Computed Properties of C6H10O3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl tetrahydrofuran-2-carboxylate, is researched, Molecular C6H10O3, CAS is 37443-42-8, about Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists. Author is Doherty, George A.; Yang, Ginger X.; Borges, Edite; Chang, Linda L.; MacCoss, Malcolm; Tong, Sharon; Kidambi, Usha; Egger, Linda A.; McCauley, Ermenegilda; Van Riper, Gail; Mumford, Richard A.; Schmidt, John A.; Hagmann, William K..
A series of substituted tetrahydrofuroyl-1-phenylalanine derivatives was prepared and evaluated as VLA-4 antagonists. Substitution of the α carbon of the THF with aryl groups increased the specificity for VLA-4 vs. α4β7 while amide substitution increased the potency of the series without increasing the specificity. Substitution of the β carbon of the THF with keto or amino groups slightly improved the specificity for VLA-4 vs. α4β7 but with a significant loss in binding affinity for VLA-4.
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