Tag: M.W=300-400

Chemical Research Letters, May 2021. In an article, author is Brinchi, Lucia, once mentioned the application of 843666-40-0, Name is 18-(tert-Butoxy)-18-oxooctadecanoic acid, molecular formula is C22H42O4, molecular weight is 370.5665, MDL number is MFCD09991735, category is benzisoxazole. Now introduce a scientific discovery about this category, Application In Synthesis of 18-(tert-Butoxy)-18-oxooctadecanoic acid.

Accelerated decarboxylation of 6-nitrobenzisoxazole-3-carboxylate in imidazolium-based ionic liquids and surfactant ionic liquids

We report the use of the unimolecular, spontaneous decarboxylation of 6-nitrobenzisoxazole-3-carboxylate, 6-NBIC, as kinetic probe to investigate the properties of aqueous solutions of a series of ILs, 1-alkyl-3-methyl imidazolium derivatives. The ILs are denoted as [C(4)mim][X], where n indicates the number of carbon atoms in 1-alkyl chain. We studied [C(4)mim][Cl] with X = Cl-, Br-, and BF4-, and the surface-active ILs, SAILs, [C(12)mim][Cl], [C(12)mim][Br], and [C(16)mim][Br]. For comparison purposes we also studied nonmicellizing tetrallcylammonium chloride and bromide, denoted as TRAX, where R is alkyl group and X the anion. We observed a steep increase of values of k(obs) after a certain salt concentration for all the systems used. Electrical conductivity of various aqueous systems was measured, in an attempt to rationalize the kinetic effects. Data from conductivity and kinetic are consistent with the idea that after a certain, high, concentration aggregates of ILs form, and data from the kinetics suggest that water is someway squeezed out from these aggregates. As can be deduced from kinetics, properties of the aggregates formed by [C4mim][X] ILs correlate well with bulk water structure affecting properties of the salts, and seem to have no relation to surface effects. (C) 2010 Elsevier Inc. All rights reserved.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. In a document, author is Wang, GJ, introducing its new discovery. Reference of 557-59-5.

Non-cross-linked and cross-linked poly(alkylmethyldiallylammoniumhalides): synthesis and aggregation behavior

Hydrophobically modified polyelectrolytes (polysoaps) are a unique class of water-soluble polymers containing distinct hydrophobic and hydrophilic regions. Above a certain concentration, polysoaps form intramolecular and intermolecular aggregates in aqueous solution. They have attracted much attention not only for their ability to mimic some functions demonstrated by biopolymers but also for their important industrial applications. This review highlights some interesting features of novel non-cross-linked and cross-linked poly(alkylmethyldiallyl-ammonium halides) that have been described in recent years. (C) 1998 John Wiley & Sons, Ltd.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemical Research Letters, May 2021. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. 5117-19-1, Name is 3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol, molecular formula is C16H34O9, Product Details of 5117-19-1, belongs to benzisoxazole compound, is a common compound. In a patnet, author is Abou El-Magd, R. M., once mentioned the new application about 5117-19-1.

The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia

D-Amino acid oxidase (DAO) has been established to be involved in the oxidation of D-serine, an allosteric activator of the N-methyl-D-aspartate-type glutamate receptor in the brain, and to be associated with the onset of schizophrenia. The effect of risperidone, a benzisoxazole derivative, atypical antischizophrenic drug, on the activity of human DAO was tested using an in-vitro oxygraph system and rat C6, stable C6 transformant cells overexpressing mouse DAO (designated as C6/DAO) and pig kidney epithelial cells (LLC-PK1). Risperidone has a hyperbolic mixed- type inhibition, designated as ‘partial uncompetitive inhibition effect’, with K-i value of 41 mu M on human DAO. Risperidone exhibited a protective effect from D-amino acid induced cell death in both C6/DAO and LLC-PK1 cells with 10% increase in viability. These data indicate the involvement of DAO activity in D-serine metabolism and also suggest a new mechanism of action to risperidone as antischizophrenic drug.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemical Research Letters, May 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. In an article, author is Nuhrich, A, once mentioned the application of 557-59-5, Name is Tetracosanoic acid, molecular formula is C24H48O2, molecular weight is 368.6367, MDL number is MFCD00002810, category is benzisoxazole. Now introduce a scientific discovery about this category, Computed Properties of https://www.ambeed.com/products/557-59-5.html.

Synthesis and binding affinities of a series of 1,2-benzisoxazole-3-carboxamides to dopamine and serotonin receptors

A series of 1,2-benzisoxazole-3-carboxamides derived from tertiary cycloalkylamines was synthesized and evaluated for affinity for serotonergic (5-HT3 and 5-HT4) and dopaminergic (D-2) receptors using radioligand binding assays. The majority of compounds displayed a very weak affinity for the studied neurotransmitter receptors. Only amides containing a conformationally rigid system retained a relative 5-HT3 receptor affinity. The presence of a quinuclidine group affected receptor interaction more favorably than the tropane framework.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemical Research Letters, May 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. In an article, author is COHEN, LJ, once mentioned the application of 843666-40-0, Name is 18-(tert-Butoxy)-18-oxooctadecanoic acid, molecular formula is C22H42O4, molecular weight is 370.5665, MDL number is MFCD09991735, category is benzisoxazole. Now introduce a scientific discovery about this category, Electric Literature of 843666-40-0.

RISPERIDONE

Risperidone, a benzisoxazole derivative, is a novel antipsychotic agent that has an extremely strong binding affinity for serotonin 5-HT2 receptors, a strong binding affinity for dopamine D2 receptors, and a high affinity for alpha1- and alpha2-adrenergic receptors and histamine H-1 receptors. Its affinity for serotonin receptors is approximately 200 times greater than that of haloperidol, and its dopamine antagonistic potency is comparable to that of haloperidol. Its major metabolite, 9-hydroxyrisperidone, has similar pharmacologic activity, and thus the parent compound and metabolite form the active antipsychotic moiety Clinical trials demonstrate that risperidone is an effective antipsychotic agent that improves negative as well as positive symptoms of schizophrenia. At recommended dosages, the frequency of extrapyramidal side effects is no greater than that seen with placebo. The drug appears to be an advance in the treatment of psychoses.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards.557-59-5, Name is Tetracosanoic acid, SMILES is CCCCCCCCCCCCCCCCCCCCCCCC(O)=O, in an article , author is Srivastava, S, once mentioned of 557-59-5, COA of Formula: https://www.ambeed.com/products/557-59-5.html.

Photolysis of 3-hydroxy-2,3-dihydro-2,1-benzisoxazole derivatives studied by EPR spectroscopy: Competing N-O and C-O bond scission

Photolysis of 3-hydroxy-2,3-dihydro-2,1-benzisoxazole derivatives gives 2-acetylaniline derivatives as the sole stable products. EPR spectroscopy shows that persistent arylnitroxyl radicals are formed as intermediates and then further photolyzed. A mechanism accounting for these observations is proposed. (C) 1996 Elsevier Science Ltd

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

New Advances in Chemical Research in 2021. Irreversible inhibitors are therefore the equivalent of poisons in heterogeneous catalysis. 5117-19-1, Name is 3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol, molecular formula is C16H34O9, Product Details of 5117-19-1, belongs to benzisoxazole compound, is a common compound. In a patnet, author is Patel, J. M., once mentioned the new application about 5117-19-1.

STUDIES ON THE SYNTHESIS OF FUROBENZISOXAZOLE DERIVATIVES

The present investigation reports the synthesis of new furobenzisoxazole derivatives. Posner reaction of hydroxyfurocoumarin has been studied, wherein the two reaction products are identified as 5-methylfuro[2′,3′: 4,5] benzo[ 1,2-d] isoxazol-3-yl) acetic acid and 1-(6- hydroxy- 3- methylbenzofuran5- yl) ethanone oxime, depending on the conditions used. 1,3,4- Oxadiazole, 2- mercapto- 1,3,4- oxadiazole and thiazolidinone derivatives of furobenzisoxazole were synthesized from hydrazide.

Product Details of 5117-19-1, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 5117-19-1 is helpful to your research.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Research speed reading in 2021. Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter. Category: Benzisoxazole, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. 5117-19-1, Name is 3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol, molecular formula is C16H34O9. In an article, author is SUTO, MJ,once mentioned of 5117-19-1.

SYNTHESIS AND EVALUATION OF A SERIES OF 3,5-DISUBSTITUTED BENZISOXAZOLE-4,7-DIONES – POTENT RADIOSENSITIZERS INVITRO

A series of 3,5-disubstituted-2,1-benzisoxazole-4,7-diones was synthesized and evaluated as radiosensitizers both in vitro and in vivo. These compounds were designed as non-nitro electron-affinic agents in an effort to alleviate some of the toxicities seen with the 2-nitroimidazole radiosensitizers evaluated in the clinic. Several compounds in this series were potent radiosensitizers in vitro, with sensitizer enhancement ratios of 2.0-2.3 at concentrations < 0.5 mM. Compounds with potent in vitro activity were also evaluated in vivo. However, none of these compounds showed radiosensitizing activity in vivo. The reduction potentials of these compounds were determined by cyclic voltammetry and compared to other electron-affinic radiosensitizers. In general, the reduction potentials of this series of compounds was slightly more positive than the 2-nitroimidazoles, but they fell within the range postulated as acceptable to yield in vivo activity. The results suggest that factors other than reduction potential may be responsible for the lack of in vivo radiosensitizing activity observed for this class of radiosensitizers. Interested yet? This just the tip of the iceberg, You can reading other blog about 5117-19-1, Category: Benzisoxazole.

Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system., Application of 557-59-5, Introducing a new discovery about 557-59-5, Name is Tetracosanoic acid, molecular formula is C24H48O2, belongs to benzisoxazole compound. In a document, author is Prasad, S. B. Benaka.

Synthesis of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole derivatives as antiproliferative agents: A structure-activity relationship study

A series of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole derivatives 5(a-m) were synthesized with different substituted aromatic/heterocyclic acid chlorides (R-CO-Cl) and characterized by H-1 NMR, LC/MS, FTIR and elemental analyses. All the compounds synthesised were evaluated for their antiproliferative activity by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The antiproliferative effects of the synthesised compounds were tested against viable human skin fibroblast cells and carcinoma cells namely HeLa cells, HT-29 cells, MCF-7 cells, HepG-2 cells by adopting positive and negative control. The importance of the aromatic and heterocyclic moiety was confirmed. From the SAR studies, it reveals that, the substitution at N-terminal of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole by the heterocyclic ring plays a dominant role and was responsible for the antiproliferative activity. Among the synthesized compounds 5a, 5d and 5k have showed potent antiproliferative activity on all the carcinoma cells tested.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics

Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are found throughout, and are directly involved in the manufacturing process of chemical products and materials. Recommanded Product: 18-(tert-Butoxy)-18-oxooctadecanoic acid.

Theoretical Insights into Ester-Directed Reactions between Propiolates with 1,2-Benzisoxazoles by Au(I) Catalyst: [4+2]-Annulation versus Michael-Type Products

Au(I)-catalyzed selective reactions of Et- and Bu-t-substituted propiolates (1a and 1a’) with 1,2-benzisoxazole(2a) provide a new strategy for purposefully access to desired bioactive heterocycles. Using DFT calculations, we have systematically investigated the detailed mechanisms and origins of the ester-controlled chemoselectivity. The calculated results indicated that both reactions are initiated by LAu+ pi-coordination, N nucleophilic attack, and NTf2–assisted stepwise H-shift, generating a nitrilium species identified as a common and requisite intermediate, which is significantly different from the experimentally proposed 6-alkoxy-1,3-oxazin-1-ium intermediate. Starting from the nitrilium intermediate, the newly established nucleophilic cyclization, alkene release, and NTf2–assisted stepwise protodeauration provides [4 + 2]-annulation product P-1, while the nitrilum dissociation, O nucleophilic attack, and NTf2–assisted stepwise protodeauration generates Michael-type product P-2. Further explorations showed that Bu-t-controlled chemoselectivity of P-1 over P-2 can be attributed to the energy favorable aromaticity of selective-determining nucleophilic cyclization TS. With substitution of Bu-t by Et group, the reversal of chemoselectivity to P-2 formation might be closely related to the presence of extremely unstable Et cation in ethylene release TS leading to P-1.

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Reference:
Benzisoxazole – Wikipedia,
,Benzisoxazole – an overview | ScienceDirect Topics