Tag: M.W:100-200

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Research speed reading in 2021. Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. HPLC of Formula: https://www.ambeed.com/products/503-74-2.html, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 503-74-2, Name is 3-Methylbutanoic acid, molecular formula is C5H10O2. In an article, author is Drevin, Guillaume,once mentioned of 503-74-2.

Death following an intramuscular injection of paliperidone: A case report

Paliperidone (9-hydroxyrisperidone), the primary active metabolite of risperidone, is a benzisoxazole derivative of the second-generation antipsychotics. Paliperidone patmitate or PP (the patmitate ester of paliperidone) is available as a once-daily oral tablet, a once-monthly injection or PP1M, and a 3-monthly injection or PP3M (marketed under the name of Trevicta (R) in the European Union). Despite the recent availability of PP3M, several cases of intoxication have been reported worldwide, including lethal cases. However, in Europe, no case of fatal poising has been reported to date. A 33-year-old man was found dead in his room at his parents’ home. His only medical background was a history of schizophrenia. The external examination was without any particularity except a runny nose of brownish liquid with an alcoholic smell. Given the context and the tack of evidence of a third party intervention, an autopsy was not considered necessary. Toxicological analysis of right femoral blood highlighted the presence of paliperidone (240 mu g/ L) only. The risk associated with the use of PP3M formulation is still imperfectly evaluated and several cases of intoxication have been reported worldwide, including fatal cases. In this case, paliperidone poisoning appears to be the highly likely cause of death. In fact, the blood concentration of paliperidone is high, twice the toxicity threshold used in therapeutic monitoring, and no other substances have been identified. This case highlights: the necessity to always evaluate the benefit-risk balance when prescribing this sustained-release form of paliperidone and the difficulties in interpreting paliperidone concentration in forensic cases. (C) 2019 Societe Francaise de Toxicologie Analytique. Published by Elsevier Masson SAS. All rights reserved.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. 868-14-4, Name is Potassium hydrogen tartrate, SMILES is [O-]C(C(C(C(O)=O)O)O)=O.[K+], in an article , author is Vijayakumar, E. K. S., once mentioned of 868-14-4, Product Details of 868-14-4.

HPLC method for simultaneous determination of impurities and degradation products in zonisamide

A gradient reversed phase HPLC method was developed and validated for the analysis of related substances in zonisamide (1,2-benzisoxazole-3-methanesulfonamide), using a Waters Symmetry C8 (150FNx013.9 mm) column with a flow rate of 1.0 ml/min and detection at 280 nm. The mobile phase component A consisted of a mixture of 0.02 M aqueous potassium dihydrogen phosphate-acetonitrile-methanol (75:10:15 v/v/v), pH adjusted to 4.0 with orthophosphoric acid. The mobile phase component B consisted of a mixture of 0.02 M aqueous potassium dihydrogen phosphate-acetonitrile-methanol (15:40:45 v/v/v), pH 2.0 with orthophosphoric acid. The limit of detection and limit of quantitation were in the range of 0.001-0.007 and 0.0035-0.25 respectively with respect to sample concentration of 2 mg/ml. The method was linear in the range of LOQ level to 200 of specified limits for II-VIII (< 0.10, r (2) = 0.9958-0.9999). The method is sensitive, specific, linear, accurate, precise and stability-indicating for the detection and quantitation of precursors (viz., 4-hydroxycoumarin, 1,2-benzisoxazole-3-acetic acid, 1,2-benzisoxazole-3-bromoacetic acid, 1,2-benzisoxazole-3-methylbromide, sodium 1,2-benzisoxazole-3-methanesulfonate), process impurities (viz., 2-hydroxyacetophenone oxime and 3,3,3-tribromomethyl-1,2-benzisoxazole) and drug degradation products formed under stress conditions. We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 868-14-4. The above is the message from the blog manager. Product Details of 868-14-4.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 40052-13-9, Name is 3-Tert-butoxy-3-oxopropanoic acid, SMILES is CC(C)(C)OC(=O)CC(O)=O, in an article , author is Bhaskarachar, Ravi Kiran, once mentioned of 40052-13-9, Product Details of 40052-13-9.

Design, synthesis and anticancer activity of functionalized spiro-quinolines with barbituric and thiobarbituric acids

A new series of spiro-quinoline compounds have been accomplished by the reaction of barbituric acid or thiobarbituric acid with derivatives of benzisoxazole-5-carbaldehyde or 2-substituted benzaldehyde. These compounds were evaluated for their in vitro cytotoxicity on two mammalian cancer cell lines MCF-7 and KB. The compounds exhibit cytotoxicity against these cell lines in micromolar range. Among the series of compounds, 11(a-j) particularly 11b and 11e showed relatively good activity against both the tested cell lines. Compound 11b was found to exhibit the highest cytotoxic activity with IC50 value 90.2 mu M for MCF-7 and 49.8 mu M for KB cell line. Flow cytometric analysis study confirmed that these molecules induced cytotoxicity via apoptosis.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 526-83-0, Name is 2,3-Dihydroxysuccinic acid, SMILES is O=C(O)C(O)C(O)C(O)=O, in an article , author is COUTINHO, DLM, once mentioned of 526-83-0, SDS of cas: 526-83-0.

SYNTHESIS OF HETEROCYCLES FROM 4-(2-HYDROXYBENZOYL)-1-PHENYLPYRAZOLE

4-(2-Hydroxybenzoyl)-1-phenylpyrazole (1) has been used in the synthesis of benzofuran (2), coumarin (5) and benzisoxazole (9).

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 619-05-6, Name is 3,4-Diaminobenzoic acid, SMILES is O=C(O)C1=CC=C(N)C(N)=C1, in an article , author is RICCI, A, once mentioned of 619-05-6, COA of Formula: https://www.ambeed.com/products/619-05-6.html.

AUXIN-LIKE ACTIVITY OF 1,2-BENZISOXAZOLE-3-ALKANOIC ACIDS

A series of benzisoxazole-alkanoic acids, differing in the length of the side-chain, have been synthesized and their activity tested on pea stem elongation, flax root growth and shoot regeneration from tomato cotyledon explants. All compounds had little or no effect on cell elongation or root growth, but a stimulating effect on shoot induction in vitro, thus showing that their activity, like that of 1,2-benzisoxazole acetic acid, is partly independent of the side-chain and is linked to the structure of the benzisoxazolic ring.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. In a document, author is Marino, Jehan, introducing its new discovery. COA of Formula: https://www.ambeed.com/products/123-76-2.html.

Iloperidone for the Treatment of Schizophrenia

OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, and safety data of iloperidone for the treatment of schizophrenia. DATA SOURCES: Data were selected by searching Pre-MEDLINE, MEDLINE, and International Pharmaceutical Abstracts (1966 January 2010). Abstracts, scientific posters, and unpublished data provided by the manufacturer in the English language were also assessed. STUDY SELECTION AND DATA EXTRACTION: All published data including pharmacologic, pharmacokinetic, pharmacodynamic, and clinical studies related to iloperidone were considered for inclusion. Selected studies included randomized controlled trials, abstracts, and posters presented at national scientific meetings providing pertinent data. data synthesis: Iloperidone is a benzisoxazole phenylethanone with a higher affinity for serotonin-2a than dopamine-2 receptors. The recommended therapeutic total daily dose is 12-24 mg divided in 2 doses titrated over 1 week to avoid orthostasis. Acute, 6-week, randomized, placebo-controlled, and active-controlled studies demonstrated iloperidone’s efficacy in reducing psychotic symptoms according to changes in the total positive and negative symptom scale (PANSS-T) score from baseline. A long-term maintenance trial demonstrated similar efficacy with haloperidol in preventing time to relapse. Pharmacogenomic studies reported possible single nucleotide polymorphisms related to QT interval prolongation and efficacy with iloperidone. Common adverse effects included dizziness, dry mouth, and sustained orthostasis occurring more frequently with higher doses. Weight gain is possible at any dose. Additionally, studies showed that QTc interval prolongation may be dose related. The incidence of extrapyramidal symptoms appears to be low across all dosage ranges; however, akathisia may be more frequent with higher doses. CONCLUSIONS: Iloperidone demonstrated efficacy in acute exacerbations and long-term maintenance in adults with schizophrenia. Caution may be warranted in elderly patients and patients with cardiac disease, due to orthostasis. Further studies regarding pharmacogenomic testing related to the drug’s efficacy and tolerability are needed to justify its routine use in practice.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system., SDS of cas: 99-14-9, Introducing a new discovery about 99-14-9, Name is Propane-1,2,3-tricarboxylic acid, molecular formula is C6H8O6, belongs to benzisoxazole compound. In a document, author is NAKASA, H.

FORMATION OF REDUCTIVE METABOLITE, 2-SULFAMOYLACETYLPHENOL, FROM ZONISAMIDE IN RAT-LIVER MICROSOMES

Zonisamide (1,2-benzisoxazole-3-methanesulfonamide) was metabolized to its reductive product, 2-sulfamoylacetylphenol, in rat liver microsomes under anaerobic conditions. The rate of NADPH-dependent reaction was much more rapid than that of NADH-dependent reaction. Furthermore, synergistic effect of NADH on NADPH-dependent reaction was not observed. The optimal formation of 2-sulfamoylacetylphenol from zonisamide in the presence of NADPH was observed around pH 7.0. Cimetidine showed an inhibitory effect on the formation of 2-sulfamoylacetylphenol in a dose-dependent manner. The reductive metabolism of zonisamide was almost completely inhibited by carbon monoxide, and was increased by pretreatment of rats with phenobarbital and pregnenolone 16-alpha-carbonitrile but not by pretreatment with ethanol, 3-methylcholanthrene and imidazole. These results suggest that phenobarbital- and pregnenolone 16-alpha-carbonitrile-inducible form(s) of cytochrome P-450 is responsible for the reductive metabolism of zonisamide to 2-sulfamoylacetylphenol in rat liver microsomes.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 99-14-9, in my other articles. SDS of cas: 99-14-9.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Research speed reading in 2021. Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. Application In Synthesis of (R)-2-Hydroxysuccinic acid, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 636-61-3, Name is (R)-2-Hydroxysuccinic acid, molecular formula is C4H6O5. In an article, author is MUTLIB, AE,once mentioned of 636-61-3.

APPLICATION OF HYPHENATED LC/NMR AND LC/MS TECHNIQUES IN RAPID IDENTIFICATION OF IN-VITRO AND IN-VIVO METABOLITES OF ILOPERIDONE

Iloperidone, 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone, is currently undergoing clinical trials as a potential antipsychotic agent. Iloperidone was found to be extensively metabolized to a number of metabolites by rats, dogs, and humans, LC/MS/MS was used to characterize and identify metabolites of iloperidone present in complex biological mixtures obtained from all three species. Identification of some of the unknown metabolites in rat bile was achieved successfully by combination of LC/NMR and LC/MS with a minimum amount of sample cleanup. The utility of coupling a semipreparative HPLC to LC/MS instrument for further characterization of collected metabolites was demonstrated. It was shown that iloperidone was metabolized by O-dealkylation processes to yield 6-fluoro-3-[1-[3-hydroxypropyl)-4-piperidinyl]-1,2-benzisoxazole and 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-2-hydroxyphenyl]ethanone. Oxidative N-dealkylation led to the formation of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole and a secondary metabolite, 3-[(4-acetyl-2-methoxy)phenoxy]propionic acid. Iloperidone was reduced to produce 4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxy-alpha-methylbenzenemethanol as the major metabolite in humans and rats. Hydroxylation of iloperidone produced 1-[4-[3-[4-(6-fluoro-1 ,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-2-hydroxy-5-methoxyphenyl]ethanone and 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1 -piperidinyl]-3-methoxyphenyl]propoxy]-2-hydroxyethanone, the later of which was found to be the principal metabolite in dogs. The identities of all these metabolites were established by comparing the LC/MS retention times and mass spectral data with synthetic standards.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemical Research Letters, May 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. In an article, author is FERRIS, DC, once mentioned the application of 1113-38-8, Name is Ammonium oxalate, molecular formula is C2H8N2O4, molecular weight is 124.1, MDL number is MFCD00013308, category is benzisoxazole. Now introduce a scientific discovery about this category, Application of 1113-38-8.

RATE OF DECARBOXYLATION OF BENZISOXAZOLE-3-CARBOXYLATE IONS AS A PROBE OF SOLVATION IN BIOLOGICAL AND OTHER MEDIA

The influence of solvent donor-acceptor properties and polarity on the rates of decarboxylation of benzisoxazole-3-carboxylate ions is analyzed with the unified solvation model. When the dissolved species is a separated ion pair, solvent polarity decreases the rate. When an equilibrium exists between an ion pair and the dissociated ion pair, solvent polarity and donor strength increase the rate by increasing the extent of dissociation. Hydrogen bonding to the carboxylate functionality causes a significant decrease in rate. When using this probe to measure the solvation properties of solvents, micelles, polymers, or biological assemblies, these different effects must be sorted out to interpret the influence of the medium on the observed rate. The unified solvation model provides a means of sorting out these various contributions.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics