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21725-69-9, Name is Benzo[d]isoxazol-3-ol, belongs to Benzisoxazole compound, is a common compound. Formula: C7H5NO2In an article, once mentioned the new application about 21725-69-9.

Discovery and structure-activity relationships of a novel series of benzopyran-based KATP openers for urge urinary incontinence

A novel series of benzopyran derivatives were synthesized and evaluated as KATP channel openers. Structure-activity relationships were investigated around 4-position of the benzopyran nucleus. Optimization of 4-substituent with some heterocyclic rings led to compound 13b bearing a benzo[d]isoxazol-3-one moiety as a potent and selective KATP channel opener in vitro. In two anesthetized rat models of myogenic bladder overactivity, compound 13b was found to inhibit spontaneous bladder contractions.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Preparation of 2-hydroxybenzamidines from 3-aminobenzisoxazoles

2-Hydroxybenzamidines have been prepared from 3-aminobenzisoxazoles by reductive cleavage of the nitrogen-oxygen bond using catalytic hydrogenation, Zn/AcOH or NiCl2/NaBH4. This ring-opening reaction can be accomplished chemoselectively in the presence of a variety of hydrogenation-sensitive functional groups including an aryl bromide, benzyl carbamate, and olefin.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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PIPERAZINE-PIPERIDINE ANTAGONISTS AND AGONISTS OF THE 5-HT1A RECEPTOR

The present invention relates to novel piperazine-piperidine compounds. The compounds are useful as 5-HT1A binding agents, particularly as 5-HT1A receptor antagonists and agonists. These compounds are useful in treating central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Some scientific research about 16263-52-8

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C7H4ClNO, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 16263-52-8, in my other articles.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Computed Properties of C7H4ClNO, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 16263-52-8, Name is 3-Chloro-1,2-benzisoxazole, molecular formula is C7H4ClNO

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products.The present inventors have found that derivatives having a substituent introduced into the gamma-position of proline represented by the formula (I)wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Discovery of 16263-52-8

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 16263-52-8, name is 3-Chloro-1,2-benzisoxazole, introducing its new discovery. name: 3-Chloro-1,2-benzisoxazole

N-coating heterocyclic compounds

A compound of the formula (I): wherein A is a hydrogen atom, an optionally substituted, unsaturated, N-containing heterocyclic group or a group of the formula (a): wherein R is an optionally substituted aryl group or an optionally substituted heterocyclic group; M is ?(CH2)n-, ?(CH2)n-O?(CH2)m-or ?(CH2)n-NH?(CH2)m-, wherein n and m are independently 0, 1 or 2; Q is an optionally substituted cycloalkylene group, an optionally substituted arylene group or an optionally substituted divalent heterocyclic group; and the moiety of the formula (b): is an optionally substituted, unsaturated, mono-, di-, tri- or tetra-cyclic, N-containing heterocyclic group which may contain additional hetero atom(s) selected from the group consisting of nitrogen, oxygen and sulfur atoms as the ring member(s), its prodrug or a pharmaceutically acceptable salt thereof.

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Archives for Chemistry Experiments of 99822-23-8

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 99822-23-8 is helpful to your research. Synthetic Route of 99822-23-8

Synthetic Route of 99822-23-8, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 99822-23-8, molcular formula is C7H4FNO2, introducing its new discovery.

NOVEL OXADIAZOLES

The present invention relates to novel oxadiazoles of Formula I, wherein, R1, L1, A, L2 and R10 are as defined in the detailed description.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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An efficient synthesis of oxazolines: Via a cascade reaction between azaoxyallyl cations and 1,2-benzisoxazoles

A formal [3 + 2] cycloaddition reaction between the C and O terminals of azaoxyallyl cations formed in situ and 1,2-benzisoxazoles has been realized. This one-pot cycloaddition method provided an effective and practical pathway to synthesize oxazoline in good yields under mild conditions. The title products exhibited unique fluorescence properties.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The Absolute Best Science Experiment for 4865-84-3

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Related Products of 4865-84-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4865-84-3, Name is 1,2-Benzisoxazole-3-acetic Acid, molecular formula is C9H7NO3. In a article£¬once mentioned of 4865-84-3

Novel Base-induced Reactions of Substituted (1,2-Benzisoxazol-3-yl)acetates

The reactions of substituted (1,2-benzisoxazol-3-yl)acetates with strong bases are described.The esters (1) and (2) having electron-donating and dialkylamino substituents undergo novel ring transformations on treatment with NaH, ButOK, or MeONa in DMF to afford the 2H-azirines (8) and the 3-iminobenzofurans (18), respectively, while under similar conditions the halogeno esters (3) dimerize to give the ethylenedicarboxylate (24).Treatment of the esters (4)-(7) having electron-withdrawing substituents with NaH in DMF results in the recovery of the starting esters.However, on treatment of the sulphinyl esters (6) with MeONa in methanol, C-S bond cleavage occurs to afford methyl arylsulphinates (27).

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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SUBSTITUTED IMIDAZO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted imidazo[1,5-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson’s disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,5-a]pyrimidine compounds described herein include substituted 2,4-dimethyl-N-phenylimidazo[1,5-a]pyrimidine-8-carboxamide compounds and variants thereof.

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Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

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Indoline -1H- pyrazolo [3,4-d] pyrimidinone compound, as well as preparation method and application thereof (by machine translation)

The present invention relates to a compound of Formula (I), or a pharmaceutically acceptable salt, thereof, which may be better selective Wee1 as a new generation, selective inhibitor Wee1 with respect to the existing, inhibitor Wee1 for, Kinase more safe and higher treatment index, and thus has better safety and broader application range, for treatment, of various tumors including brain tumors. (by machine translation)

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Reference£º
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics