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AUXIN-LIKE ACTIVITY OF 1,2-BENZISOXAZOLE-3-ALKANOIC ACIDS

A series of benzisoxazole-alkanoic acids, differing in the length of the side-chain, have been synthesized and their activity tested on pea stem elongation, flax root growth and shoot regeneration from tomato cotyledon explants.All compounds had little or no effect on cell elongation or root growth, but a stimulating effect on shoot induction in vitro, thus showing that their activity, like that of 1,2-benzisoxazole acetic acid. is partly independent of the side-chain and is linked to the structure of the benzisoxazole ring. – Key words: 1,2-Benzisoxazole-3-alkanoic acids; auxin-like activity; pea stem elongation; flax root growth; in vitro shoot generation.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Inhibitors of Hepatitis C Virus

Macrocyclic peptides are disclosed having the general formula: wherein R3, R?3, R4, R6, R?, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Cycloelimination-assisted combinatorial synthesis of diverse heterocyclic scaffolds of chemotherapeutic values

Recent advances in high-throughput, automated techniques combined with the identification of new therapeutic targets in genome sequencing and molecular biology have generated a need for a large collection of diverse heterocyclic scaffolds. This inspires toward the development of novel reaction sequences and linking strategies to generate libraries of diverse simple to complex heterocyclic systems. In this regard, combinatorial chemistry has emerged as an excellent technology platform for the rapid assembly of building blocks to synthesize complex molecular structures with great ease in a few synthetic steps. By means of the implementation of high-throughput screening for the biological evaluation of hits and leads, combinatorial libraries have become important assets in drug discovery and development. In the last two decades, the cyclorelease strategy that minimizes the chemical and tethering implications by releasing the intact desired target molecule in the final step of reaction has attracted much attention. Recently, a particular interest is developing in linking strategies, where loading and cleavage steps contribute to the complexity of the target structure rather than only extraneous manipulations. This review summarises the practical and high-yielding approaches of solid phase combinatorial synthesis for diverse high-purity heterocyclic skeletons of pharmacological importance involving the cycloelimination strategy.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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1,2-BENZISOXAZOLE-3-METHANE-SULFONIC ACID AMMONIUM SALT

The present invention provides substantially isolated ammonium salt of 1,2- benzisoxazole-3-methane sulfonic acid (BOS-NH4), which can be crystalline. The present invention also provides substantially chemically pure BOS-NH4, which is non- hygroscopic or slightly hygroscopic. Another aspect of the present invention is directed to processes of preparing the BOS-NH4. The present invention also provides processes for preparing l,2-benzisoxazole-3-methane-sulfonyl chloride (BOS-Cl) using the BOS-NH4. The present invention also provides processes for preparing zonisamide using the BOS-NH4 or BOS-Cl.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Archives for Chemistry Experiments of Benzo[d]isoxazol-6-ol

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Dental adhesive composition

A dental adhesive composition which can quickly be hardened even in the presence of oxygen without using a radical generating agent such as a peroxide or a photopolymerization initiator, to give high bond strength, the composition including, in specific amounts, (A) a carboxylic acid compound having a (meth)-acryloyl group and a carboxyl group, both of which are attached to an aromatic ring; (B) a bisphenol A derivative having two (meth) acryloyl groups; (C) a hydroxylalkyl (meth)acrylate; (D) a (meth)acrylate derivative having an acid group; and (E) at least one polymerization initiator selected from the group consisting of aromatic amines, aliphatic amines, and aromatic sulfinic acids; the composition being substantially free from any radical polymerization initiator.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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SUBSTITUTED (PYRIDINYLAMINO)-INDOLES

There are disclosed various compounds of the formula below, STR1 where R, R 1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer’s disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorder.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Adhesive coating material

Disclosed is an adhesive coating material for a hard tissue, which comprises (1) a polymer having an acid value of 30 to 700 and including in recurring units a hydrophobic group and two carboxyl (–COOH) groups or one carboxylic anhydride STR1 group bonded to the polymer, said carboxyl groups or carboxylic anhydride group being bonded to adjacent carbon atoms, and (2) a polymerizable vinyl compound or a mixture of said polymerizable vinyl compound and an organic titanate compound.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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DOES CHLORINATION MODIFY THE AUXIN-LIKE ACTIVITY OF 1,2-BENZISOXAZOLE-3-ACETIC ACID?

The insertion of a chlorine atom in different positions of the aromatic ring did not increase the activity of benzisoxazole acetic acid, a new synthetic growth regulator, on shoot regeneration in vitro, pea stem elongation or flax root growth.This shows that this compound behaves differently from other synthetic auxins, and suggests that its activity is mainly related to the structure of its ring.Key Word Index – Chlorinated benzisoxazolic acetic acid; auxin-like activities; in vitro shoot regeneration; pea stem elongation; flax root growth.

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Benzisoxazole – Wikipedia,
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PHOTOCURABLE RESIN COMPOSITION

An object of the present invention is to provide a photocurable resin composition having excellent thick-film curability and further excellent storage stability, and a cured product of the photocurable resin composition has a high concealing effect.The present invention is a photocurable resin composition containing components (A) to (E): a component (A): a leuco dye; a component (B): a photoacid generator; a component (C): a radical polymerizable compound (except for a (meth)acrylate having a tertiary amine skeleton); a component (D): a photoradical polymerization initiator; and a component (E): a tertiary amine compound.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Synthetic Route of 21725-69-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 21725-69-9, molcular formula is C7H5NO2, introducing its new discovery.

Synthesis of an Optically Active Octahydro-2H-pyrido<1,2-a>pyrazine Based CNS Agent

A synthesis of an optically active octahydro-2H-pyrido<1,2-a>pyrazine is presented.The key sequence involved the equilibration of an optically active cis-aldehyde to give the thermodynamic transaldehyde that was trapped by nitromethane anion.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics