf. CA 54, 22718a. Com. 1,3-cyclooctadiene (I, n2D0 1.4940, λ 228 mμ (ε 5470, alc.), 22.1 g.) in 2 l. dry Et2O irradiated 200 hrs. with a Hanovia high pressure Hg arc lamp, internal probe, type L with magnetic stirring (He atm.), the progress of irradiation followed by ultraviolet spectroscopy to disappearance of I, the Et2O evaporated at 40-50° through a 1 ft. Vigreux column, and the yellow residue distilled through a Nester-Faust 2 ft. spinning band column gave 36-41% bicyclo[4.2.0]oct-7-ene (II), C8H12, b. 131-2°, n2D0 1.4720, λ205 mμ (ε 700, alc.), nuclear magnetic resonance singlets at 4.04 and complex multiplets at 7.21, 8.47 τ, infrared spectrum identical with that of material prepared from cyclooctatetraene dibromide. NaIO4 (9.78 millimoles), 0.16 millimole KMnO4, and 0.37 millimole K2CO3 in 200 ml. H2O stirred 25 hrs. at 25° with 1.03 millimoles II, the mixture acidified with 15% H2SO4, extracted 20 hrs. with Et2O, the dried extract evaporated, and the residue triturated with petr. ether gave 105 mg. solid, recrystallized from H2O and from Et2O-petr. ether to give cis-1,2-cyclohexanedicarboxylic acid, m. 197.5-8.0°. At no time was the typical spectrum of 1,3,5-hexatriene detected in the ultraviolet absorption spectrum of the irradiated solution

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Recommanded Product: 37443-42-8. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Zirconium Oxide-Catalyzed Direct Amidation of Unactivated Esters under Continuous-Flow Conditions. Author is Rashed, Nurnobi Md.; Masuda, Koichiro; Ichitsuka, Tomohiro; Koumura, Nagatoshi; Sato, Kazuhiko; Kobayashi, Shu.

A sustainable and environmentally benign direct amidation reaction of unactivated esters with amines was developed in a continuous-flow system. A com. available amorphous zirconium oxide was found to be an efficient catalyst for this reaction. While the typical amidation of esters with amines required a stoichiometric amount of a promoter or metal activator, the present continuous-flow method enabled the direct amidation reaction under additive-free conditions with an extensive diversity towards various functional groups. High yields of the products were obtained with a nearly equimolar proportion of starting materials to reduce byproduct formation, which rendered this process applicable for use in a sequential-flow system.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics