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Synthesis of Furano<2,3-g>-1,2-benzisoxazoles

Several Furano<2,3-g>-1,2-benzisoxazoles have been synthesised by the condensation of 7-acyl-3-alkyl-6-hydroxybenz-(1,2)-isoxazoles with phenylacyl halides/ethyl bromoacetate.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Archives for Chemistry Experiments of 4865-84-3

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Enantioselective nickel-catalyzed Michael additions of azaarylacetates and acetamides to nitroalkenes

Put a nickel in it: Azaarylacetates and acetamides, which have been neglected as substrates in catalytic asymmetric synthesis, undergo highly enantioselective Michael additions to nitroalkenes in the presence of a chiral nickel(II)-bis(diamine) complex (see scheme; Bn=benzyl, MS=molecular sieves). This process is tolerant of a wide variety of azaarenes in the pronucleophile. Copyright

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Top Picks: new discover of Benzo[d]isoxazol-6-ol

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Preparation of Carboxylated Graphene Oxide/Polydimethacrylate Nanocomposites via Atom Transfer Radical Polymerization and the Mechanical Properties of Nanocomposites

Abstract: An efficient strategy for grafting and growing of Bisphenol A glycerolate dimethacrylate directly from the surface of carboxylated graphene oxide sheets is presented in this paper. The carboxylated graphene oxide-polydimethacrylate was synthesized by atom transfer radical polymerization (ATRP), to develop new biomaterials for orthopedic and dental applications with the desired mechanical properties. The initiator was covalently bonded to the carboxylated graphene oxide nanosheets and the succeeding ATRP resulted in the grafting of the polymer chains (85 wt % grafting) to the graphene surface. The prepared nanohybrid was used as filler in the formulations containing Bisphenol A glycerolate dimethacrylate for evaluation of mechanical properties. Synthesized nanohybrid and nanocomposite materials were characterized by FTIR, XRD, TGA, AFM, FE-SEM and TEM. Compressive tests revealed that the compressive strength and toughness of synthesized nanocomposites compared with the sample without filler were greatly improved by 74 and 55% respectively, and it showed a significant improvement in the mechanical properties compared to common inorganic fillers.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Top Picks: new discover of 5-Fluorobenzo[d]isoxazol-3(2H)-one

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One Base for Two Shots: Metal-Free Substituent-Controlled Synthesis of Two Kinds of Oxadiazine Derivatives from Alkynylbenziodoxolones and Amidoximes

Different 1,2-migrations and cyclizations of a variety of alkynylbenziodoxolones (EBXs) and amidoximes under one-base conditions are described. This process provides an efficient protocol for the divergent synthesis of two oxadiazine derivatives via switchable selectivity of EBXs controlled by simply varying the substituents of the amidoximes, which feature transition metal-free conditions, simple execution, and high chemoselectivity.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Discovery of 4865-84-3

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Process for the preparation of zonisamide

The present invention provides an improved process for the preparation of zonisamide or a derivative thereof comprising (a) reacting 1,2-benzisoxazole-3-methane-sulfonic acid with a halogenating agent in a first organic solvent to provide benzisoxazole methane sulfonyl halide; and, (b) reacting benzisoxazole methane sulfonyl halide with an amine in a second organic solvent to form zonisamide or a derivative thereof.

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Benzisoxazole – Wikipedia,
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A new application about 21725-69-9

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 21725-69-9 is helpful to your research. Quality Control of Benzo[d]isoxazol-3-ol

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HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which inhibit the function of the NS3 protease (also referred to herein as “serine protease”) encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS3 protease. ”

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

A new application about 5-Amino-3-methylbenzo[d]isoxazole

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PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE

There is provided a compound having Formula (I) R1-Z-R2 Formula (I) wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is -X-Y-L- or -Y-X-L- wherein either X is selected from -S(=O)(=O)- and -C(=O)-, and Y is -NR3-; or X is selected from -S(=O)(=O)- and -S-, and Y is -C(R4)(R5)-; L is an optional linker; and R3, R4 and R5 are each independently selected from H and hydrocarbyl; and wherein when R2 comprises the following structural moiety, Formula (II) wherein Q is an atom selected from the group consisting of S, O, N and C; the compound is selected from compounds of the formulae R1-C(=O)-NR3-L-R2; R1-S(=O)(=O)-C(R4)(R5)-L-R2; R1-S-C(R4)(R5)-L-R2; R1-NR3-S(=O)(=O)-L-R2; R1-NR3-C(=O)-L-R2; R1-C(R4)(R5)-S(=O)(=O)-L-R2; and R1-C(R4)(R5)-S-L-R2. These compounds are useful as 11beta-hydroxysteriod dehydrogenase inhibitors in the treatment of i.a. diabetes.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Dental releasing materials

Combining nanosized particles of a source of desired dental restorative, repair or therapeutic materials with strengthening agents in various generally nanosized form such as whiskers, fibers, particles and the like in a resin matrix provides a highly strain resistant composite which more effectively releases the therapeutic agents. The utilization of nano sized particles of the therapeutic agent in the combination enables observation of significantly improved therapeutic results.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Synthesis of 1,3-bis(heteroaryloxy)-2-hydroxypropanes as symmetrical analogs of DSCG using phase transfer catalyst and their pharmacological activities

1,3-Bis(coumarinoxy)-2-hydroxypropanes (I-III), 1,3-bis(benzisoxazoloxy)-2-hydroxypropanes (IV) and 1,3-bis(benzofuranoxy)-2-hydroxypropanes (V) have been synthesised by treating substituted hydroxycoumarins, benzisoxazoles and benzofurans respectively with epoxide in the presence of a phase transfer catalyst, and found to possess passive cutaneous anaphylaxis and antiallergic activities.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Inhibitors of Hepatitis C Virus

Macrocyclic peptides are disclosed having the general formula: wherein R3, R3?, R4, R6, R?, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics