Tag: M.W:100-200

Formula: C8H12O4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Stimulation of pollen tube growth in vitro by dicarboxylic acids. Author is Iwanami, Y..

At 50 ppm, capric acid [334-48-5] and 2-decenoic acid [3913-85-7] almost totally inhibited the germination of Camellia japonica pollen. Moderate inhibition was shown by traumatic acid [6402-36-4], caprylic acid [124-07-2], and IAA [87-51-4]. The above compounds also inhibited pollen tube elongation. At 10 ppm, oxalic acid [144-62-7], succinic acid [110-15-6], suberic acid [505-48-6], adipic acid [124-04-9], sebacic acid [111-20-6], cis-1,2-cyclohexanedicarboxylic acid [610-09-3], and 3,3-diethylglutaric acid [4160-95-6] stimulated pollen tube elongation.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 37443-42-8, is researched, Molecular C6H10O3, about Synthesis of the alkyl esters of α-furoic acid as flavors, the main research direction is furoic acid ester preparation flavoring material.Name: Methyl tetrahydrofuran-2-carboxylate.

The seven alkyl esters of α-furoic acid were synthesized in 80-95.6% yields by refluxing the solution of benzene (or toluene) containing 0.1 mol α-furoic acid and the corresponding aliphatic alcs. (0.12∼0.5 mol) for 3 h in the presence of p-toluenesulfonic acid (0.01 mol) and 5 mL 30% hydrogen peroxide.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3326-71-4, is researched, SMILESS is O=C(C1=CC=CO1)NN, Molecular C5H6N2O2Journal, Polyhedron called Investigation of DNA interaction and antiproliferative activity of mixed ligand dioxidomolybdenum(VI) complexes incorporating ONO donor aroylhydrazone ligands, Author is Dinda, Rupam; Panda, Arpita; Banerjee, Atanu; Mohanty, Monalisa; Pasayat, Sagarika; Tiekink, Edward R. T., the main research direction is molybdenum oxo Schiff arylhydrazone hydroxybenzaldehyde complex preparation redox potential; antitumor DNA binding molybdenum oxo Schiff arylhydrazone hydroxybenzaldehyde complex; crystal structure molybdenum oxo Schiff arylhydrazone hydroxybenzaldehyde complex.COA of Formula: C5H6N2O2.

Four new mixed ligand dioxidomolybdenum(VI) [MoVIO2L1-3(Q)] (1-3), [MoVIO2L4(Q)]2 (H2O) (4) [where Q = MeOH for 1 and imidazole for 2-4] complexes were synthesized using four different ONO donor aroylhydrazone ligands (H2L1-4). All the derived ligands and complexes were characterized by different physicochem. techniques, i.e., elemental anal., spectroscopic methods (UV-Vis, NMR and IR), and cyclic voltammetry. The mol. geometries of 1-4 were established by X-ray crystallog. which reveals the Schiff base ligands coordinate – the distorted octahedral metal centers in a di-neg. tridentate fashion. The complexes indicated moderate binding affinity (103 to 104 M-1) towards CT-DNA. Further, in vitro cytotoxicity activity of all the complexes were determined against HT-29 (colon cancer) and HeLa (cervical cancer) cell lines. Complex 4, due to the presence of a heterocyclic 2-hydroxy-1-naphthyl moiety in the ligand backbone, was found to be more biol. active in comparison to the others in the series.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about An efficient water-soluble fluorescent chemosensor based on furan Schiff base functionalized PEG for the sensitive detection of Al3+ in pure aqueous solution, the main research direction is water soluble fluorescent chemosensor furan Schiff base PEG aluminum.COA of Formula: C5H6N2O2.

Furan Schiff base functionalized PEG (PEGFB) was synthesized as an excellent reversible fluorescent chemosensor for the sensitive detection of Al3+ in 100% aqueous solution The non-fluorescent PEGFB displayed high selectivity towards Al3+ over other coexistent metal ions, accompanied by a visual fluorescence change from colorless to bright cyan. The detection limit of PEGFB towards Al3+ was determined to be 7.90 x 10-9 M. PEGFB could be utilized to detect Al3+ in a relatively wide pH range from 5 to 9. The reversible fluorescence response of PEGFB upon the addition of Al3+ and EDTA was successfully used to construct an INHIBIT mol. logic gate. Furthermore, test strips coated with PEGFB could be applied for the convenient and visual sensing of Al3+ in real water samples.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

HPLC of Formula: 3326-71-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Photophysics of proton transfer in hydrazides: a combined theoretical and experimental analysis towards OLED device application. Author is Mohan, Makesh; Satyanarayan, M. N.; Trivedi, Darshak R..

Hydrazides generate phototautomers and thus, a mechanistic interpretation to uncover the excited state dynamics of such systems is highly necessary to theorize principles based on exptl. speculations. Accordingly, focus on the proton transfer barrier, which is a questionable step-wise or hypothetical simultaneous double proton transfer on structurally favored species, is quintessential; however, to the best of our knowledge, theor. insights into such findings remain rare. Thus, TX, PX and FX (where X = 2 and 3) were designed and synthesized by incorporating hydrazides, which exhibit the phenomenon of excited state intramol. proton transfer (ESIPT). Some of the mols. exhibited electroluminescence when employed as an active emitter material in fabricated OLED devices. Theor. predictions support the presence of extended conjugation in TX, PX and FX (where X = 2 and 3) to support ESIPT efficiently in comparison with TX, PX and FX (where X = 1). The solvatochromic study revealed that TX, PX and FX (where X = 2 and 3) exhibit a distinct double peak in THF solvent, characteristic of ESIPT. Interestingly, for some of the mols., emission in thin film form showed a double peak, which indicates ESIPT in the solid state. However, it was found that aggregation induced emission (AIE) was inactive in these mols. The geometrical attributes of the mols. and the nature of electronic orbital distribution well underline the principle supporting excited state proton translocation. The theor. estimated energy transitions exhibited good correlation with the exptl. results. Also, the potential energy scans revealed the mols. possess a lower forward barrier at their excited state in comparison with that of their ground state, promoting ESIPT. The potential energy surface scans performed on structurally favored species confirmed the impossible double proton transfer and highly difficult step-wise double proton transfer.

This literature about this compound(3326-71-4)HPLC of Formula: 3326-71-4has given us a lot of inspiration, and I hope that the research on this compound(2-Furoic hydrazide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 610-09-3, is researched, Molecular C8H12O4, about Hydrolysis and interactions of D-cellobiose with polycarboxylic acids, the main research direction is hydrolysis cellobiose polycarboxylate; Cellobiose; Glucose; Hydrolysis; Maleic acid; Polycarboxylic acids.Computed Properties of C8H12O4.

The hydrolysis of cellulose model compound D-cellobiose was studied with a series of eight common polycarboxylic acids and two monocarboxylic acids in aqueous medium using 0.500 mmol -COOH/L at 170 °C. The maleic acid showed the highest catalytic activity with turnover frequency (TOF) of 29.5 h-1. The interaction of carboxylic acids with D-cellobiose in DMSO-d6 was studied by determination of the pseudo first-order rate constant kH of anomeric -OH exchange rate in cellobiose using 1H NMR spectroscopy. The maleic, oxalic and citric acids showed infinitely large kH values indicating very strong interactions with D-cellobiose. The next highest interactions were found with phthalic acid (kH = 248.8 Hz). The FT-IR studies showed significant carboxylic acid C=O stretching frequency shifts (ΔνC=O) of 12, 13 and 10 cm-1 for maleic, oxalic and acetic acids resp. in mixtures with D-cellobiose.

This literature about this compound(610-09-3)Computed Properties of C8H12O4has given us a lot of inspiration, and I hope that the research on this compound(cis-Cyclohexane-1,2-dicarboxylic acid) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Conformation and reactivity. I. Kinetics of the alkaline hydrolysis of the methyl cyclohexanemono- and -dicarboxylate and 4-tert-butylcyclohexanecarboxylates》. Authors are Cavell, E. A. S.; Chapman, N. B.; Johnson, M. D..The article about the compound:cis-Cyclohexane-1,2-dicarboxylic acidcas:610-09-3,SMILESS:O=C([C@H]1[C@@H](C(O)=O)CCCC1)O).Reference of cis-Cyclohexane-1,2-dicarboxylic acid. Through the article, more information about this compound (cas:610-09-3) is conveyed.

The preparation of pure cis- and trans-4-tert-butylcyclohexanecarboxylic acid and their Me esters was described. Heats and entropies of activation for the alk. hydrolysis of these esters in 1:1 dioxane-H2O, of Me cyclohexanecarboxylate in 1:1 and 1:3 dioxane-H2O, and of all the Me H and di-Me cyclohexanedicarboxylates in 1:3 dioxane-H2O were determined by the methods of Frost and Schwemer (CA 46, 6474h) and of Widequist (CA 46, 9954c) where necessary. Since Me trans-4-tert-butylcyclohexanecarboxylate adopted the diequatorial conformation exclusively, the reactivity in hydrolysis of an equatorial methoxycarbonyl group was characterized, also, with less certainty, that of an axial group, which was hydrolyzed at least 17 times more slowly at 30°. The methoxycarbonyl group was apparently more stable in the equatorial than in the axial conformation. The conformations of the various Me H and di-Me cyclohexanedicarboxylates were discussed in the light of the kinetics of their hydrolyses, and conformational, electrostatic, and primary steric effects in the hydrolyses were elucidated.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Cyclohexane-1,2-dicarboxylic acid, is researched, Molecular C8H12O4, CAS is 610-09-3, about Generic Ion Chromatography-Conductivity Detection Method for Analysis of Palladium Scavengers in New Drug Substances, the main research direction is ion chromatog conductivity palladium scavenger drug substances.Formula: C8H12O4.

The revolution of palladium-catalyzed reactions in the synthesis of new mols. has created an unprecedented need for highly efficient palladium (Pd) removal processes. Metal scavengers with very selective and efficient removal properties are being extensively applied across process research and development (PR&D) to meet very tight specifications for residual Pd levels. Anal. procedures for the determination of residual Pd are well-established; however, developing methodologies to detect a variety of Pd scavengers in multicomponent reaction mixtures is currently considered an emerging challenge in pharmaceutical anal. Herein a simple and efficient generic ion chromatog.-conductivity detection (IC-CD) method on a Dionex IonPac AS19 column in conjunction with a fully aqueous eluent profile (potassium-hydroxide-based) capable of chromatog. resolving over 10 Pd scavenger species commonly used in PR&D workflows is described. Computer-assisted separation modeling using an ACD Labs/LC simulator served to generate 3D resolution maps with excellent separation conditions that matched the outcome of subsequent exptl. data. Method validation experiments showed excellent anal. performance in linearity, recovery, repeatability, and LOQ/LOD. In addition, these same chromatog. conditions can sep. multiple anionic species and active pharmaceutical (API) counterions along with Pd scavengers in the same exptl. run. We also provide strategic examples where API counterion interferences (e.g., sulfate) can be minimized by treating the API sulfate form with barium acetate to enhance the recovery of the Pd scavenger analyte.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

Synthetic Route of C6H10O3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Antitumor activity of SRI 62-834, a cyclic ether analog of ET-18-OCH3. Author is Houlihan, William J.; Lee, Mark L.; Munder, Paul G.; Nemecek, Georgina M.; Handley, Dean A.; Winslow, Christine M.; Happy, John; Jaeggi, Christian.

SRI 62-834 (I), an analog of the antitumor agent ET-18-OCH3 in which the O atom at C atom 2 was incorporated into a 5-membered heterocycle, was prepared and exhibited good cytotoxicity in vitro against a variety of tumor cell lines and was as effective as Et-18-OCH3 given orally to mice with Meth A sarcomas. SRI 62-834 inhibited platelet-derived growth factor, possibly at the receptor level, and platelet-activating factor at the receptor level.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics

COA of Formula: C5H6N2O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Furoic hydrazide, is researched, Molecular C5H6N2O2, CAS is 3326-71-4, about Spatial structure, thermodynamics and kinetics of formation of hydrazones derived from pyridoxal 5′-phosphate and 2-furoic, thiophene-2-carboxylic hydrazides in solution.

The spatial structure of pyridoxal 5′-phosphate hydrazones of 2-furoic hydrazide; thiophene-2-carboxylic hydrazide in aqueous solution was studied by means of quantum chem. calculations and NOE experiment The hydrazones could exist as a mixture of different conformers; however, the specific ones could be suggested from exptl. and calculated data. The stability constants of hydrazones at pH of 1.9; 6.6; 7.0; 7.4 were determined using UV-Vis spectroscopy. Rate constants of the hydrazone formation and hydrolysis reaction within the range of 6.6-7.4 pH were obtained. Isothermal calorimetric titration was performed in order to determine the change in the free Gibbs energy, enthalpy and entropy of hydrazones formation at pH of 6.6. Hydrazones were synthesized and characterized by means of 1H, 13C, 31P NMR, IR, UV-Vis, fluorescent, MS-spectroscopy as well as DSC and elemental anal.

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Reference:
Benzisoxazole – Wikipedia,
Benzisoxazole – an overview | ScienceDirect Topics